Does lethal myocardial reperfusion injury exist?

Journal of Thrombosis and Thrombolysis

Volumn 4, Issue 1, 1997, Pages 91-93

  Flaherty, John T ^a,b   Zweier, Jay L ^b,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; FIBRINOLYTIC AGENT; GLUTATHIONE PEROXIDASE; OXYGEN RADICAL; SCAVENGER; SUPEROXIDE DISMUTASE;

ACUTE HEART INFARCTION; ARTICLE; CLINICAL TRIAL; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE TACHYCARDIA; HUMAN; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 0031028627     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017523123795     Document Type: Article

References (12)

1. Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 1987;84:1404-1407.
2. Grill HP, Zweier JL, Kuppusamy P, Weisfeldt ML, Flaherty JT. Direct measurement of myocardial free radical gen-eration in an in-vivo model: Effects of post-ischemic reperfusion and treatment with human recombinant superoxide dismutase. J Am Coll Cardiol 1992;20:1604-1611.
3. Ambrosio G, Weisfeldt ML, Jacobus WE, Flaherty JT. Evidence of a reversible oxygen radical mediated component of reperfusion injury: Reduction by recombinant human superoxide dismutase administered at the time of reflow. Circulation 1987;75:282-291.
4. Zweier JL, Rayburn BK, Flaherty JT, Weisfeldt ML. Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium. J Clin Invest 1987;80:1728-1734.
5. Ambrosio G, Becker LC, Hutchins GM, Weisman HF, Weisfeldt ML. Reduction in experimental infarct size by recombinant human superoxide dismutase: Insights into the pathophysiology of reperfusion injury. Circulation 1986;74:1424-1433.
6. Xia Y, Zweier JL. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J Biol Chem 1995;270:18797-18803.
7. Flaherty JT, Pitt B, Gruber JW, et al. Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 1994;89:1982-1991.
8. Murohara Y, Yui Y, Hattori R, Kawai C. Effects of superoxide dismutase on reperfusion arrhythmias and left ventricular function in patients undergoing thrombolysis for anterior wall acute myocardial infarction. Am J Cardiol 1991;67:765-767.
9. Omar BA, McCord JM. Interstitial equilibration of superoxide dismutase correlates with its protective effect in the isolated rabbit heart. J Mol Cell Cardiol 1991;23:149-159.
10. Chi L, Tamura Y, Hoff P, Macha M, Gallagher KP, Schork MA, Lucchesi BR. Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: A demonstration of myocardial salvage Circ Res 1989;64:665-675.
11. Omar BA, Gad NM, Jordan MC, et al. Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart. Free Radic Biol Med 1990;9:465-471.
12. Nejima J, Knight DR, Fallon JT, et al. Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs. Circulation 1989;79:143-153.