Antihyperglycaemic effect of saccharin in diabetic ob/ob mice

British Journal of Pharmacology

Volumn 120, Issue 1, 1997, Pages 74-78

  Bailey, Clifford J ^a   Day, Caroline ^a   Knapper, Jacqueline M E ^a   Turner, Susan L ^a   Flatt, Peter R ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Antihyperglycaemic; Glucose tolerance; Glycogen; Insulin; Obese diabetic ob ob mice; Saccharin

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN; SACCHARIN SODIUM;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPHAGIA; INSULIN RESISTANCE; INSULIN RESPONSE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIVER GLYCOGEN; MICE; MICE, OBESE; OBESITY; SACCHARIN;

EID: 0031029059     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700871     Document Type: Article

References (25)

1. AMERICAN DIABETES ASSOCIATION. (1993). Nutritional recommendations and principles for individuals with diabetes mellitus. Position statement. Diabet. Care, 16 suppl 2, 23-29.
2. BAILEY, C.J. & AHMED-SOROUR, H. (1980). Role of ovarian hormones in the long-term control of glucose homeostasis. Effects on insulin secretion. Diabelologia, 19, 475-481.
3. BAILEY, C.J. & FLATT, P.R. (1991). Animal models of non-insulin-dependent diabetes mellitus. In Textbook of Diabetes. ed. Pickup, J.C. & Williams, G., pp. 228-239. Oxford: Blackwell.
4. BAILEY, C.J., FLATT, P.R. & ATKINS, T.W. (1982). Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice. Int. J. Obesity, 6, 11-21.
5. BAILEY, C.J., PAGE, T., DAY, C. & THORNBURN, C.C. (1992). Acute effect of benfluorex on glucose metabolism. Biochem. Pharmacol., 44, 379-382.
6. BATCHELOR, B.R., STERN, J.S., JOHNSON, P.R. & MAHLER, R. (1975). Effects of streptozotocin on glucose metabolism, insulin response, and adiposity in ob/ob mice. Metabolism, 24, 77-91.
7. BRICHARD, S.M., BAILEY, C.J. & HENQUIN, J-C. (1990). Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate. Diabetes, 39, 1326-1332.
8. DEUTSCH, R. (1974). Conditioned hypoglycemia: a mechanism for saccharin-induced sensitivity to insulin in the rat. J. Comp. Physiol. Psychol., 86, 350-358.
9. FLATT, P.R. & BAILEY, C.J. (1981a). Abnormal plasma glucose and insulin responses in heterozygous lean (ob/ob) mice. Diabetologia, 20, 573-577.
10. FLATT, P.R. & BAILEY, C.J. (1981b). Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycaemic (ob/ob) mice. Hormone Metab. Res., 13, 556-560.
11. FLATT, P.R. & BAILEY, C.J. (1982). Role of dietary factors in the hyperinsulinaemia of genetically obese hyperglycemic (ob/ob) mice. J. Nutrition, 112, 2212-2216.
12. FLATT, P.R. & BAILEY, C.J. (1984). Dietary components and plasma insulin responses to fasting and refeeding in genetically obese hyperglycaemic (ob/ob) mice. Br. J. Nutrition, 51, 403-413.
13. GOLDFINE, I.D., RYAN, W.G. & SCHWARTZ, T.B. (1969). The effect of glucola, diet cola, and water ingestion on blood glucose and plasma insulin. Proc. Soc. Exp. Biol. Med., 131, 329-330.
14. HORWITZ, D.L., McLANE, M. & KOBE, P. (1988). Response to a single dose of aspartame or saccharin by NIDDM patients. Diabet. Care, 11, 230-234.
15. IONESCU, E., ROHNER-JEANRENAUD, F., PROIETTO, J., RIVEST. R.W. & JEANRENAUD, B. (1988). Taste-induced changes in plasma insulin and glucose turnover in lean and genetically obese rats. Diabetes, 37, 773-779.
16. KALKHOFF. R.K. & LEVIN, M.E. (1978). The saccharin controversy. Diabet. Care, 1, 211-222.
17. KIMMICH, G.A., RANDLES, J. & ANDERSON, R.L. (1988). Inhibition of the serosal sugar carrier in isolated intestinal epithelial cells by saccharin. Food Chem. Toxicol., 26, 927-934.
18. MILLER, S.A. & FRATTALLI, V.P. (1989). Saccharin. Diabet. Care, 12, 75-80.
19. MINISTRY OF AGRICULTURE, FISHERIES AND FOOD (1990). Intakes of intense and bulk sweeteners in the UK, 1987-1988. In Food Surveillance Paper No. 29. London: Her Majesty's Stationery Office.
20. MITCHELL, M.L. & PEARSON, R.L. (1991). Saccharin. Food Sci. Technol., 48, 127-156.
21. NUTRITION SUBCOMMITTEE, BRITISH DIABETIC ASSOCIATION. (1992). Role of diabetic foods in the diabetic diet. Diabet. Med., 9, 300-306.
22. PROELS, H., HASLBECK, M. & MEHNERT, H. (1973). Action of high doses of saccharin on metabolism in diabetics. Deutsche Med. Wochenschr., 98, 1901-1904.
23. PURDOM, M.E., HYDER, K. & PYBAS, M.D. (1973). Effects of saccharin on rats fed chemically defined diets. Growth and blood studies. J. Am. Diet. Assoc., 63, 635-638.
24. STEVENS, J.F. (1971). Determination of glucose by an automatic analyser. Clin. Chim. Acta, 32, 199-201.
25. VALENSTEIN, E.S. & WEBER, M.L. (1965). Potentiation of insulin coma by saccharin. J. Comp. Physiol. Psychol., 60, 443-446.