Modulation of 5-fluorouracil in mice using uridine diphosphoglucose

Clinical Cancer Research

Volumn 3, Issue 2, 1997, Pages 309-315

  Codacci Pisanelli, Giovanni ^a   Kralovanszky, Judit ^b   Van der Wilt, Ciasina L ^d   Noordhuis, Paul ^d   Colofiore, Joseph R ^c   Martin, Daniel S ^c   Franchi, Fabrizio ^a   Peters, Godefridus J ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; URIDINE DIPHOSPHATE GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; COLON CARCINOMA; CONTROLLED STUDY; DRUG TOXICITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLONIC NEOPLASMS; DIGESTIVE SYSTEM; DRUG INTERACTIONS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLUOROURACIL; LEUKOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTECTIVE AGENTS; URIDINE DIPHOSPHATE GLUCOSE;

EID: 0031029307     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Pinedo, H. M., and Peters, G. J. Fluorouracil: biochemistry and pharmacology. J. Clin. Oncol., 6: 1653-1664, 1988.
2. Peters, G. J., and Van Groeningen, C. J. Clinical relevance of biochemical modulation of 5-fluorouracil. Ann. Oncol., 2: 469-480, 1991.
3. Nord, L. D., Stolfi, R. L., and Martin, D. S. Biochemical modulation of 5-fluorouracil with leucovorin or delayed undine rescue. Biochem. Pharmacol., 43: 2543-2549, 1992.
4. Hryniuk, W. M. The importance of dose-intensity in the outcome of chemotherapy. In: V. T. De Vita, S. Hellman, and S. A. Rosenberg (eds.), Important Advances in Oncology, pp. 121-141, Philadelphia: J. B. Lippincott Co., 1988.
5. Ardalan, B., Singh, G., and Silberman, H. A randomized Phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal carcinoma. J. Clin. Oncol., 6: 1053-1058, 1988.
6. Arbuck, S. G. Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. Cancer (Phila.), 63: 1036-1044, 1989.
7. Brohee, D. 5-fluorouracil and folinic acid in the treatment of advanced colorectal cancer: an updated meta-analysis. Med. Sci. Res., 22: 383-384, 1994.
8. Van Groeningen, C. J., Peters, G. J., and Pinedo, H. M. Modulation of fluorouracil toxicity with uridine. Semin. Oncol., 19: 148-154, 1992.
9. Martin, D. S., Stolfi, R. L., Sawyer, R. C., Spiegelman, S., and Young, C. W. High-dose 5-fluorouracil with delayed uridine "rescue" in mice. Cancer Res., 42: 3964-3970, 1982.
10. Klubes, P., and Cerna, I. Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil. Cancer Res., 43: 3182-3186, 1983.
11. Peters, G. J., Van Dijk, J., Laurensse, E., Van Groeningen, C. J., Lankelma, J., Leyva, A., Nadal, J. C., and Pinedo, H. M. In vitro biochemical and in vivo biological studies of the uridine rescue of 5-fluorouracil. Br. J. Cancer, 57: 259-265, 1988.
12. Nadal, J. C., Van Groeningen, C. J., Pinedo, H. M., and Peters, G. J. Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma. Invest. New Drugs, 7: 163-172, 1989.
13. Klubes, P., and Leyland-Jones, B. Enhancement of the antitumor activity of 5-fluorouracil by uridine rescue. Pharmacol. Ther., 41: 289-303, 1989.
14. Van Groeningen, C. J., Leyva, A., Kraal, I., Peters, G. J., and Pinedo, H. M. Clinical and pharmacokinetic study of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity. Cancer Treat. Rep., 70: 745-750, 1986.
15. Van Groeningen, C. J., Peters, G. J., Leyva, A., Laurensse, E., and Pinedo, H. M. Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine. J. Natl. Cancer Inst., 81: 157-162, 1989.
16. Tognella, S. Uridine rescue of the FUra toxicity. The possible role of uridine diphosphoglucose (UDPG). Anticancer Res., 12: 1923-1924, 1992.
17. Conti, J. A., Kemeny, N., Kelly, J., Gonzalez, G., Bertino, J., and Martin, D. S. Triacetyluridine (TAU) as rescue from 5-fluorouracil (FU) toxicity allows increased FU dose intensity when given with N-phosphonacetyl-L-aspartate (PALA) and methotrexate in advanced colorectal carcinoma. Proc. Am. Soc. Clin. Oncol., 14: 485, 1995.
18. Colofiore, J. R., Sawyer, R. C., Balis, M. E., and Martin, D. S. Effect of uridine diphosphoglucose on levels of 5-phosphoribosyl pyrophosphate and uridine triphosphate in murine tissues. Pharm. Res., 6: 863-866, 1989.
19. Colofiore, J. R., Stolfi, R. L., and Martin, D. S. Uridine diphosphoglucose (UDPG) as an alternative to free uridine (UR) for the rescue from 5-fluorouracil (FU)-associated toxicity. Proc. Am. Assoc. Cancer Res., 32: 340, 1991.
20. Bagrij, T., Kralovanszky, J., Gyergyay, F., Kiss, E., and Peters, G. J. Influence of uridine treatment in mice on the protection of gastrointestinal toxicity caused by 5-fluorouracil. Anticancer Res., 13: 789-794, 1993.
21. Peters, G. J., Van Groeningen, C. J., Laurensse, E., Lankelma, J., Leyva, A., and Pinedo, H. M. Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. Cancer Chemother. Pharmacol., 20: 101-108, 1987.
22. Hartman, H. R., and Bollag, W. Modulation of the effect of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine. Med. Oncol. Tumor Pharmacother., 3: 111-118, 1986.
23. Au, J. L. S., Wientjes, M. G., and Bramer, S. L. Effect of uridine coadministration on 5′-deoxy-5-fluorouridine disposition in rats. Cancer Chemother. Pharmacol., 22: 5-10, 1988.
24. Klubes, P., Cerna, I., and Meldon, M. A. Uridine rescue from the lethal toxicity of 5-fluorouracil in mice. Cancer Chemother. Pharmacol., 8: 17-21, 1982.
25. Christman, K., Schwartz, G., Saltz, L., Dougherty, J., Casper, E., Yao, T., Toomasi, F., Friedrich, C., Martin, D., Bertino, J., and Kelsen, D. Uridine (Urd) allows dose-intensification of FAMTX (5-fluorouracil (FU), Adriamycin (A), Methotrexate (Mtx)). Proc. Am. Soc. Clin. Oncol., 12: 200, 1993.
26. Peters, G. J., Laurensse, E., Leyva, A., and Pinedo, H. M. Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity. Eur. J. Cancer & Clin. Oncol., 12: 1869-1881, 1987.
27. Van Groeningen, C. J., Peters, G. J., and Pinedo, H. M. Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine. Ann. Oncol., 4: 317-320, 1993.
28. Darnowski, J. W., and Handschumacher, R. E. Tissue uridine pools: evidence in vivo of a concentrative mechanism for uridine uptake. Cancer Res., 46: 3490-3494, 1986.
29. Seiter, K., Kemeny, N., Martin, D., Schneider, A., Williams, L., Colofiore, J., and Sawyer, R. Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin. Cancer (Phila.), 71: 1875-1881, 1993.
30. Cradock, J. C., Vishnuvajjala, B. R., Chin, T. F., Hochstein, H. D., and Ackerman, S. K. Uridine-induced hyperthermia in the rabbit. J. Pharm. Pharmacol., 38: 226-229, 1986.
31. Peters, G. J., Van Groeningen, C. J., Laurensse, E., Kraal, I., Leyva, A., Lankelma, J., and Pinedo, H. M. Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data. Pharm. Res., 4: 113-119, 1987.
32. Beck, A., Etienne, M. C., Cheradame, S., Fischel, J. L., Formento, P., Guillot, T., and Milano, G. Wide range for optimal concentration of folinic acid in fluorouracil modulation: experimental data on human tumour cell lines. Eur. J. Cancer, 30A: 1522-1526, 1994.
33. Peters, G. J., Van der Wilt, C. L., Smid, K., Ruiz van Haperen, V., Veerman, G., Laurensse, E., and Pinedo, H. M. Pyrimidine metabolism in murine colon cancer models: relevance for chemotherapy with antimetabolites. Biochem. Pharmacol. (Life Sci. Adv.), 9: 365-373, 1990.
34. Grem, J. L., Shoemaker, D. D., Petrelli, N. J., and Douglass, H. O. Severe life-threatening toxicities observed in study using leucovorin with 5-fluorouracil. J. Clin. Oncol., 5: 1704, 1987.