Net effect of inoculum size on antimicrobial action of ampicillin- sulbactam: Studies using an in vitro dynamic model

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 1, 1997, Pages 7-12

  Firsov, Alexander A ^a   Ruble, Matthew ^b   Gilbert, Deborah ^b   Savarino, Daniele ^c   Manzano, Brenda ^c   Medeiros, Antone A ^c   Zinner, Stephen H ^b,d  

^a Department of Pharmacokinetics   (Russian Federation)

^b BROWN UNIVERSITY   (United States)

^c MIRIAM HOSPITAL   (United States)

^d ROGER WILLIAMS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; SULBACTAM;

ANTIMICROBIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; CELL KILLING; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME INACTIVATION; ENZYME INHIBITION; GROWTH CURVE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL;

EID: 0031028130     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.1.7     Document Type: Article

References (17)

1. Blaser, J. 1991. Interactions of antimicrobial combinations in vitro: the relativity of synergism. Scand. J. Infect. Dis. 74(Suppl.):71-79.
2. Blaser, J., B. B. Stone, and S. H. Zinner. 1985. Two compartment kinetic model with multiple artificial capillary units. J. Antimicrob. Chemother. 15(Suppl. A):131-137.
3. Blaser, J., B. B. Stone, and S. H. Zinner. 1985. Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model. Antimicrob. Agents Chemother. 27:343-349.
4. Blaser, J., and S. H. Zinner. 1987. In vitro models for the study of antibiotic activities. Prog. Drug Res 31:349-381. Birkhauser Verlag, Basel.
5. Firsov, A. A., V. M. Chernykh, and S. M. Navashin. 1991. Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model. Antimicrob. Agents Chemother. 34:1312-1317.
6. Firsov, A. A., A. D. Nazarov, and V. M. Chernykh. 1989. Pharmacokinetic approaches to rational antibiotic therapy. In Series: Advances in Science and Engineering, vol. 17. VINITI Publishers, Moscow, Russia. (In Russian.)
7. Firsov, A. A., D. Savarino, M. Ruble, D. Gilbert, B. Manzano, A. A. Medeiros, and S. H. Zinner. 1996. Predictors of the effect of ampicilin-sulbactam against TEM-1 β-lactamase-producing Escherichia coli in an in vitro dynamic model: enzyme activity versus MIC. Antimicrob. Agents Chemother. 40:734-738.
8. Garrod, L. P., H. P. Lambert, F. O'Grady, and P. M. Waterworth. 1981. Antibiotic and chemotherapy, 5th ed., p. 464-504. Churchill Livingstone, Edinburgh, United Kingdom.
9. Gavan, T. L., and A. L. Barry. 1980. Microdilution test procedures, p. 459-462. In E. H. Lennette, A. Balows, W. J. Hausler, Jr., and J. P. Truant (ed.), Manual of clinical microbiology, 3rd ed. American Society for Microbiology, Washington, D.C.
10. Grasso, S. 1985. Historical review of in-vitro models. J. Antimicrob. Chemother. 15(Suppl. A):99-102.
11. Greenwood, D. 1985. Models in the assessment of antimicrobial agents, p. 323-339. In Scientific basis of antimicrobial chemotherapy, 38th Symposium of the Society for General Microbiology. Society for General Microbiology, Cambridge, United Kingdom.
12. Kinishi, T. 1993. Pharmacokinetic profile of antimicrobial agents. II-1. Penicillins, p. 43. In H.-P. Kuemmerle, T. Murakawa, and C. H. Nightingale (ed.), Pharmacokinetics of antimicrobial agents: Principles. Methods. Application. Ecomed Verlags GmbH & Co., Landsberg/Lech, Germany.
13. Murakawa, T. 1993. IV. Pharmacokinetics and therapeutic efficacy. IV-1. In vitro/in vivo kinetic models for evaluating efficacy of antimicrobial agents, p. 165-177. In H.-P. Kuemmerle, T. Murakawa, and C. H. Nightingale (ed.), Pharmacokinetics of antimicrobial agents: Principles. Methods. Application. Ecomed Verlags GmbH & Co., Landsberg/Lech, Germany.
14. Sanfilippo, A., and L. Mazzoleni. 1974. Antibacterial activity of aminosidine and of beta-lactamic antibiotics. Farm. Ed. Prat. 29:21-26.
15. Satta, G., G. Cornaglia, G. Foddis, and R. Pompei. 1988. Evaluation of ceftriaxone and other antibiotics against Escherichia coli. Pseudomonas aeruginosa, and Streptococcus pneumoniae under in vitro conditions simulating those of serious infections. Antimicrob. Agents Chemother. 32:55-560.
16. Tisdale, J. E., M. T. Pasko, and J. M. Mylotte. 1989. Antipseudomonal activity of simulated infusions of gentamicin alone or with piperacillin assessed by serum bactericidal rate and area under the killing curve. Antimicrob. Agents Chemother. 33:1500-1505.
17. White, C. A., and R. D. Toothaker. 1985. Influence of ampicillin elimination half-life on in vitro bactericidal effect. J. Antimicrob. Chemother. 15(Suppl. A):257-260.