메뉴 건너뛰기




Volumn 17, Issue 3, 1997, Pages 1224-1235

Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; DNA SYNTHESIS; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; GENETIC CODE; MOUSE; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C FOS; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SENESCENCE;

EID: 0031027206     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.3.1224     Document Type: Article
Times cited : (90)

References (63)
  • 1
    • 0022607792 scopus 로고
    • Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts
    • Angel, P., A. Poting, U. Mallick, H. J. Rahmsdorf, M. Schorpp, and P. Herrlich. 1986. Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol. Cell. Biol. 6:1760-1766.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 1760-1766
    • Angel, P.1    Poting, A.2    Mallick, U.3    Rahmsdorf, H.J.4    Schorpp, M.5    Herrlich, P.6
  • 2
    • 0028364290 scopus 로고
    • Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging
    • Atadja, P. W., K. Stringer, and K. T. Riabowol. 1994. Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging. Mol. Cell. Biol. 14:4991-4999.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4991-4999
    • Atadja, P.W.1    Stringer, K.2    Riabowol, K.T.3
  • 3
    • 0026324655 scopus 로고
    • Change in fibronectin mRNA splicing with in vitro passage
    • Burke, E. M., and D. B. Danner. 1991. Change in fibronectin mRNA splicing with in vitro passage. Biochem. Biophys. Res. Commun. 178:620-624
    • (1991) Biochem. Biophys. Res. Commun. , vol.178 , pp. 620-624
    • Burke, E.M.1    Danner, D.B.2
  • 6
    • 0028361374 scopus 로고
    • Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
    • Dimri, G. P., E. Hara, and J. Campisi. 1994. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269: 16180-16186.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 7
    • 0027332123 scopus 로고
    • Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-cdk2 and cyclin D1-cdk2 complexes
    • Dulic, V., L. F. Drullinger, E. Lees, S. I. Reed, and G. H. Stein. 1993. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-cdk2 and cyclin D1-cdk2 complexes. Proc. Natl. Acad. Sci. USA 90:11034-11038.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11034-11038
    • Dulic, V.1    Drullinger, L.F.2    Lees, E.3    Reed, S.I.4    Stein, G.H.5
  • 10
    • 0024843805 scopus 로고
    • Identification of highly abundant cDNA isolated from senescent WI-38 cells
    • Giordano, T., and D. N. Foster. 1989. Identification of highly abundant cDNA isolated from senescent WI-38 cells. Exp. Cell Res. 185:399-406.
    • (1989) Exp. Cell Res. , vol.185 , pp. 399-406
    • Giordano, T.1    Foster, D.N.2
  • 11
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • Goldstein, S. 1990. Replicative senescence: the human fibroblast comes of age. Science 249:1129-1133.
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 13
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-458.
    • (1973) Virology , vol.52 , pp. 456-458
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 14
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1
    • Hara, E., H. Tsuri, S. Shinozaki, and K. Oda. 1991. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 179: 528-534.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsuri, H.2    Shinozaki, S.3    Oda, K.4
  • 15
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 16
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 17
    • 0028294621 scopus 로고
    • A gene involved in control of human cellular senescence on human chromosome 1q
    • Hensler, P. J., L. A. Annab, J. C. Barrett, and O. M. Pereira-Smith. 1994. A gene involved in control of human cellular senescence on human chromosome 1q. Mol. Cell. Biol. 14:2291-2297.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2291-2297
    • Hensler, P.J.1    Annab, L.A.2    Barrett, J.C.3    Pereira-Smith, O.M.4
  • 18
    • 0021749262 scopus 로고
    • Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma virus
    • Herbomel, P., B. Bourachot, and M. Yaniv. 1984. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma virus. Cell 39:653-662.
    • (1984) Cell , vol.39 , pp. 653-662
    • Herbomel, P.1    Bourachot, B.2    Yaniv, M.3
  • 19
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Herper, J. W., G. R. Adami, N. Wi, K. Keyomarsi, and S. J. Elledge. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Herper, J.W.1    Adami, G.R.2    Wi, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 21
    • 0028150977 scopus 로고
    • Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts
    • Imai, S., T. Fujino, S. Nishibayashi, T. Manabe, and T. Takano. 1994. Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Mol. Cell. Biol. 14:7182-7194.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7182-7194
    • Imai, S.1    Fujino, T.2    Nishibayashi, S.3    Manabe, T.4    Takano, T.5
  • 22
    • 0021770759 scopus 로고
    • Human fibronectin: Cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats
    • Kornblihtt, A. R., K. Vibe-Pedersen, and F. E. Baralle. 1984. Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats. Nucleic Acids Res. 12: 5853-5868.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 5853-5868
    • Kornblihtt, A.R.1    Vibe-Pedersen, K.2    Baralle, F.E.3
  • 23
    • 0025827242 scopus 로고
    • Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area
    • Kumazaki, T., R. S. Robetorye, S. C. Robetorye, and J. R. Smith. 1991. Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp. Cell Res. 195:13-19.
    • (1991) Exp. Cell Res. , vol.195 , pp. 13-19
    • Kumazaki, T.1    Robetorye, R.S.2    Robetorye, S.C.3    Smith, J.R.4
  • 24
    • 0027380279 scopus 로고
    • Why are human cells resistant to malignant cell transformation in vitro?
    • Kuroki, T., and N. Huh. 1993. Why are human cells resistant to malignant cell transformation in vitro? Jpn. J. Cancer Res. 84:1091-1100.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 1091-1100
    • Kuroki, T.1    Huh, N.2
  • 25
    • 0022549575 scopus 로고
    • Existence of high abundance actiproliferative mRNA's in senescent human diploid fibroblasts
    • Lumpkin, C. K., J. K. McClung, Jr., O. M. Pereira-Smith, and J. R. Smith. 1986. Existence of high abundance actiproliferative mRNA's in senescent human diploid fibroblasts. Science 232:393-395.
    • (1986) Science , vol.232 , pp. 393-395
    • Lumpkin, C.K.1    McClung Jr., J.K.2    Pereira-Smith, O.M.3    Smith, J.R.4
  • 27
    • 0026350741 scopus 로고
    • The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors
    • Magnuson, V. L., M. Young, D. G. Schattenberg, M. A. Mancini, D. Chen, B. Steffensen, and R. J. Klebe. 1991. The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors. J. Biol. Chem. 266:14654-14662.
    • (1991) J. Biol. Chem. , vol.266 , pp. 14654-14662
    • Magnuson, V.L.1    Young, M.2    Schattenberg, D.G.3    Mancini, M.A.4    Chen, D.5    Steffensen, B.6    Klebe, R.J.7
  • 29
    • 0025275224 scopus 로고
    • Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation
    • Matsui, M., M. Tokuhara, Y. Konuma, N. Nomura, and R. Ishizaki. 1990. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 5:249-255.
    • (1990) Oncogene , vol.5 , pp. 249-255
    • Matsui, M.1    Tokuhara, M.2    Konuma, Y.3    Nomura, N.4    Ishizaki, R.5
  • 30
    • 0024396320 scopus 로고
    • Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
    • Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371-378.
    • (1989) Science , vol.245 , pp. 371-378
    • Mitchell, P.J.1    Tjian, R.2
  • 31
    • 0024991898 scopus 로고
    • pEF-BOS, a powerful mammalian expression vector
    • Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 5322
    • Mizushima, S.1    Nagata, S.2
  • 32
    • 0025866760 scopus 로고
    • Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence
    • Murano, S., R. Thweatt, R. J. Shmookler Reis, R. A. Jones, E. J. Moerman, and S. Goldstein. 1991. Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence. Mol. Cell. Biol. 11:3905-3914.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3905-3914
    • Murano, S.1    Thweatt, R.2    Shmookler Reis, R.J.3    Jones, R.A.4    Moerman, E.J.5    Goldstein, S.6
  • 33
    • 0022400622 scopus 로고
    • Neoplastic transformation of human diploid fibroblasts (KMS-6) by treatment with cobalt-60 gamma-rays
    • Namba, M., K. Nishitani, F. Hyodoh, F. Fukushima, and T. Kimoto. 1985. Neoplastic transformation of human diploid fibroblasts (KMS-6) by treatment with cobalt-60 gamma-rays. Int. J. Cancer 35:275-280.
    • (1985) Int. J. Cancer , vol.35 , pp. 275-280
    • Namba, M.1    Nishitani, K.2    Hyodoh, F.3    Fukushima, F.4    Kimoto, T.5
  • 34
    • 0023811519 scopus 로고
    • Multistep carcinogenesis of normal human fibroblasts: Human fibroblasts immortalized by repeated treatment with cobalt-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogene
    • Namba, M., K. Nishitani, F. Fukushima, and T. Kimoto. 1988. Multistep carcinogenesis of normal human fibroblasts: human fibroblasts immortalized by repeated treatment with cobalt-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogene. Anticancer Res. 8:947-958.
    • (1988) Anticancer Res. , vol.8 , pp. 947-958
    • Namba, M.1    Nishitani, K.2    Fukushima, F.3    Kimoto, T.4
  • 35
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. 1992. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 36
    • 0025953702 scopus 로고
    • Genetic analysis of indefinite division in human cells: Evidence for a cell senescence-related gene(s) on human chromosome 4
    • Ning, Y., J. L. Weder, A. M. Killary, D. H. Ledbetter, J. R. Smith, and O. M. Pereira-Smilh. 1991. Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc. Natl. Acad. Sci. USA 88:5635-5639.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5635-5639
    • Ning, Y.1    Weder, J.L.2    Killary, A.M.3    Ledbetter, D.H.4    Smith, J.R.5    Pereira-Smilh, O.M.6
  • 37
    • 0023125528 scopus 로고
    • Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells
    • Nishikura, K., and J. K. Murray. 1987. Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells. Mol. Cell. Biol. 7:639-649.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 639-649
    • Nishikura, K.1    Murray, J.K.2
  • 38
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screening
    • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screening. Exp. Cell Res. 211:90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 40
    • 0345693050 scopus 로고
    • Cloning and sequence of a cDNA coding for the human b-migrating endothelial-cell-type plasminogen activator
    • Ny, T., M. Sawdey, D. Lawrence, J. L. Millan, and D. J. Loskutoff. 1986. Cloning and sequence of a cDNA coding for the human b-migrating endothelial-cell-type plasminogen activator. Proc. Natl. Acad. Sci. USA 83:6776-6780.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6776-6780
    • Ny, T.1    Sawdey, M.2    Lawrence, D.3    Millan, J.L.4    Loskutoff, D.J.5
  • 41
    • 0027382325 scopus 로고
    • Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1
    • Ogata, T., D. Ayusawa, M. Namba, E. Takahashi, M. Oshimura, and M. Oishi. 1993. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol. Cell. Biol. 13:6036-6043.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6036-6043
    • Ogata, T.1    Ayusawa, D.2    Namba, M.3    Takahashi, E.4    Oshimura, M.5    Oishi, M.6
  • 42
    • 0020610446 scopus 로고
    • Evidence for the recessive nature of cellular immortality
    • Pereira-Smith, O. M., and J. R. Smith. 1983. Evidence for the recessive nature of cellular immortality. Science 221:964-966.
    • (1983) Science , vol.221 , pp. 964-966
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 43
    • 0011208723 scopus 로고
    • Genetic analysis of indefinite division in human cells: Identification of four complementation groups
    • Pereira-Smith, O. M., and J. R. Smith. 1988. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. USA 85:6042-6046.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6042-6046
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 44
    • 0001111837 scopus 로고
    • Expression of cell cycle-dependent genes in young and senescent WI38 fibroblasts
    • Rittling, S. R., K. M. Brooks, V. J. Cristofalo, and R. Baserga. 1986. Expression of cell cycle-dependent genes in young and senescent WI38 fibroblasts Proc. Natl. Acad. Sci. USA 83:3316-3320.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3316-3320
    • Rittling, S.R.1    Brooks, K.M.2    Cristofalo, V.J.3    Baserga, R.4
  • 45
    • 0026758356 scopus 로고
    • The growth arrest-specific gene, gas 1, is involved in growth suppression
    • Sal, G. D., M. E. Ruaro, L. Philipson, and C. Schneider. 1992. The growth arrest-specific gene, gas 1, is involved in growth suppression. Cell 70:595-607.
    • (1992) Cell , vol.70 , pp. 595-607
    • Sal, G.D.1    Ruaro, M.E.2    Philipson, L.3    Schneider, C.4
  • 47
    • 0028060189 scopus 로고
    • The LIM domain: A new structural motif found in zinc-finger-like proteins
    • Sanchez-Garcia, I., and T. H. Rabbitts. 1994. The LIM domain: a new structural motif found in zinc-finger-like proteins. Trends Genet. 10:315-320.
    • (1994) Trends Genet. , vol.10 , pp. 315-320
    • Sanchez-Garcia, I.1    Rabbitts, T.H.2
  • 50
    • 0028134697 scopus 로고
    • The LIM domain is a modular protein-binding interface
    • Schmeichel, K. L., and M. C. Beckerle. 1994. The LIM domain is a modular protein-binding interface. Cell 79:211-219.
    • (1994) Cell , vol.79 , pp. 211-219
    • Schmeichel, K.L.1    Beckerle, M.C.2
  • 51
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • Seshadri, T., and J. Campisi. 1990. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247:205-209.
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 52
    • 0023105530 scopus 로고
    • Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport
    • Shibanuma, M., T. Kuroki, and K. Nose. 1987. Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport. Eur. J. Biochem. 164:15-19.
    • (1987) Eur. J. Biochem. , vol.164 , pp. 15-19
    • Shibanuma, M.1    Kuroki, T.2    Nose, K.3
  • 53
    • 0028171070 scopus 로고
    • Characterization of the TGFβ1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence
    • Shibanuma, M., J. Mashimo, T. Kuroki, and K. Nose. 1994. Characterization of the TGFβ1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. J. Biol. Chem. 269:26767-26774.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26767-26774
    • Shibanuma, M.1    Mashimo, J.2    Kuroki, T.3    Nose, K.4
  • 54
    • 0024541932 scopus 로고
    • Regulation of collagenase and collagenase mRNA production in early- and late-passage human diploid fibroblasts
    • Sottile, J., D. M. Mann, V. Diemer, and A. J. T. Millis. 1989. Regulation of collagenase and collagenase mRNA production in early- and late-passage human diploid fibroblasts. J. Cell. Physiol. 138:281-290.
    • (1989) J. Cell. Physiol. , vol.138 , pp. 281-290
    • Sottile, J.1    Mann, D.M.2    Diemer, V.3    Millis, A.J.T.4
  • 55
    • 0006312841 scopus 로고
    • Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene
    • Stampfer, M. R., and J. C. Hartley. 1985. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc. Natl. Acad. Sci. USA 82:2394-2398.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2394-2398
    • Stampfer, M.R.1    Hartley, J.C.2
  • 56
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein, G. H., M. Beeson, and L. Gordon. 1990. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249: 666-668.
    • (1990) Science , vol.249 , pp. 666-668
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 58
    • 0025020081 scopus 로고
    • Induction of cellular senescence in immortalized cells by human chromosome 1
    • Sugawara, O., M. Oshimura, M. Koi, L. A. Annab, and J. C. Barrett. 1990. Induction of cellular senescence in immortalized cells by human chromosome 1. Science 247:707-710.
    • (1990) Science , vol.247 , pp. 707-710
    • Sugawara, O.1    Oshimura, M.2    Koi, M.3    Annab, L.A.4    Barrett, J.C.5
  • 59
    • 0023609911 scopus 로고
    • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin
    • Wang, E. 1987. Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. J. Cell. Physiol. 133:151-157.
    • (1987) J. Cell. Physiol. , vol.133 , pp. 151-157
    • Wang, E.1
  • 60
    • 0024445960 scopus 로고
    • Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
    • West, M. D., O. M. Pereira-Smith, and J. R. Smith. 1989. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp. Cell Res. 184:138-147.
    • (1989) Exp. Cell Res. , vol.184 , pp. 138-147
    • West, M.D.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 61
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
    • Wright, W. E., O. M. Pereira-Smith, and J. F. Shay. 1989. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol. 9:3093-3096.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3093-3096
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.F.3
  • 62
    • 0026682717 scopus 로고
    • Telomere positional effects and the regulation of cellular senescence
    • Wright, W. E., and J. W. Shay. 1992. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 8:193-197.
    • (1992) Trends Genet. , vol.8 , pp. 193-197
    • Wright, W.E.1    Shay, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.