Familial spastic paraparesis: Evaluation of locus heterogeneity, anticipation, and haplotype mapping of the SPG4 locus on the short arm of chromosome 2

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 74, Issue 1, 1997, Pages 26-36

  Bird, Thomas D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

familial spastic paraplegia; genetic heterogeneity; genetic linkage analysis

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CHILD; CHROMOSOME 2P; FEMALE; GENE LOCATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATHOGENESIS; PEDIGREE ANALYSIS; POINT MUTATION; PRIORITY JOURNAL;

AGE OF ONSET; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 2; FEMALE; GENETIC MARKERS; HAPLOTYPES; HUMANS; LINKAGE (GENETICS); MALE; PEDIGREE; RECOMBINATION, GENETIC; SPASTIC PARAPLEGIA, HEREDITARY;

EID: 0031025555     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19970221)74:1<26::AID-AJMG7>3.0.CO;2-T     Document Type: Article

References (4)

1. Behan WMH, Maia M (1974): Strumpell's familial spastic paraplegia: genetics and neuropathology. J Neurol Neurosurg Psychiat 37:8-20.
2. Cambi F, Tang X-M, Cordray MS, Fain PR, Keppen LD, Barker DF (1996): Refined genetic mapping and proteolipid protein mutation analysis in X-linked pure hereditary spastic paraplegia. Neurol 46:1112-1117.
3. Kenwrick SV, Ionasescu G, Ionasescu C, Searby A, King M, Dubowitz M, Davies KE (1986): Linkage studies of X-linked recessive spastic paraplegia using DNA probes. Hum Genet 73:264-266.
4. Lathrop GM, Lalouel JM, Ott J (1984): Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81:3443-3446.