'Hepatoma specific' alphafetoprotein may permit preclinical diagnosis of malignant change in patients with chronic liver disease

British Journal of Cancer

Volumn 75, Issue 2, 1997, Pages 236-240

  Johnson, P J ^a   Leung, N ^a   Cheng, P ^a   Welby, C ^a   Leung, W T ^a   Lau, W Y ^a   Yu, S ^a   Ho, S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Alphafetoprotein; Hepatoma; Isoform

Indexed keywords

ALPHA FETOPROTEIN; ISOPROTEIN;

ADULT; ARTICLE; CANCER DIAGNOSIS; CHRONIC LIVER DISEASE; CLINICAL TRIAL; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; ECHOGRAPHY; FEMALE; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL;

EID: 0031027946     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.39     Document Type: Article

References (26)

1. Alpert E and Feller ER (1978) Alpha-fetoprotein (AFP) in benign liver disease: evidence that normal liver regeneration does not induce AFP synthesis. Gastroenterology 74: 856-858
2. Aoyagi Y, Suzuki Y, Isemuna M, Soga K, Ozaki T, Ichida T, Inoue K, Sasaki H and Ichida F (1984) Differential reactivity of alphafetoprotein with lectins and evaluation of its usefulness in the diagnosis of hepatocellular carcinoma. Gann 75: 809-815
3. Aoyagi Y, Isemura M, Yosizawa Z, Suzuki Y, Sekine C, Ono T and Ichida F (1985) Fucosylation of serum-alpha-fetoprotein in patients with primary hepatocellular carcinoma. Biochim Biophys Acta 830: 217-223
4. Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M and Asakura H (1993) Carbohydrate structures of human alpha-fetoprotein patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. Br J Cancer 67: 486-492
5. Bloomer JR, Waldmann TA, Mcintire KR and Klatskin G (1975) Alpha-fetoprotein in nonneoplastic hepatic disorders. JAMA 233: 38-41
6. Buamah PK, Harris R, James DFW and Skillen AW (1986) Lentil lectin-reactive alphafetoprotein in the differential diagnosis of benign and malignant liver disease. Clin Chem 32: 2083-2084
7. Burditt LJ, Johnson MM, Johnson PJ and Williams R (1994) Detection of hepatocellular carcinoma-specific alpha-fetoprotein by isoelectric focusing. Cancer 74: 25-29
8. Colombo M, Franchis DR, Ninno ED, Sangiovanni A, Fazio CD, Tommasini M, Donato MF, Piva A, Carlo VD and Dioguardi N (1991) Hepatocellular carcinoma in Italian patents with cirrhosis. N Eng J Med 325 675-680
9. Curley S, Izzo F, Gallipoli A, Bellis MD, Cremona F and Parrsi V (1995) Identification and screening of 416 patients with chronic hepatitis at high risk to develop hepatocellular carcinoma. Ann Surg 222: 375-383
10. Du M-Q, Hutchinson WL, Johnson PJ and Williams R (1991) Differential alpha-fetoprotein lectin binding in hepatocellular carcinoma: diagnostic ultility at low serum levels. Cancer 67: 476-480
11. Govindarajan S, Fong TL and Aschavai M (1987) Concanavalin A affinity of alpha-fetoprotein. Am J Clin Pathol 88: 722-724
12. Ho S, Cheng P, Yuen J, Chan A, Leung N, Yeo W, Leung T, Lau WY, Li AKC and Johnson PJ (1996) Isoelectric focusing of alpha-fetoprotein in patients with hepatocellular carcinoma: frequency of specific banding patterns at nondiagnostic levels. Br J Cancer 73: 985-989
13. Johnson PJ, Ho S, Cheng P, Chan A, Leung WT and Yuen J (1995) Germ cell tumours express a specific alpha-fetoprotein variant detectable by isoelectric focusing. Cancer 75: 1663-1668
14. Johnson PJ, Portmann B and Williams R (1978) Alpha-fetoprotein concentration measured by radioimmunoassay in the diagnosing and excluding of hepatocellular carcinoma. Br Med J 2: 661-663
15. Johnson PJ and Williams R (1980) Serum alpha-fetoprotein estimations and doubling time in hepatocellular carcinoma: influence of therapy and possible value in early detection. J Natl Cancer Int 64: 1329-1332
16. Johnson PJ and Williams R (1987) Cirrhosis and the aetiology of hepatocellular carcinoma. J Hepatol 4: 140-147
17. Kew MC and Popper H (1984) Relationship between hepatocellular carcinoma and cirrhosis. Sem Liver Dis 4: 136-146
18. Krusius T and Ruoslahti E (1982) Carbohydrate structure of the concanavalin A molecular variants of AFP. J Biol Chem 257: 3453-3458
19. Lee HS, Chung YH and Kim CY (1991) Specificity of serum alpha-fetoprotein in HBsAg+ and HBsAg- patients in the diagnosis of hepatocellular carcinoma. Hepatology 14: 68-72
20. Liaw Y-F, Tai D-I, Chu C-M Lin DY, Sheen IS, Chen JJ and Pao CC (1986) Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. A prospective study. Gastroenterology 90: 263-267
21. Lok ASF and Lai CL (1989) α-fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in early detection of hepatocellular carcinoma. Hepatology 9: 110-115
22. Oka H, Kurioka N, Kim K, Kanno T, Tetsuo K, Mizoguchi Y and Kobayashi K (1990) Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis. Hepatology 12: 680-687
23. Oka H, Tamori A, Kuroki T, Kobayashi K and Yamamoto S (1994) Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology 19: 61-66
24. Sato Y, Nakata K, Kato Y, Shima M, Ishi N, Koji T, Taketa K, Endo Y and Nagataki S (1993) Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 328: 1802-1806
25. Sawabu N and Hattori N (1987) Serological tumor markers in hepatocellular carcinoma. In Neoplasms of the Liver, Okuda K and Ishak KG (eds), pp. 227-238. Springer-Verlag: Tokyo
26. Taketa K, Izumi M and Ichikawa E (1983) Distinct molecular species of human alpha-fetoprotein due to differential affinities to lectins. Ann N Y Acad Sci 417: 61-68