Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila

Proceedings of the Society for Experimental Biology and Medicine

Volumn 214, Issue 1, 1997, Pages 69-75

  Smith, Margaret S ^a   Yamamoto, Yoshimasa ^a   Newton, Catherine ^a   Friedman, Herman ^a   Klein, Thomas ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABIDIOL; CANNABINOID; CANNABINOL; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG ABUSE; IMMUNE RESPONSE; INFECTION RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; LEGIONELLA PNEUMOPHILA; MORTALITY; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; SPLEEN;

EID: 0031028412     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-214-44071     Document Type: Article

References (18)

1. Klein TW, Newton CA, Widen R, Friedman H. The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses. J Immunopharmacol 7:451-466, 1985.
2. Pross S, Nakano Y, Smith J, Widen R, Rodriguez A, Newton C, Friedman H. Suppressive effect of tetrahydrocannabinol on specific T cell subpopulations in the thymus. Thymus 19:97-104, 1992.
3. Specter S, Rivenbark M, Newton C, Kawakami Y, Lancz G. Prevention and reversal of delta-9-tetrahydrocannabinoI induced depression of natural killer cell activity by interleukin 2. Int J Immunopharmacol 11:63-69, 1989.
4. Klein TW, Newton C, Friedman H. Inhibition of natural killer cell function by marijuana components. J Toxicol Environ Health 20:321-332, 1987.
5. Specter S, Lancz G, Goodfellow D. Suppression of human macro-phage function in vitro by delta-9-tetrahydrocannabinol. J Leukocyte Biol 50:423-126, 1991.
6. Agurell S, Halldin M, Lindgren JE, Ohlsson A, Widman M, Gillespie H, Hollister L. Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man. Pharmacol Rev 38:21-43, 1986.
7. Pertwer R. The evidence for the existence of cannabinoid receptors. Gen Pharmacol 24:811-824, 1993.
8. Devane WA, Dysarz FA, Johnson MR, Melver LS, Howlett AC. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613, 1988.
9. Howlett AC, Champion TM, Wilken GH, Mechoulam R. Stereochemical effects of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29:161-165, 1990.
10. Klein TW, Newton C, Widen RH, Friedman H. Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila. J Pharmacol Exp Ther 267:635-640, 1993.
11. Ryffel B, Mihatsch MJ, Woerly G. Pathology induced by interleukin-6. Int Rev Exp Pathol 34A:79-89, 1993.
12. Friedman F, Widen R, Klein T, Friedman H. Lymphoid cell blastogenesis as an in vitro indicator of cellular immunity to Legionella pneumophila antigens. J Clin Microbiol 19:834-837, 1984.
13. Yamamoto Y, Klein TW, Newton C, Widen R, Friedman H. Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect Immun 56:370-375, 1988.
14. Yamamoto Y, Retzlaff C, He P, Klein TW, Friedman H. Quantitative reverse transcription-PCR analysis of Legionella pneumophila-induced cytokine mRNA in different macrophage populations by high-performance liquid chromatography. Clin Diagn Lab Immunol 2:18-24, 1995.
15. Zhu W, Newton C, Daaka Y, Friedman H, Klein TW. Delta-9-tetrahydrocannabinol (THC) enhances the secretion of interleukin 1 (IL1) from endotoxin stimulated macrophages. J Pharmacol Exp Ther 270:1334-1339, 1994.
16. Klein TW, Newton C, Friedman H. Legionella pneumophila resistance to challenge infection suppressed by the psychoactive marijuana component tetrahydrocannabinol. J Infect Dis 169:1177-1179, 1994.
17. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL6 and related molecules (IL1 and TNF). FASEB J 4:2860-2867, 1990.
18. Ertel W, Morrison MH, Wang P, Ba ZF, Ayala A, Chaudry IH. The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins. Ann Surg 214:141-148, 1991.