Intestinal absorption of captopril and two thioester analogs in rats and dogs

Biopharmaceutics and Drug Disposition

Volumn 18, Issue 1, 1997, Pages 25-39

  Morrison, R A ^a   Kripalani, K J ^a   Marino, A M ^a   Dean, A V ^a   Migdalof, B H ^a,b   Weinstein, S H ^a   Jain, N B ^a   Bathala, M S ^a   Singhvi, S M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Bradley Pharmaceuticals Inc   (United States)

Author keywords

absorption; captopril; dogs; GI sites; rats; S benzoyl prodrug

Indexed keywords

CAPTOPRIL; S BENZOYLCAPTOPRIL; SQ 25868; SQ 26284; UNCLASSIFIED DRUG; ZOFENOPRIL; ZOFENOPRILAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; DOG; DRUG ABSORPTION; DRUG STRUCTURE; DRUG TISSUE LEVEL; GASTROINTESTINAL TRACT; INTESTINE ABSORPTION; INTRAGASTRIC DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; NONHUMAN; RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BIOTRANSFORMATION; CAPTOPRIL; CHROMATOGRAPHY, THIN LAYER; DOGS; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 0031027370     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199701)18:1<25::AID-BDD998>3.0.CO;2-T     Document Type: Article

References (10)

1. J. Brennan, D. O'Donnell, M. Zinny, N. Jain, E. Ivashkiv and M. Arnold, The comparative bioavailabity of captopril after colonic infusion and oral administration in healthy subjects. Clin. Pharm., 49, 131 (1991).
2. I. R. Wilding, S. S. Davis, M. Bakhshee, H. N. E. Stevens, R. A. Sparrow and J. Brennan, Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation. Pharm. Res., 9, 654-657 (1992).
3. N. B. Jain and M. R. Patel, U. S. Patent 4 505 890, 1985.
4. B. H. Migdalof, S. M. Singhvi and K. J. Kripalani, Thin-layer radiochromatographic determination of captopril (SQ 14,225) and its disulfide dimer metabolite in blood. J. Liq. Chromatogr., 3, 857-865 (1980).
5. M. S. Bathala, S. H. Weinstein, F. S. Meeker, S. M. Singhvi and B. H. Migdalof, Quantitative determination of captopril in blood and captopril and its disulfide metabolites in plasma by gas chromatography. J. Pharm. Sci., 3, 340-344 (1984).
6. P. R. Bieck (Ed.), Colonic Drug Absorption and Metabolism, Dekker, New York, 1993, pp 59, 109.
7. M. Hu and G. Amidon, Passive and carrier-mediated intestinal absorption components of captopril. J. Pharm. Sci., 77, 1007-1011 (1988).
8. B. H. Migdalof, M. J. Antonaccio, D. N. McKinstry, S. M. Singhvi, S. J. Lan, P. Egli and K. J. Kripalani, Captopril, pharmacology, metabolism and disposition. Drug Metab. Rev., 15, 841-869 (1980).
9. Data on file at Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ.
10. J. E. Foley and M. A. Stern, Data on file (Study No. 19,430-1), Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ.