The nfkb1 promoter is controlled by proteins of the Ets family

Molecular Biology of the Cell

Volumn 8, Issue 2, 1997, Pages 313-323

  Lambert, Paul F ^a   Ludford Menting, Mandy J ^a   Deacon, Nicholas J ^a   Kola, Ismail ^b   Doherty, Richard R ^b  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; AUTOREGULATION; DNA TRANSFECTION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0031028613     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.2.313     Document Type: Article

References (51)

1. Ascione, R., Thompson, D.M., Thomas, R.S., Panayiotakis, A., Ramsay, R., Tymms, M., Kola, I., and Seth, A. (1992). Influence of nucleotides flanking the GGAA core sequence on Ets-1 and Ets-2 DNA binding activity and the mechanism of Ets-1 autoregulation. Int. J. Oncol. 1, 631-637.
2. Baeuerle, P.A., and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
3. Beg, A.A., Finco, T.S., Nantermet, P.V., and Baldwin, A.S., Jr. (1993). Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 13, 3301-3310.
4. Bhat, N.K., Komschlies, K.L., Fujiwara, S., Fisher, R.J., Mathieson, B.J., Gregorio, T.A., Young, H.A., Kasik, J.W., Ozato, K., and Papas, T.S. (1989). Expression of ets genes in mouse thymocyte subsets and T cells. J. Immunol. 142, 672-678.
5. Bories, J.-C., Willerford, D.M., Grevin, D., Davidson, L., Camus, A., Martin, P., Stéhelin, D., and Alt, F.W. (1995). Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 377, 635-638.
6. Churchill, M.J. (1993). Transcriptional regulation of HIV-1 gene expression. Ph.D. Thesis: University of Melbourne, Melbourne, Australia.
7. Clark, N.M., Hannibal, M.C., and Markovitz, D.M. (1995). The peri-κB site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells. J. Virol. 69, 4854-4862.
8. Cogswell, P.C., Scheinman, R.I., and Baldwin, A.S., Jr. (1993). Promoter of the human NF-κB p50/p105 gene. Regulation by NF-κB subunits and by c-REL. J. Immunol. 150, 2794-2804.
9. Dobrzanski, P., Ryseck, R.P., and Bravo, R. (1994). Differential interactions of Rel-NF-κB complexes with IκBα determine pools of constitutive and inducible NF-κB activity. EMBO J. 13, 4608-4616.
10. Duckett, C.S., Perkins, N.D., Kowalik, T.F., Schmid, R.M., Huang, E.S., Baldwin, A.S., Jr., and Nabel, G.J. (1993). Dimerization of NF-κB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an IκB-α (MAD-3). Mol. Cell. Biol. 13 1315-1322.
11. Galson, D.L., Hensold, J.O., Bishop, T.R., Schalling, M., D'Andrea, A.D., Jones, C., Auron, P.E., and Housman, D.E. (1993). Mouse β-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol. Cell. Biol. 13, 2929-2941.
12. Gegonne, A., Bosselut, R., Bailly, R.A., and Ghysdael, J. (1993). Synergistic activation of the HTLV-I LTR Ets-responsive region by transcription factors Ets1 and Sp1. EMBO J. 12, 1169-1178.
13. Gottschalk, L.R., Giannola, D.M., and Emerson, S.G. (1993). Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites. J. Exp. Med. 178, 1681-1692.
14. Griffin, G.E., Leung, K., Folks, T.M., Kunkel, S., and Nabel, G.J. (1989). Activation of HIV gene expression during monocyte differentiation by induction of NF-κB. Nature 339, 70-73.
15. Grumont, R.J., Richardson, I.E., Gaff, C., and Gerondakis, S. (1993). rel/NF-κB nuclear complexes that bind κB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells. Cell Growth Differ. 4, 731-743.
16. Henkel, T., Machleidt, T., Alkalay, I., Kranke, M., Ben Neriah, Y., and Baeuerle, P.A. (1993). Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365, 182-185.
17. + T lymphocytes. Science 256, 1452-1456.
18. Klemsz, M.J., McKercher, S.R., Celada, A., Van Beveren, C., and Maki, R.A. (1990). The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61, 113-124.
19. Kola, I., Brookes, S., Green, A.R., Garber, R., Tymms, M., Papas, T.S., and Seth, A. (1993). The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation. Proc. Natl. Acad. Sci. USA 90, 7588-7592.
20. Le Bail, O., Schmidt Ullrich, R., and Israel, A. (1993). Promoter analysis of the gene encoding the IκB-α/MAD3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO J. 12, 5043-5049.
21. Leiden, J.M., Wang, C.Y., Petryniak, B., Markovitz, D.M., Nabel, G.J., and Thompson, C.B. (1992). A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. J. Virol. 66, 5890-5897.
22. Lernbecher, T., Kistler, B., and Wirth, T. (1994). Two distinct mechanisms contribute to the constitutive activation of ReIB in lymphoid cells. EMBO J. 13, 4060-4069.
23. Lewin, S.R., Lambert, P.F., Deacon, N.J., Mills, J., and Crowe, S.M. Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation. J. Virol. (in press).
24. Liou, H.C., and Baltimore, D. (1993). Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol. 5, 477-487.
25. Liptay, S., Schmid, R.M., Nabel, E.G., and Nabel, G.J. (1994). Transcriptional regulation of NF-κB2: evidence for κB-mediated positive and negative autoregulation. Mol. Cell. Biol. 14, 7695-7703.
26. Lombardi, L., Ciana, P., Cappellini, C., Trecca, D., Guerrini, L., Migliazza, A., Maiolo, A.T., and Neri, A. (1995). Structural and functional characterization of the promoter regions of the NFKB2 gene. Nucleic Acids Res. 23, 2328-2336.
27. Luckow, B., and Schutz, G. (1987). CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15, 5490.
28. Macleod, K., Leprince, D., and Stéhlein, D. (1992). The ets gene family. Trends Biochem. Sci. 27, 251-256.
29. Markovitz, D.M., Smith, M.J., Hilfinger, J., Hannibal, M.C., Petryniak, B., and Nabel, G.J. (1992). Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and κB regulatory elements. J. Virol. 66, 5479-5484.
30. McElhinny, J.A., MacMorran, W.S., Bren, G.D., Ten, R.M., Israel, A., and Paya C.V. (1995). Regulation of IκBα and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus. J. Virol. 69, 1500-1509.
31. Mercurio, F., Didonato, J.A., Rosette, C., and Karin M. (1993). p015 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction. Genes Dev. 7, 705-718.
32. Miyamoto, S., Chiao, P.J., and Verma, I.M. (1994a). Enhanced IκBα degradation is responsible for constitutive NF-αB activity in mature murine B-cell lines. Mol. Cell. Biol. 14, 3276-3282.
33. Miyamoto, S., Maki, M., Schmitt, M.J., Hatanaka, M., and Verma I.M (1994b). Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB. Proc. Natl. Acad. Sci. USA 92, 12740-12744.
34. Mizushima, S., and Nagata, S. (1990). pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18, 5322.
35. Muthuswamy, N., Barton, K., and Leiden, J.M. (1995). Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 377, 639-642.
36. Naumann, M., Nieters, A., Hatada, E.N., and Scheidereit, C. (1993a). NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors. Oncogene 8, 2275-2281.
37. Naumann, M., Wulczyn, E.G., and Scheidereit, C. (1993b). The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J. 12, 213-222.
38. Paya, C.V., Ten, R.M., Bessia, C., Alcami, J., Hay, R.T., and Virehzier, J.L. (1992). NF-κB-dependent induction of the NF-κB p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells. Proc. Natl. Acad. Sci. USA 89, 7826-7830.
39. Rice, N.R., MacKichan, M.L., and Israel, A. (1992). The precursor of NF-κB p50 has IκB-like functions. Cell 71, 245-253.
40. Riviere, Y., Blank, V., Kourilsky, P., and Israel, A. (1991). Processing of the precursor of NF-κB by the HIV-1 protease during acute infection. Nature 350, 525-626.
41. Rosen, C.A., Park, A.S., and Peterlin, B.M. (1987). Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression. Proc. Natl. Acad. Sci. USA 84, 4919-4923.
42. Roulston, A., Lin, R., Beauparlant, P., Wainberg, M.A., and Hiscott J. (1995) Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-κB/Rel transcription factors. Microbiol. Rev. 59, 481-505.
43. Salmon, P., Giovane, A., Wasylyk, B., and Klatzmann, D. (1993). Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc. Natl. Acad. Sci. USA 90, 7739-7743.
44. Sen, R., and Baltimore, D. (1986). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46, 705-716.
45. Sun, S.C., Ganchi, P.A., Beraud, C., Ballard, D.W., and Greene W.C. (1994) Autoregulation of the NF-κB transactivator Re1A (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA 91, 1346-1350.
46. Ten, R.M., Paya, C.V., Israel, N., Le Bail, O., Mattei, M.G., Virelizier, J.L., Kourilsky P., and Israel, A. (1992). The characterization of the promoter of the gene encoding the P50 subunit of NF-κB indicates that it participates in its own regulation. EMBO J. 11, 195-203.
47. Thomas, R.S., Tymms, M.J., Seth, A., Shannon, M.F., and Kola I. (1995) ETS1 transactivates the human GM-CSF promoter m Jurkat T cells stimulated with PMA and ionomycin. Oncogene 11, 2135-2143.
48. Tymms, M.J., and Kola, I. (1994). Regulation of gene expression by transcription factors Ets-1 and Ets-2. Mol. Reprod. Dev. 39, 208-214.
49. Wang, Y., Larsen, A.S., and Peterlin, B.M. (1987). A tissue-specific transcriptional enhancer is found in the body of the HLA-DRα gene. J. Exp. Med. 166, 625-636.
50. Wasylyk, B., Hahn, S.L., and Giovane, A. (1993). The Ets family of transcription factors. Eur. J. Biochem. 211, 7-18.
51. Weih, F., Carrasco, D., and Bravo, R. (1994). Constitutive and inducible Rel/NF-αB activities in mouse thymus and spleen. Oncogene 9, 3289-3297.