Alveolar fluid glutathione is not reduced in asymptomatic HIV- seropositive subjects

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 1, 1997, Pages 374-377

  Pacht, Eric R ^a,b   Diaz, Phil ^a   Clanton, Tom ^a   Hart, Judy ^a   Gadek, James E ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b N 325 Means Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION TEST; LUNG LAVAGE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0031024988     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.1.9001339     Document Type: Article

References (29)

1. Kosower, N. S., and E. M. Kosower. 1978. The glutathione status of cells. Int. Rev. Cytol. 54:109-160.
2. Meister, A., and M. E. Anderson. 1983. Glutathione. Ann. Rev. Biochem. 52:711-760.
3. Jenkinson, S. G., R. D. Black, and R. A. Lawrence. 1988. Glutathione concentrations in rat lung bronchoalveolar lavage fluid: effects of hyperoxia. J. Lab. Clin. Med. 112:345-351.
4. Sagone, A. L., R. M. Husney, M. S. O'dorisio, and E. N. Metz. 1984. Mechanisms for the oxidation of reduced glutathione by stimulated granulocytes. Blood 63:96-104.
5. Buhl, R., K. J. Holroyd, A. M. Cantin, H. A. Jaffe, F. B. Wells, C. Saltini, and R. G. Crystal. 1989. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 2:1294-1298.
6. Hamilos, D. L., and H. J. Wedner. 1985. The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation. J. Immunol. 135:2740-2747.
7. Droege, W., C. Pottmeyer-Gerber, H. Schmidt, and S. Nick. 1986. Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172:151-156.
8. Hunninghake, G. W., J. E. Gadek, O. Kawanami, V. J. Ferrans, and R. G. Crystal. 1979. Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am. J. Pathol. 97:149-206.
9. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin, and R. G. Crystal. 1986. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol. 60:532-538.
10. Sies, H., and T. P. M. Akerboom. 1984. Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol. 105:445-451.
11. Eck, H. P., H. Gmunder, M. Hartmann, D. Petzoldt, V. Daniel, and W. Droge. 1989. Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients. Biol. Chem. Hoppe-Seyler. 370:101-108.
12. Staal, F. J. T., S. W. Ela, M. Roederer, M. T. Anderson, L. A. Herzenberg, and L. A. Herzenberg. 1992. Glutathione deficiency and human immunodeficiency virus infection. Lancet 339:909-912.
13. Staal, F. J. T., M. Roederer, D. M. Israelski, J. Bubp, L. A. Mole, D. McShane, S. C. Deresinski, W. Ross, H. Sussman, P. A. Raju, M. T. Anderson, W. Moore, S. W. Ela, L. A. Herzenberg, and L. A. Herzenberg. 1992. Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals. AIDS Res. Hum. Retroviruses 8:305-311.
14. Roederer, M., F. J. T. Staal, H. Osada, L. A. Herzenberg, and L. A. Herzenberg. 1991. CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Intl. Immunol. 3:933-937.
15. Barbarini, G., C. Filice, D. Zanaboni, G. Garavelli, A. Malfitano, E. Brunetti, and G. Bellomo. 1994. Glutathione deficiency in the liver of HIV seropositive subjects (abstract). Int. Conf. AIDS 10:20.
16. Delatour, F., M. H. Prevot, C. Marquetty, and M. Gougerot-Pocidalo. 1992. Total glutathione concentration in plasma of infected patients and HIV disease progression (abstract). Int. Conf. AIDS 8:72.
17. Pacht, E., P. Diaz, T. Clanton, J. Hart, and J. Gadek. 1996. Longitudinal decrease in epithelial lining fluid (ELF) glutathione (GSH) in asymptomatic HIV-seropositive (HIV+) subjects (abstract). Am. J. Respir. Crit. Care Med. 153:A811.
18. Robinson, M. K., R. W. Hong, and D. W. Wilmore. 1992. Glutathione deficiency and HIV infection. Lancet 339:1603-1604.
19. Martensson, J. 1986. The effect of fasting on leukocyte and plasma glutathione and sulfur amino acid concentrations. Metabolism 35: 118-121.
20. Bunnell, E., and E. Pacht. 1993. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 148:1174-1178.
21. Buhl, R. 1994. Imbalance between oxidants and antioxidants in the lungs of HIV-seropositive individuals. Chem.-Biol. Interact. 91:147-158.
22. Abernathy, F., and E. Pacht. 1995. Alteration of adenosine triphosphate and other nucleotides after sublethal oxidant injury to rat type II alveolar epithelial cells. Am. J. Med. Sci. 309:140-145.
23. Pacht, E., and F. Abernathy. 1995. Prevention of intracellular adenosine triphosphate depletion after sublethal oxidant injury to rat type II alveolar epithelial cells with exogenous glutathione and N-acetylcysteine. Am. J. Med. Sci. 310:133-137.
24. Chang, M., M. Shi, and H. J. Forman. 1992. Exogenous glutathione protects endothelial cells from menedione toxicity. Am. J. Physiol. 262: L637-L643.
25. Forman, H. J., and D. Skelton. 1989. Extracellular glutathione protects alveolar macrophages from hyperoxic injury: possible role of gamma-glutamyl transpeptidase (abstract). Am. Rev. Respir. Dis. 139:A44.
26. Staal, F. J. T., M . Roederer, P. A. Raju, M. T. Anderson, S. W. Ela, L. A. Herzenberg, and L. A. Herzenberg. 1993. Antioxidants inhibit stimulation of HIV transcription. AIDS Res. Hum. Retroviruses 9: 299-306.
27. Buhl, R, H. A. Jaffe, K. J. Holroyd, F. B. Wells, A. Mastrangeli, C. Saltini, A. M. Cantin, and R. G. Crystal. 1990. Glutathione deficiency and HIV. Lancet 335:546.
28. Holroyd, K. J., R. Buhl, Z. Borok, J. H. Roum, A. D. Bokser, G. J. Grimes, D. Czerski, A. M. Cantin, and R. G. Crystal. 1993. Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment. Thorax 48:985-989.
29. Nottet, H. S. L. M., B. S. van Asbeck, L. De Graaf, N. M. de Vos, M. R. Visser, and J. Verhoef. 1994. Role for oxygen radicals in self-sustained HIV-1 replication in monocyte-derived macrophages: enhanced HIV-1 replication by N acetyl-L-cysteine. J. Leuk. Biol. 56: 702-707.