Associations of candidate loci angiotensinogen and angiotensin- converting enzyme with severe hypertension: The NHLBI Family Heart Study

Annals of Epidemiology

Volumn 7, Issue 1, 1997, Pages 13-21

  Borecki, I B ^a   Province, M A ^a   Ludwig, E H ^b   Ellison, R C ^c   Folsom, A R ^d   Heiss, G ^e   Lalouel, J M ^b   Higgins, M ^f   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e IL   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

angiotensin converting enzyme; Angiotensinogen; Blacks; case control study; Caucasians; epistasis; genotypes; hypertension

Indexed keywords

ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0031026596     PISSN: 10472797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-2797(97)00155-5     Document Type: Article

References (26)

1. 1. MacMahon S, Peto R, Cutler J, et al., Blood pressure, stroke and coronary heart disease; Part 1, prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias. Lancet. 1990;335:765-74.
2. 2. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, diagnosis, and management. New York: Raven Press; 1990:81-100.
3. 3. MacGregor GA, Markandu ND, Roulston JE, Jones JC, Morton JJ. Maintenance of blood pressure by the renin-angiotensin system in normal man. Nature. 1981;291:329-331.
4. 4. Williams RR, Hunt SC, Hopkins PN, Hasstedt SJ, Wu LL, Lalouel JM. Tabulations and expectations regarding the genetics of human hypertension. Kidney Int. 1994;44(Suppl)S57-S64).
5. 5. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al. Molecular basis of human hypertension: Role of angiotensinogen. Cell 1992;71:169-180.
6. 6. Cambien F, Poirer O, Lecerf L. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641-644.
7. 7. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel JM. Absence of linkage between the angiotensin converting enzyme and human essential hypertension. Nature Genet. 1992;1:72-75.
8. 8. Higgins M, Province M, Heiss G, et al. The NHLBI Family Heart Study: Objectives and design. Am J Epidemiol., 1996; 143:1219-1228.
9. 9. Ludwig EH, Borecki IB, Ellison RC, et al. Associations of candidate loci angiotensin-converting enzyme and angiotensinogen with coronary heart disease and myocardial infarction: The Family Heart Study. 1996; Ann Epidemiol. 1996; in press.
10. 10. The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: Design and objectives. Am J Epidemiol. 1989;129: 687-702.
11. 11. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acid Res. 1992;20:1433.
12. 12. Hata A, Manikawa C, Sasaki M, Sato K, Nakamura T, Tamura K. Angiotensinogen as a risk factor for essential hypertension in Japan. J Clin Invest. 1994;93:1285-1287.
13. 235 → THR variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun. 1993;197:833-839.
14. 14. Caulfield M, Lavender P, Farrall M, et al. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med. 1994;330:1629-1633.
15. 15. Rotimi C, Morrison L, Cooper R, et al. Antiogensinogen gene in human hypertension: Lack of an association of the 235T allele among African Americans. Hypertension. 1994;24:591-594.
16. 16. Morise T, Takeuchi Y, Takeda R. Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension. J Int Med. 1995;237:175-180.
17. 17. Tiret L, Ricard S, Poirer O, et al. Genetic variation at the angiotensinogen locus in relation to high blood pressure and myocardial infarction: The ECTIM study. J Hypertension. 1995;13:311-317.
18. 18. Ramachandran VS, Levy D, Larson MC, et al. Association of a molecular variant of the angiotensinogen gene and hypertension. J Am Coll Cardiol. 1995;25, Suppl. A:24A.
19. 19. Zee RYL, Lou U, Griffiths LR, Morris BJ. Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun. 1992;184:9-15.
20. 20. Morris BJ, Zee RYL, Schrader AP. Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest. 1994;94:1085-1089.
21. 235→ Thr polymorphism in a London normotensive and hypertensive black and white population. J Hum Hypertens. 1994;8:639-640.
22. 22. Rutledge DR, Browe CS, Kubilis PS, Ross EA. Analysis of two variants of the angiotensinogen gene in essential hypertensive African-Americans. Am J Hypertens. 1994;7(7 pt1):651-654.
23. 23. Bloem LJ, Manatunga AK, Tewksbury DA, Pratt JH. The serum angiotensinogen concentration and variants fo the angiotensinogen gene in white and black children. J Clin Invest. 1995;95:948-953.
24. 24. Ward K, Hata A, Jeunemaitte X, et al. A molecular variant of angiotensinogen associated with preeclampsia. Nature Genetics. 1993;4:59-61.
25. 25. Arngrímsson R, Purandare SM, Connor M, et al. Angiotensinogen: A candidate gene involved in preeclampsia? Nature Genetics. 1993;4:114-115.
26. 26. Kim HS, Krege JH, Kluckman KD, et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA. 1995;92:2735-2739.