A comparison of one- and two-sided tests for judging significant differences in quantitative data obtained in toxicological bioassay of laboratory animals

Journal of Occupational Health

Volumn 39, Issue 1, 1997, Pages 29-35

  Kobayashi, Katsumi ^a  

^a Biosafety Research Center   (Japan)

Author keywords

test; Dunnett's test; One or two sided test; Statistical analysis; Toxicological bioassay

Indexed keywords

ARTICLE; BIOASSAY; CARCINOGENICITY; CHRONIC TOXICITY; EXPERIMENTAL ANIMAL; LONG TERM EXPOSURE; NONHUMAN; QUANTITATIVE ASSAY; STATISTICAL ANALYSIS; TOXICOLOGY;

EID: 0031029126     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.39.29     Document Type: Article

References (27)

1. Japanese Ministry of Agriculture, Forestry and Fisheries. Guideline on Toxicology Study Data for Application of Agricultural Chemical Registration, 59 NohSan No. 4200. Tokyo: 1985 (in Japanese).
2. Japanese Ministry of Health and Welfare. Guidelines for Toxicity Studies of Drugs, Notification No. 1-24 of the Pharmaceutical Affairs Bureau. Tokyo: 1989 (in Japanese).
3. Gad S, Weil CS. Student's /-test, Chochran Mest. In : Wallace HA. ed. Statistics for toxicologists, principles and methods of toxicology. New York: Raven Press, 1982:286-288.
4. Yoshimura I, Ohashi S. Statistical analysis for toxicology data. Tokyo: Chijin shokan, 1992: 92, 96-98, 110 (in Japanese).
5. Kansai Applied Statistical Association. Statistical analysis for toxicity studies. Toxicology-forum 1987; 10: 543 (in Japanese).
6. Dunnett CW. A multiple comparison procedure for comparing several treatment with a control. J Am Stat Assoc 1955; 50: 1096-1121.
7. Imamizo Y, Koda S, Sano M, et al. Mest, Welch's test, Dunnett's test, f-tables, Dunnett's tables In: Yoshimura I, ed. Statistical analyses for toxicological data. Tokyo: Scientist, 1987: 22, 30-37, 61-62, 248, 263-264 (in Japanese).
8. Drewitt PN, Butterworth CD, Springall CD, Moorhouse SR. Plasma levels of aluminum after tea ingestion in healthy volunteers. Fd Chem Toxic 1993; 31: 19-23.
9. Shertzer HG, Sainsbury M. Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats. Fd Chem Toxic 1991;29:391-400.
10. Williams DA. A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 1971; 27: 103117.
11. Williams DA. The comparison of several dose levels with a zero dose control. Biometrics 1972; 28: 519531.
12. National Institutes of Health. Toxicology and carcinogenesis studies of quercetin in F344/N rats. National Toxicology Program Technical Report Series, 1992; No. 409: 20.
13. National Institutes of Health. Toxicology and carcinogenesis studies of polysorbate 80 in F344/N rats and B6C3F, mice. National Toxicology Program Technical Report Series, 1992; No. 415: 19-20.
14. Dünn OJ. Multiple comparisons using rank sums. Technometrics 1964; 6: 106-107.
15. Shirley E. A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 1977; 33: 386-389.
16. National Institutes of Health. Toxicology and carcinogenesis studies of hexachloroethane in F344/N rats. National Toxicology Program Technical Report Series. 1989; No. 361: 25-26.
17. Dunnett CW. Parewise multiple comparisons in the unequal variance case. J Am Stat Assoc 1980; 75: 796-800.
18. National Institutes of Health. Toxicology and carcinogenesis studies of two pentachlorophenol technicalgrade mixtures in B6C3F, mice. National Toxicology Program Technical Report Series. 1989; No. 349: 47.
19. National Institutes of Health. Toxicology and carcinogenesis studies of 2-chloroacetophenone in F344/N rats and B6C3F, mice. National Toxicology Program Technical Report Series. 1990; No. 379: 2324.
20. National Institutes of Health. Toxicology and carci-nogenesis studies of 2-probenecid in F344/N rats and B6C3F] mice. National Toxicology Program Technical Report Series. 1991 ; No. 395: 20.
21. Furukawa S, Nishida I, Kikumori M, et al. Twentysix-week intravenous toxicity study of montirelin hydrate (NS-3) in rats followed by 9-week recovery test. J Toxicol Sei 1995; 20 Sup. II: 191-213.
22. Leibbrandt EI, Wolfgang GHI. Differential toxicity of cisplatin, carboplantin, and Cl-973 correlates with cellular platinum levels in rats renal cortical slices. Toxicol Appl Pharmacol 1995; 132:245-252.
23. Vaittinen SL, Komulainen H, Kosma VM, et al. Subchronic toxicity of 2-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in wistar rats. Fd Chem Toxic 1995; 33: 1027-1037.
24. Gad S, Weil CS. Statistics and experimental design for toxicologists. New Jersey: The Telford Press, 1986: 71-72.
25. Sakuma A. Statistical methods in pharmacometrics I. Tokyo: Tokyodaigaku Shupankai, 1977: 56 (in Japanese).
26. Nakamura G. Practice, statistical analyses. Tokyo: Kaimei-Sha, 1986: 106-107 (in Japanese).
27. Ishii S. Bio-statistical analyses guidance. Tokyo: Baihukan, 1975: 68 (in Japanese).