Effects of imidazolines on noradrenaline release in brain: An investigation into their relationship to imidazoline, α2 and H3 receptors

Neurochemistry International

Volumn 30, Issue 1, 1997, Pages 73-83

  Schlicker, E ^a   Fink, K ^a   Kathmann, M ^a   Molderings, G J ^a   Gothert M ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 2 (2 IMIDAZOLIN 2 YLAMINO)ISOINDOLINE; AGANODINE; ALPHA 2 ADRENERGIC RECEPTOR; CIRAZOLINE; CLONIDINE; HISTAMINE H3 RECEPTOR; IMIDAZOLINE RECEPTOR; MOXONIDINE; NORADRENALIN; PHENOXYBENZAMINE; RAUWOLSCINE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BRAIN SYNAPTOSOME; FEMALE; MEDULLA OBLONGATA; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RABBIT; RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BRAIN; CEREBRAL CORTEX; CLONIDINE; ELECTRIC STIMULATION; IMIDAZOLES; MALE; MEDULLA OBLONGATA; NOREPINEPHRINE; PERFUSION; RABBITS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, DRUG; RECEPTORS, HISTAMINE H3; TRITIUM;

EID: 0031027666     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00045-9     Document Type: Article

References (36)

1. Bousquet, P., Feldman, J. and Schwartz, J. (1984) Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230, 232-236.
2. Bousquet, P., Feldman, J., Tibirica, E., Bricca, G., Greney, H., Dontenwill, M., Stutzmann, J. and Belcourt, A. (1992) Imidazoline receptors. A new concept in central regulation of the arterial blood pressure. Am. J. Hypertension 5, 47S-50S.
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt. Biochem. 72, 248-254.
4. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br. J. Pharmacol. 99, 803-809.
5. 2 sites. J. Pharmacol. Exp. Ther. 272, 681-688.
6. 3H]noradrenaline release from rat brain cortex synaptosomes. Brain Res. 185, 399-408.
7. Ernsberger, P., Giuliano, R., Willette, R. N. and Reis, D. J. (1990) Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253, 408-418.
8. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
9. 1-imidazoline receptors.. J. Cardiovasc. Pharmacol. 20, Suppl., S1-S10.
10. Feldman, J., Tibirica, E., Bricca, G., Dontenwill, M., Belcourt, A. and Bousquet, P. (1990) Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol. 100, 600-604.
11. 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves. Naunyn-Schmiedeberg's Arch. Pharmacol. 348, 127-133.
12. 2-receptors in rabbit iris. Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 394-401.
13. 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives. Naunyn-Schmiedeberg's Arch. Pharmacol. 343, 271 282.
14. Göthert, M., Molderings, G. J., Fink, K. and Schlicker, E. (1995) α-Adrenoceptor-independent inhibition by imidazolines and guanidines of noradrenaline release from peripheral, but not central noradrenergic neurones. Ann. N.Y. Acad. Sci. 763, 405-419.
15. 2-adrenoceptors and imidazoline binding sites: distribution of imidazoline binding sites in rat brain. Brain Res. 514, 15-21.
16. 3 receptor model. Naunyn-Schmiedeberg's Arch. Pharmacol. 348, 498-503.
17. 3H]rilmenidine in membranes from rat cerebral cortex. Eur. J. Pharmacol. 218, 101-108.
18. 2-adrenergic binding sites in basolateral membranes from human kidney. Eur. J. Pharmacol.-Mol. Pharmacol. Sect. 206, 23-31.
19. Limberger, N., Hölting, T. and Starke, K. (1987) Protection of presynaptic α-adrenoceptors against irreversible blockade by phenoxybenzamine: preservation of the modulatory effects of exogenous noradrenaline and yohimbine. Naunyn-Schmiedeberg's Arch. Pharmacol. 336, 155-160.
20. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
21. Mallard, N. J., Hudson, A. L. and Nutt, D. J. (1992) Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain. Br. J. Pharmacol. 106, 1019-1027.
22. McPherson, G. A., Molenaar, P., Raper, C. and Malta, E. (1983) Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program. J. Pharmacol. Methods 10, 231-241.
23. 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol. Pharmacol. 35, 324-330.
24. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J. Pharmacol. Exp. Ther. 264, 1187-1197.
25. 2-imidazoline binding sites. Naunyn-Schmiedeberg's Arch. Pharmacol. 351, 507-516.
26. Molderings, G. J., Hentrich, F. and Göthert, M. (1991) Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 344, 630-638.
27. Molderings, G. J., Michel, M. C., Göthert, M., Christen, O. and Schäfer, S. G. (1992) Imidazolrezeptoren: Angriffsort einer neuen Generation von antihypertensiven Arzneimitteln. Aktueller Stand und Zukunftsperspektiven. Dtsch. Med. Wschr. 117, 67-71.
28. 1-imidazoline sites in bovine adrenal medullary membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 348, 70-76.
29. Molderings, G. J., Kathmann, M., Schlicker, E. and Göthert, M. (1994) Involvement of presynaptic imidazoline receptors in the modulation of noradrenaline release in the rabbit aorta. J. Autonom. Pharmacol. 14, Suppl., 22.
30. 2-imidazoline sites. Naunyn-Schmiedeberg's Arch. Pharmacol. 350, 252-257.
31. Reichenbacher, D., Reimann, W. and Starke, K. (1982) α-Adrenoceptor-mediated inhibition of noradrenaline release in rabbit brain cortex slices. Receptor properties and role of the biophase concentration of noradrenaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 319, 71-77.
32. 3 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 633-638.
33. Schlicker, E., Fink, K., Molderings, G. J. and Göthert, M. (1995) Effects of imidazolines and of aganodine on nor-adrenaline release in the CNS. Naunyn-Schmiedeberg's Arch. Pharmacol. 351, Suppl., R137.
34. Starke, K., Göthert, M. and Kilbinger, H. (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol. Rev. 69, 864-989.
35. Taube, H. D., Starke, K. and Borowski, E. (1977) Presynaptic receptor systems on the noradrenergic neurones of rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 299, 123-141.
36. 2A in the rabbit. Naunyn-Schmiedeberg's Arch. Pharmacol. 348, 35-45.