Prevention of hepatic tumor metastases in rats with herpes viral vaccines and γ-interferon

Journal of Clinical Investigation

Volumn 99, Issue 4, 1997, Pages 799-804

  Karpoff, Howard M ^a   D'Angelica, Michael ^a   Blair, Sarah ^a   Brownlee, Michael D ^c   Federoff, Howard ^b   Fong, Yuman ^a,d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

GM CSF; hepatectomy; HSV; IL 2; liver

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERPES VACCINE; INTERLEUKIN 2;

ANIMAL MODEL; ARTICLE; CANCER IMMUNOLOGY; CANCER INHIBITION; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOMODULATION; INTRAPERITONEAL DRUG ADMINISTRATION; KUPFFER CELL; LIVER CARCINOMA; MALE; METASTASIS INHIBITION; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT;

EID: 0031027506     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119226     Document Type: Article

References (34)

1. Lotze, M.T., J.C. Flickinger, and B.I. Car. 1993. Hepatobiliary neoplasms. In Principles of Oncology. V.T. Devita, S. Hellman, and S.A. Rosenberg, editors. J.B. Lippincott Co., Philadelphia. 883-914.
2. Zhou, X.D., Y.Q. Yu, Z.Y. Tang, B.H. Yang, J.Z. Lu, Z.Y. Lin, Z.C. Ma, D.B. Xu, B.H. Zhang, Y.X. Zheng, et al. 1993. Surgical treatment of recurrent hepatocellular carcinoma. Hepato-Gastroenterology. 40:333-336.
3. Loizidou, M.C., R.J. Lawrance, S. Holt, N.J. Carty, A.J. Cooper, P. Alexander, and I. Taylor. 1991. Facilitation by partial hepatectomy of tumor growth within the rat liver following intraportal injection of syngeneic tumor cells. Clin. Exp. Metastasis. 9:335-349.
4. Karpoff, H.M., C. Tung, B. Ng, and Y. Fong. 1996. γ-Interferon protects against hepatic tumor growth in rats by increasing Kupffer cell tumoricidal activity. Hepatology. 24(2):374-379.
5. Rubin, J.T. 1993. Interleukin-2: Its biology and clinical application in patients with cancer. Cancer Invest. 11:460-472.
6. Jones, T., A. Stern, and R. Lin. 1994. Potential role of granulocyte-macrophage colony-stimulating factor as a vaccine adjuvant. [Review]. Eur. J. Clin. Microbiol. Infect. Dis. 13(2):47S-53S.
7. Rosenberg, S.A. 1990. Adoptive immunotherapy for cancer. Sci Am. 262: 34-39.
8. Bubenik, J., N.N. Voitenok, J. Kieler, V.S. Prassolov, P.M. Chumakov, D. Bubenikova, J. Simova, and T. Jandlova. 1988. Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumors in nu/nu mice. Immunol. Lett. 19:279-283.
9. Gansbacher, B., L. Zier, B. Daniels, K. Cronin, R. Bannerji, and E. Gilboa. 1990. Interleukin-2 gene transfer into tumor cells abrogrates tumorigenicity and induces protective immunity. J. Exp. Med. 172:1217-1224.
10. Vieweg, J., F.M. Rosenthal, R. Bannerji, W.D.W. Heston, W. Fair, B. Gansbacher, and E. Gilboa. 1994. Immunotherapy of prostate cancer in the Dunning rat model: Use of cytokine gene modified tumor vaccines. Cancer Res. 54:1760-1765.
11. Dranoff, G., E. Jaffee, A. Lazenby, P. Golumbek, H. Levitsky, K. Brose, V. Jackson, H. Hamada, D. Pardoll, and R.C. Mulligan. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting antitumor immunity. Proc: Nat. Acad. Sci. USA. 90:3539-3543.
12. Abe, J., H. Wakimot, Y. Yoshida, M. Aoyagi, K. Hirakawa, and H. Hamada. 1995. Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: comparison of adenovirus-and retrovirus-mediated genetic transduction. J. Cancer Res. Clin Oncol. 121:587-592.
13. Geller, A.I., K. Keyomarsi, J. Bryan, and A.B. Pardee. 1990. An efficient deletion mutant packaging system for defective herpes simplex virus vectors: Potential applications to human gene therapy and neuronal physiology. Proc. Nat. Acad. Sci. USA. 87:8950-8954.
14. Lu, B., and H.J. Federoff. 1995. Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Hum. Gene Ther. 6:419-428.
15. Mesri, E.A., H.J. Federoff, and M. Brownlee. 1995. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ. Res. 76:161-167.
16. Black, P.L., H. Phillips, H.R. Tribble, R. Pennington, M. Schneider, and J.E. Talmadge. 1993. Antitumor response to recombinant murine interferon gamma correlates with enhanced immune function of organ-associated, but not recirculating cytolytic T lymphocytes and macrophages. Cancer Immunol. Immunother. 37:299-306.
17. Kawada, N., Y. Mizoguchi, K. Kobayashi, S. Morisawa, T. Monna, and S. Yamamoto. 1991. Interferon gamma modulates production of Interleukin 1 and tumor necrosis factor by murine Kupffer cells. Liver. 11:42-47.
18. Kutteh, W.H., W.E. Rainey, and B.R. Carr. 1991. Regulation of Interleukin-6 production in human fetal Kupffer cells. Scand. J. Immunol. 33:607-613.
19. West, M.A., G.A. Keller, F.B. Xerra, and R.L. Simmons. 1985. Killed Escherichia coli stimulates macrophage mediated alterations in hepatocellular function during in vitro coculture: a mechanism of altered liver function in sepsis. Infect. Immun. 49:563-569.
20. Johnson, P., A. Miyanohara, F. Levine, T. Cahill, and T. Friedmann. 1992. Cytotoxicity of a replication-defective mutant of herpes simplex virus type I. J. Virol. 66:2952-2965.
21. Patterson, T., and R. Everett. 1990. A prominent serine-rich region in Vmw175, the major transcription regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture. J. Gen. Virol. 71:1775-1783.
22. Geschwind, M., B. Lu, and H. Federoff. 1994. Expression of neurotrophic genes from herpes simplex virus type I vectors modifying neuronal phenotype. In Providing Pharmacological Access to the Brain: Alternative Approaches. T.R. Flanagan, D.F. Emerich, and S.R. Winn, editors. Academic Press, New York. 462-482.
23. Picardo, A., Y. Fong, H.M. Karpoff, S. Yeh, L.H. Blumgart, and M.F. Brennan. 1996. Factors influencing hepatocyte trafficking during allogenic hepatocyte transplantation: improved liver sequestration with isolated perfusion. J. Surg. Res. 63:452-459.
24. Balemans, L.T.M., V. Mattijssen, P.A. Sterenbertg, B.E.M. Van Driel, P.M.M. De Mulder, and W.D. Otter. 1993. Locoregional therapy with polyethylene-glycol-modified interleukin-2 of an intradermally growing hepatocellular carcinoma in the guinea pig induces T-cell-mediated antitumor activity. Cancer Immunol. Immunother. 37:7-14.
25. Ley, V., P. Langlade-Demoyen, P. Kourilsky, and E. Larrson-Sciard. 1991. Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo. Eur. J. Immunol. 21:851-854.
26. Schuurman, B., G. Heuff, R.H. Beelan, and S. Meyer. 1994. Enhanced killing capacity of human Kupffer cells after activation with human granulocyte/macrophage-colony stimulating factor and interferon gamma. Cancer Immunol. Immunother. 39:179-184.
27. Miyanohara, A., P.A. Johnson, R.L. Elam, Y. Dai, J.L. Witztum, I.M. Verma, and T. Friedman. 1992. Direct gene transfer to the liver with Herpes Simplex Virus Type 1 vectors: Transient production of physiologically relevant levels of circulating factor IX. New Biol. 4:238-246.
28. Yamashita, R., T. Hiraoka, I. Kamimoto, and Y. Miyauchi. 1986. Prevention of growth of metastases in rat liver by perioperative immunoactivation. Cancer Res. 46:3138-3141.
29. Pearson, H.J., J. Anderson, J. Chamberlain, and P.R.F. Bell. 1986. The effect of Kupffer cell stimulation or depression on the development of liver metastases in the rat. Cancer Immunol. Immunother. 23:214-216.
30. Xhang, F., A. zur Hausen, M. Grewe, and K. Decker. 1994. Rat liver macrophages express the 55kd tumor necrosis factor receptor, modulation by interferon-gamma, lipopolysaccharide and tumor necrosis factor-alpha. Biol. Chem. Hoppe-Seylar. 375:248-254.
31. Margolin, K.A., J.H. Doroshow, L.A. Leong, R.J. Morgan, J. Rashko, G. Somlo, B. Mills, D. Goldberg, and I. Sniecinski. 1992. Phase I trial of interleukin-2 plus gamma-interferon. J. Immunol. 11:50-55.
32. Iwanuma, Y., K. Kato, H. Yagita, and K. Okumura. 1995. Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene. Cancer Immunol. Immunother. 40:17-23.
33. Raper, S.E., M. Grossman, D.J. Rader, J.G. Theone, B.J. Clark, III, D.M. Kolansky, D.W.M. Muller, and J.M. Wilson. 1996. Safety and feasibility of liver directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann. Surg. 223:116-126.
34. Tung, C., H.J. Federoff, M. Brownlee, H. Karpoff, T. Weigel, M.F. Brennan, and Y. Fong. 1996. Rapid production of IL-2 secreting tumor cells by HSV-mediated gene transfer: Implications for autologous vaccine production. Hum. Gene Ther. 7:2217-2221.