Ischaemia-induced loss or reversal of the effects of the class I antiarrhythmic drugs on vulnerability to fibrillation

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 523-529

  Aupetit, Jean François ^a   Loufoua Moundanga, Joseph ^a   Faucon, Georges ^a   Timour, Quadiri ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Antiarrhythmic drugs; Disopyramide; Flecainide; Lignocaine; Myocardial ischaemia; Ventricular fibrillation

Indexed keywords

ANTIARRHYTHMIC AGENT; DISOPYRAMIDE; FLECAINIDE; LIDOCAINE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; CORONARY VESSELS; DISOPYRAMIDE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; FLECAINIDE; HEART CONDUCTION SYSTEM; INJECTIONS, INTRAVENOUS; LIDOCAINE; MALE; MYOCARDIAL ISCHEMIA; SWINE; VENTRICULAR FIBRILLATION;

EID: 0031027920     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700926     Document Type: Article

References (49)

1. ANDERSON, J.L., STEWART, J.R., PERRY, B.A., VAN HAMERSVELD, D.D., JOHNSON, T.A. & CONARD, G.J. (1981). Oral flecainide acetate for the treatment of ventricular arrhythmias. N. Engl. J. Med., 305, 473-476.
2. ANTMAN, E.M. & BERLIN, J.A. (1992). Declining incidence of ventricular fibrillation in myocardial infarction: implications for the prophylactic use of lignocaine. Circulation, 86, 764-773.
3. AUPETIT, J.F., TIMOUR, Q., CHEVREL, G., LOUFOUA-MOUNDANGA, J., OMAR, S. & FAUCON, G. (1993a). Attenuation of the ischaemia-induced fall of electrical threshold for fibrillation by a calcium antagonist, diltiazem. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 509-514.
4. AUPETIT, J.F., TIMOUR, Q., LARBRE, J.P., LOUFOUA-MOUNDANGA, J., KIOUEH, I., LOPEZ, M. & FAUCON, G. (1993b). Arrhythmogenicity of antiarrhythmic drugs and intraventricular conduction disorders: possible aggravation by myocardial ischaemia. Study in the porcine in situ heart. Cardiovasc. Drugs Ther., 7, 217-223.
5. AUPETIT, J.F., TIMOUR, Q., LOUFOUA-MOUNDANGA, J., BARRAL-CADIÈRE, L., LOPEZ, M., FREYSZ, M & FAUCON, G. (1995). Profibrillatory effects of lignocaine in the acutely ischemic porcine heart. J. Cardiovasc. Pharmacol., 25, 810-816.
6. BADUI, E., GARCIA-RUBI, D. & ESTANOL, B. (1981). Inadvertent massive lignocaine overdose causing temporary complete heart block in myocardial infarction. Am. Heart. J., 102, 801-803.
7. BERGEY, J.L., NOCELLA, K. & McCOLLIN, J.D. (1982). Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lignocaine. Eur. J. Pharmacol., 81, 205-216.
8. + accumulation. Eur. J. Pharmacol., 127, 261-265.
9. CAMPBELL, T.U. & VAUGHAN-WILLIAMS, E.M. (1983). Voltage and time-dependent depression of maximum rate of depolarization of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide. Cardiovasc. Res., 17, 251-258.
10. CARDIAC ARRHYTHMIA SUPPRESSION TRIAL (CAST) INVESTIGATORS. (1989). Preliminary report: effect on encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N. Engl. J. Med., 321, 406-412.
11. CARDIAC ARRHYTHMIA SUPPRESSION TRIAL (CAST) INVESTIGATORS. (1991). Mortality and morbidity in patients receiving encainide. N. Engl. J. Med., 324, 781-788.
12. CARSON, D.L. & DRESEL, P.E. (1983). Effect of lignocaine on ventricular conduction in acutely ischemic dog heart. J. Cardiovasc. Pharmacol., 5, 357-363.
13. CLUSIN, W.T., BRISTOW, M.R., KARAGUEUZIAN, H.S., KATZUNG, B.G. & SCHROEDER, J.S. (1982). Do calcium-dependent ionic currents mediate ischemic ventricular fibrillation? Am. J. Cardiol., 49, 606-612.
14. CORABOEUF, E. (1978). Ionic basis of electrical activity in cardiac tissues. Am. J. Physiol., 234, H101-H116.
15. +, pH and activation in the pig. Circulation, 72, 922-932.
16. GAMBLE, O.W. & COHN, K. (1972). Effect of propranolol, procainamide and lignocaine on ventricular automaticity and reentry in experimental myocardial infarction. Circulation, 46, 498-506.
17. GERSTENBLITH, G., SCHERLAG, B.J., HOPE, R.R. & LAZZARA, R. (1978). Effect of lignocaine on conduction in the ischemic His-Purkinje system of dogs. Am. J. Cardiol., 42, 587-591.
18. GETTES, L.S., CASCIO, W.E., JOHNSON, T. & FLEET, W.F. (1991). Local myocardial biochemical and ionic alterations during myocardial ischemia and reperfusion. Drugs, 42 (Suppl 1), 7-13.
19. HAGAR, J.M., HALE, S.L. & KLONER, R.A. (1991). Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ. Res., 68, 61-68.
20. HARRISON, D.C., SPROUSE, J.H. & MORROW, A.G. (1963). The antiarrhythmic properties of lignocaine and procainamide. Clinical and physiologic studies of their cardiovascular effects in man. Circulation, 28, 486-491.
21. HEIJNIS, J.B., CORONEL, R. & VAN ZWIETEN, P.A. (1991). The effects of calcium antagonists on extracellular potassium accumulation during global ischemia in isolated perfused rat hearts. Cardiovasc. Drugs Ther., 5, 1035-1041.
22. HINE, L.K., LAIRD, N., HEWITT, P. & CHALMERS, T.C. (1989). Metaanalytic evidence against prophylactic use of lignocaine in acute myocardial infarction. Arch. Intern. Med., 149, 2694-2698.
23. HOFFMAN, B.F. & ROSEN, M.R. (1981). Cellular mechanisms for cardiac arrhythmias. Circ. Res., 49, 1-15.
24. JAILLON, P., SCHNITTGER, I., GRIFFIN, J.C. & WINKLE, R.A. (1980). The relationship between the repetitive extrasystole threshold and the ventricular fibrillation threshold in the dog. Non-parallel changes following pharmacological intervention. Circ. Res., 46, 499-605.
25. JANSE, M.J. & WIT, A.L. (1989). Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol. Rev., 69, 1049-1169.
26. KLEBER, A.G., JANSE, M.J., WILMS-SCHOPMAN, F.J.G., WILDE, A.A.M., CORONEL, R. (1986). Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. Circulation, 73, 189-198.
27. LANG, J., TIMOUR, Q., AUPETIT, J.F., LANCON, J.P., LAKHAL, M. & FAUCON, G. (1988). Frequency- and time-dependent depression of ventricular distal conduction by two novel antiarrhythmic drugs, cibenzoline and flecainide. Arch. Int. Pharmacodyn., 293, 97-108.
28. LOUFOUA, J., AUPETIT, J.F., FREYSZ, M., OMAR, S., TIMOUR, Q. & FAUCON, G. (1993). Enhancement by class I antiarrhythmic drugs of the risk of fibrillation of the ischaemic myocardium. Fund. Clin. Pharmacol., 7, 370 (Abstract).
29. LYONS, C.J., BURGESS, M.T. & ABILDSKOV, J.A. (1977). Effects of acute hyperkalemia on cardiac excitability. Am. Heart. J., 94, 755-763.
30. MACMAHON, S., COLLINS, R., PETO, R., KOSTER, R.W. & YUSUF, S. (1988). Effects of prophylactic lignocaine in suspected acute myocardial infarction: an overview of results from randomized, controlled trials. J. Am. Med. Assoc., 260, 1910-1916.
31. MURRY, C.E., JENNINGS, R.B. & REIMER, K.A. (1986). Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74, 1124-1136.
32. NATTEL, S. (1991). Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance. Drugs, 41, 672-701.
33. PATTERSON, E., GIBSON, J.K. & LUCCHESI, B.R. (1982). Electrophysiologic actions of lignocaine in a canine model of chronic myocardial ischemic damage. Arrhythmogenic actions of lignocaine. J. Cardiovasc. Pharmacol., 4, 925-934.
34. PATTERSON, E., GIBSON, J.K. & LUCCHESI, B.R. (1988). Antiarrhythmic and arrhythmogenic actions of methyllignocaine during the recovery phase after canine myocardial infarction. Pharmacology, 36, 73-83.
35. REUTER, H. (1984). Ion channels in cardiac cell membrane. Ann. Rev. Physiol., 46, 473-484.
36. ROELAND, J., KLOOTWIJK, P., LUBSEN, J. & JANSE, M.J. (1984). Sudden death during long-term ambulatory monitoring. Eur. Heart. J., 5, 7-20.
37. SHIKI, K. & HEARSE, D.J. (1987). Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias. Am. J. Physiol., 253, H1470-H1476.
38. TIMOUR, Q., AUPETIT, J.F., CHEVREL, G., LOUFOUA-MOUNDANGA, J., OMAR, S. & FAUCON, G. (1994). Time course of electrical fibrillation threshold in brief periods of myocardial ischemia and genesis of fibrillation: role of calcium. Cardiovasc. Drugs Ther., 8, 877-879.
39. TIMOUR, Q., AUPETIT, J.F., LOUFOUA-MOUNDANGA, J., BERTRIX, L., FREYSZ, M. & FAUCON, G. (1989). Ventricular and atrial electrophysiological effects of a Ic antiarrhythmic drug, cibenzoline, in the innervated dog heart. Role of sodium and calcium channels. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 338-344.
40. TIMOUR, Q., AUPETIT, J.F., LOUFOUA-MOUNDANGA, J., GERENTES-CHASSAGNE, I., KIOUEH, I. & FAUCON, G. (1991). Class Ic antiarrhythmic drugs and myocardial ischaemia. Study in the pig heart in situ. Naunyn-Schmiedeberg's Arch. Pharmacol., 343, 645-651.
41. TIMOUR, Q., BERTRIX, L., BOUZOUITA, K., LANG, J. & FAUCON, G. (1983). Study of the ventricular antifibrillatory effects of calcium channel blocking agents in comparison with lignocaine in canine normal heart in situ. Arch. Int. Pharmacodyn., 261, 238-248.
42. TIMOUR, Q., LARBRE, J.P., KIOUEH, I., AUPETIT, J.F., LOUFOUA-MOUNDANGA, J., VIALLE, A. & FAUCON, G. (1992). Calcium channel modulators and susceptibility to ischaemic ventricular fibrillation: modification of cellular calcium overload. Arch. Int. Pharmacodyn., 315, 30-46.
43. VAUGHAN-WILLIAMS, E.M. (1984). A classification of antiarrhythmic actions reassessed after a decade of new drugs. J. Clin. Pharmacol., 24, 129-147.
44. VEGH, A., KOMORI, S., SZEKERES, L. & PARRAT, J.R. (1992). Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats. Cardiovasc. Res., 26, 487-495.
45. VELEBIT, V., PODRID, P., LOWN, B., COHEN, B.H. & GRABOYS, T.B. (1982). Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs. Circulation, 65, 886-895.
46. WEIDMANN, S. (1955). The effect of the cardiac membrane potential on the rapid availability of sodium carrying system. J. Physiol., 127, 213-214.
47. WINKLE, R.A., MASON, J.W., GRIFFIN, J.C. & ROSS, D. (1981). Malignant ventricular tachyarrhythmias associated with the use of encainide. Am. Heart. J., 102, 857-867.
48. WIT, A.L. & CRANEFIELD, P.F. (1978). Re-entrant excitation as a cause of cardiac arrhythmias. Am. J. Physiol., 235, H1-H17.
49. YE, V.Z., WYSE, K.R. & CAMPBELL, T.S. (1993). Lignocaine shows greater selective depression of depolarized and acidotic myocardium than propafenone: possible implications for proarrhythmia. J. Cardiovasc. Pharmacol., 21, 47-55.