Human autoimmune anti-proteinase 3 scFv from a phage display library

Clinical and Experimental Immunology

Volumn 107, Issue 2, 1997, Pages 269-281

  Finnern, R ^a,g   Pedrollo, E ^a   Fisch, I ^b   Wieslander, J ^c   Marks, J D ^d   Lockwood, C M ^e   Ouwehand, W H ^a,f  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c Wieslab AB   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^g UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

autoimmunity; human V gene phage display libraries; proteinase 3; scFv antibody fragment

Indexed keywords

AUTOANTIGEN; IMMUNOGLOBULIN G; PROTEINASE;

ADULT; ARTICLE; AUTOIMMUNITY; CASE REPORT; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; ETIOLOGY; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MALE; MUTATION; PHAGE DISPLAY; PRIORITY JOURNAL; WEGENER GRANULOMATOSIS;

EID: 0031026403     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1997.254-ce1127.x     Document Type: Article

References (37)

1. Plotz PH. The role of autoantigens in the induction and maintenance of autoimmunity. Mol Biol Rep 1992; 16:127-32.
2. Horsfall AC. Molecular mimicry and autoantigens in connective tissue diseases. Mol Biol Rep 1992; 16:139-47.
3. Baixeras E, Bosca L, Stauber C, Gonzalea A, Carrera AC, Gonzalo JA, Martinez C. From apoptosis to autoimmunity: insights from the signaling pathways leading to proliferation or to programmed cell death. Immunol Rev 1994; 142:53-91.
4. Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983; 98:76.
5. Ludemann J, Gross WL. Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis. Clin Exp Immunol 1987; 69:350-7.
6. Noelle B, Specks U, Luedemann J, Rohrbach MS, DeRemee RA, Gross WL. Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener's granulomatosis. Ann Int Med 1989; 111:28-40.
7. van der Woude FJ, Rasmussen N, Lobatto S, Wük A, Permin H, van Es LA, van der Giessen M, van der Hem GK. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985; 1:425-9.
8. Falk RJ, Jennette JC. Wegener's granulomatosis, systemic vasculitis, and antineutrophil cytoplasmic autoantibodies. Annu Rev Med 1991; 42:459-69.
9. Gross WL, Schmitt WH, Csernok E. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 1993; 91:1-12.
10. van der Woude FJ. Review: The current status of neutrophil cytoplasmic antibodies. Clin Exp Immunol 1989; 78:143.
11. Csernok E, Ernst M, Schmitt W, Bainton DF, Gross WL. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clin Exp Immunol 1994; 95:244-50.
12. Gross WL. New developments in the treatment of systemic vasculitis. Curr Opin Rheumatol 1994; 6:11-19.
13. Winter G, Milstein C. Man-made antibodies. Nature 1991; 349:293-9.
14. James K, Bell GT. Human monoclonal antibody production: current status and future prospects. J Immunol Methods 1987: 100:5-40.
15. Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989; 246:1275-81.
16. McCafferty J, Griffiths AD, Winter G, Chiswell DJ. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 1990; 348:552-4.
17. Marks JD, Hoogenboom HR, Griffith AD, Winter G. Molecular evolution of proteins on filamentous phage: mimicking the strategy of the immune system. J Biol Chem 1992; 267:16007-10.
18. Hoogenboom HR, Winter G. By-passing immunization - human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. J Mol Biol 1992; 227:381-8.
19. Marks JD, Ouwehand WH, Bye JM et al. Human antibody fragments specific for human blood group antigens from a phage display library. Bio/Technol 1993; 11:1145-9.
20. Nissim A, Hoogenboom HR, Tomlinson IM, Flynn G, Midgley C, Lane D, Winter G. Antibody fragments from a 'single pot' phage display library as immunochemical reagents. EMBO J 1994; 13:692-8.
21. Griffiths AD, Malmqvist M, Marks JD et al. Human anti-self antibodies with high specificity from phage display libraries. EMBO J 1993; 12:725-34.
22. Finnern R, Bye JM, Dolman KM, Zhao M-M, Short A, Marks JD, Lockwood MC, Ouwehand WH. Molecular characteristics of antiself antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries. Clin Exp Immunol 1995; 102:566-74.
23. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press. 1989.
24. Dower WJ, Miller JF, Ragsdale CW. High efficiency transformation of E. coli by high voltage electroporation. Nucl Acids Res 1988; 16:6127-45.
25. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffith AD, Winter G. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J Mol Biol 1991; 222:581-97.
26. Griffiths AD, Williams SC, Hartley O et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 1994; 13:3245-60.
27. Ward S, Guessow D, Griffiths AD, Jones PT, Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 1989; 341:544-6.
28. Hochuli E. Aufarbeitung von Bioproteinen: Elegant und wirtschaftlich. Chemische Industrie 1989; 12:69-70.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
30. Baslund B, Segelmark M, Wiik A, Szpirt W, Petersen J, Wieslander J. Screening for anti-neutrophil cytoplasmic antibodies (ANCA): is indirect immunofluorescence the method of choice? Clin Exp Immunol 1995; 99:486-92.
31. Clackson T, Hoogenboom HR, Griffiths AD, Winter G. Making antibody fragments using phage display libraries. Nature 1991; 352:624-8.
32. Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 1992; 227:776-98.
33. Cox JPL, Tomlinson IM, Winter G. A directory of human germline Vκ segments reveals a strong bias in their usage. Eur J Immunol 1994; 24:827-36.
34. Williams SC, Winter G. Cloning and sequencing of human immunoglobulin Vλ gene segments. Eur J Immunol 1993; 23:1456-61.
35. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995; 16:237-42.
36. de Wildt RM, Finnern R, Ouwehand WH, Griffiths AD, van Venrooij WJ, Hoet RM. Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and patient-derived combinatorial V gene library. Eur J Immunol 1996; 26:629-39.
37. Chazenbalk GD, Portolano S, Russo D, Hutchison JS, Rapoport B, McLachlan S. Human organ-specific autoimmune disease. J Clin Invest 1993; 92:62-74.