Effects of PACAP-38 on the SA nodal pacemaker activity in autonomically decentralized hearts of anesthetized dogs

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 2, 1997, Pages 216-221

  Hirose, Masamichi ^a   Furukawa, Yasuyuki ^a   Nagashima, Yoshito ^a   Yamazaki, Kyouhei ^a   Hoyano, Yuji ^a   Chiba, Shigetoshi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine; Atrial fibrillation; PACAP receptor; Parasympathetic nerve; Sinoatrial node

Indexed keywords

ACETYLCHOLINE; ATROPINE; HEXAMETHONIUM; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NORADRENALIN; PROPRANOLOL; TETRODOTOXIN;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DOG; DOSE RESPONSE; FEMALE; HEART ATRIUM FIBRILLATION; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NONHUMAN; PARASYMPATHETIC NERVE; POSTGANGLIONIC NERVE; PRIORITY JOURNAL; SINOATRIAL CONDUCTION;

ACETYLCHOLINE; ANESTHESIA; ANIMALS; ATRIAL FIBRILLATION; ATROPINE; DOGS; FEMALE; HEART RATE; HEXAMETHONIUM; MALE; NEUROPEPTIDES; PARASYMPATHETIC NERVOUS SYSTEM; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROPRANOLOL; SINOATRIAL NODE; TETRODOTOXIN;

EID: 0031028366     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199702000-00010     Document Type: Article

References (26)

1. Miyata A, Arimura A, Dahl RR, et al. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cell. Biochem Biophys Res Commun 1989;164:567-74.
2. Arimura A, Somogyvari-Vigh A, Miyata A, Mizuno K, Coy DH, Kitada C. Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testis. Endocrinology 1991;129:2787-9.
3. Inagaki N, Yoshida H, Mizuta M, et al. Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc Natl Acad Sci U S A 1994;91:2679-83.
4. Ishizuka Y, Kashimoto K, Mochizuki T, Sato K, Ohshima K, Yanaihara N. Cardiovascular and respiratory actions of pituitary adenylate cyclase-activating polypeptides. Regul Pept 1992;40:29-39.
5. Minkes RK, McMahon TJ, Higuera TR, Murphy WA, Coy DH, Kadowitz PJ. Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines. Am J Physiol 1992;263:H1659-69.
6. Sawangjaroen K, Dallemagne CR, Cross RB, Curlewis JD. Effects of pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on the cardiovascular system in sheep. Peptides 1992;13:1029-32.
7. Masuo Y, Matsumoto Y, Tokito F, Tsuda M, Fujino M. Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Brain Res 1993;611:207-15.
8. Chiba S, Hashimoto K. Sustained atrial fibrillation induced by carbachol, methacholine and bethanechol. Jpn J Pharmacol 1971;21: 167-73.
9. Hashimoto K, Chiba S, Tanaka S, Hirata M, Suzuki Y. Adrenergic mechanism participating in induction of atrial fibrillation by ACh. Am J Physiol 1968;215:1183-91.
10. Levy MN, Ng ML, Zieske H. Functional distribution of the peripheral cardiac sympathetic pathways. Circ Res 1966;19:650-61.
11. Furukawa Y, Narita M, Takei M, Kobayashi O, Haniuda M, Chiba S. Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts. Jpn J Pharmacol 1991;55:381-90.
12. James TN, Nadeau RA. Sinus bradycardia during injections directly to the sinus node artery. Am J Physiol 1963;204:9-18.
13. Loomis TA, Krop S. Auricular fibrillation induced and maintained in animals by acetylcholine or vagal stimulation. Circ Res 1955;3: 390-6.
14. Allessie MA, Lammers WJEP, Bonke AM, Hollen J. Intraatrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog. Circulation 1984;70:123-35.
15. Schuessler RB, Rosenshtraukh LV, Boineau JP, Bromberg BI, Cox JL. Spontaneous tachyarrhythmias after cholinergic suppression in the isolated perfused canine right atrium. Circ Res 1991;69:1075-87.
16. Inoue Y, Furukawa Y, Nakano H, Sawaki S, Oguchi T, Chiba S. Parasympathetic control of right atrial pressure in anesthetized dogs. Am J Physiol 1994;266:H861-6.
17. Yano K, Mitsuoka T, Hano O, Matsumoto M. Effect of bilateral stellectomy on electrical instability of the atrium in the dog with hypokalemia. PACE Pacing Clin Electrophysiol 1992;15:314-23.
18. Spengler D, Waeber C, Pantaloni C, et al. Differential signal transduction by five splice variants of the PACAP receptor. Nature 1993;365:170-5.
19. Tong S, Parfenova H, Shibata M, Zuckerman S, Armstead WM, Leffler CW. Pituitary adenylate cyclase-activating polypeptide dilates cerebral arterioles of newborn pigs. Proc Soc Exp Biol Med 1993;203:343-7.
20. Coumel P. Clinical approach to paroxysmal atrial fibrillation. Clin Cardiol 1990;13:209-12.
21. Kimura C, Ohkubo S, Ogi K, et al. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun 1990;166:81-9.
22. Shen Z, Larson LT, Malmfors G, Abased A, Hakanson R, Sunder F. A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in human intestine: evidence for reduced content in Hirschsprung's disease. Cell Tissue Res 1992;269:369-74.
23. Guijarro LG, Rodriguez-Henche N, Garcia-Lopez E, et al. Receptors for pituitary adenylate cyclase-activating peptide in human liver. J Clin Endocrinol Metab 1995;80:2451-7.
24. Suda K, Smith DM, Ghatei MA, Murphy JK, Bloom SR. Investigation and characterization of receptors for pituitary adenylate cyclase-activating polypeptide in human brain by radioligand binding and chemical crosslinking. J Clin Endocrinol Metab 1991;72:958-64.
25. Chen W, Inui T, Hachiya T, Ochi Y, Nakajima Y, Kajita Y. Stimulatory action of pituitary adenylate cyclase-activating polypeptide (PACAP) on thyroid gland. Biochem Biophys Res Commun 1993;194:923-9.
26. Warren JB, Cockcroft JR, Larkin SW, et al. Pituitary adenylate cyclase-activating polypeptide is a potent vasodilator in humans. J Cardiovasc Pharmacol 1992;20:83-7.