Kynurenic acid and kynurenine aminotransferase in heart

Pediatric Research

Volumn 41, Issue 3, 1997, Pages 404-410

  Baran, Halina ^a,b   Amann, Gabriele ^a   Lubec, Barbara ^a   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 2 OXOISOCAPROIC ACID; ADENOSINE PHOSPHATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; EXCITATORY AMINO ACID RECEPTOR; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; N METHYL DEXTRO ASPARTIC ACID; PYRUVIC ACID;

ARTICLE; AUTOPSY; BRAIN HEMORRHAGE; CAUSE OF DEATH; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HEART FUNCTION; HEART MUSCLE POTENTIAL; HEMORRHAGIC SHOCK; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; NEWBORN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEPTICEMIA; STATISTICAL ANALYSIS; TRANSAMINATION; TRISOMY 21; TRYPTOPHAN METABOLISM;

EID: 0031025237     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199703000-00017     Document Type: Article

References (38)

1. 6 and steroid hormone. Am J Clin Nutr 24:243-247
2. Stone TW 1993 Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45:309-379
3. Noguchi T, Minatogawa Y, Okuno E, Nakatani M, Morimoto M, Kido R 1975 Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. Biochem J 151:399-406
4. Okuno E, Minatogawa Y, Nakamura M, Kamoda N, Nakanishi J, Makino M, Kido R 1980 Crystallization and characterization of human liver kynurenine-glyoxylate aminotransferase. Biochem J 189:581-590
5. Okuno E, Schmidt W, Parks DA, Nakamura M, Schwarcz R 1991 Measurement of rat brain kynurenine aminotransferase at physiological kynurenine concentrations. J Neurochem 57:533-540
6. Baran H, Schwarcz R 1993 Regional differences in the ontogenetic pattern of kynurenine aminotransferase in the rat brain. Dev Brain Res 74:283-286
7. Okuno E, Nakamura M, Schwarcz R 1991 Two kynurenine aminotransferases in human brain. Brain Res 542:307-312
8. 3H]kynurenine as a substrate Neuroscience 55:177-184
9. Baran H, Okuno E, Kido R, Schwarcz R 1994 Purification and characterization of kynurenine aminotransferase I from human brain. J Neurochem 62:730-738
10. Schwarcz R, Price DL 1991 The role of excitotoxins in experimental systems and in human neurological disorders. In: Price DL, Thoenen H, Aguayo AJ (eds) Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. John Wiley & Sons Ltd, Chichester, UK, pp 21-34
11. Watkins JC, Krogsgaard-Larsen P, Honore T 1990 Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci 11:26-33
12. Choi DW 1988 Glutamate neurotoxicity and diseases of the nervous system Neuron 1:623-634
13. Andine P, Lehmann A, Ellren K, Wennberg E, Kjellmer I, Nielsen T, Hagberg H 1988 The excitatory amino acid antagonist kynurenic acid administered after hypoxic ischemia in neonatal rats offers neuroprotection. Neurosci Lett 90:208-212
14. Perkins MN, Stone TW 1982 An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247:184-187
15. Beninger RJ, Jhamandas K, Boeghman RJ, El-Defrawy SR 1986 Kynurenic acid-induced protection of neurochemical and behavioural deficits produced by quinolinic acid injections into the nucleus basalis of rats. Neurosci Lett 68:317-321
16. Foster AC, Vezzani A, French ED, Schwarcz R 1984 Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neurosci Lett 48:273-278
17. Schwarcz R 1992 Excitotoxins, kynurenines and neuropsychiatrie diseases: Implications for drug development. In: Schousboe A, Diemer NH, Kofod H (eds) Drug Research Related to Neuroactive Amino Acids (Alfred Benzon Symposium 32). Munksgaard, Copenhagen, pp 287-301
18. Jauch D, Urbanska EM, Guidetti P, Bird ED, Vonsattel J-PG, Whetsell WO Jr, Schwarcz R 1995 Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases. J Neurol Sci 130:39-47
19. Beal MF, Maison WR, Storey E, Milbury P, Ryan EA, Ogawa T, Bird ED 1992 Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. J Neurol Sci 108:80-87
20. Feldblum S, Rougier A, Loiseau H, Loiseau P, Cohadon F, Morselli PL, Lloyd KG 1988 Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue. Epilepsia 29:523-529
21. Carla V, Lombardi G, Beni M, Russi P, Moneti G, Moroni F 1988 Identification and measurement of kynurenic acid in the rat brain and other organs. Anal Biochem 169:89-94
22. Mosca M, Cozzi L, Breton J, Speciale C, Okuno E, Schwarcz R, Benatti L 1994 Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. FEBS Lett 353:21-24
23. Lorenzo PS, Butta NV, Adler-Graschinsky E 1994 Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria. Eur J Pharmacol 258:253-260
24. Abrahams TP, Taveira DaSilva AM, Hamosh P, McManigle JE, Gillis RA 1993 Cardiorespiratory effects produced by blockade of excitatory amino acid receptors in cats. Eur J Pharmacol 238:223-233
25. Turski WA, Nakamura M, Todd WP, Carpenter BK, Whetsell WO Jr. Schwarcz R 1988 Identification and quantification of kynurenic acid in human brain tissue. Brain Res 454:164-169
26. Shibata K 1988 Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography. J Chromatogr 430:376-380
27. Swartz KJ, Maison WR, MacGarvey U, Ryan EA, Beal MF 1990 Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection. Anal Biochem 185:363-376
28. Bradford M 1976 A rapid and sensitive method for the quantitation of microgram-quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72:248-254
29. Halperin JJ, Heyes MP 1992 Neuroactive kynurenines in Lyme borreliosis. Neurology 42:43-50
30. Speciale C, Schwarcz R 1990 Uptake of kynurenine into rat brain slices J Neurochem 54:156-163
31. Heyes MP, Saito K, Devinsky O, Nadi NS 1994 Kynurenine pathway metabolites in cerebrospinal fluid and serum in complex partial seizures. Epilepsia 35:251-259
32. Taylor J, Robinson BH, Sherwood WG 1978 A defect in branched-chain amino acids metabolism in a patient with congenital lactic acidosis due to dihydrolipoyl dehydrogenase deficiency. Pediatr Res 12:60-62
33. Robinson BH, Taylor J, Sherwood WG 1977 Deficiency of dihydrolipoyl dehydrogenase (a component of the pyruvate and α-ketoglutarate dehydrogenase complex): A cause of congenital chronic lactic acidosis in infancy. Pediatr Res 11:1198-1206
34. Haworth JC, Perry TL, Blass JP, Hansen S, Urquhart N 1976 Lactic acidosis in three, sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydro genase complexes. Pediatrics 58:564-751
35. Kessler M, Terramani T, Lynch G, Baudry M 1989 A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 52:1319-1328
36. Baran H, Gramer M, Hönack D, Löscher W 1995 Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats. Eur J Pharmacol 286:167-175
37. Baran H, Cairns N, Singewald N, Lubec G 1995 Kynurenic acid and kynurenine aminotransferases KAT I and KAT II in the brains of patients with DOWN syndrome and Alzheimer's disease. Soc Neurosci Abstr 21:581.5
38. Baran H, Cairns N, Lubec B, Lubec G 1996 Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome. Life Sci 58:1891-1899