Endothelin-receptor antagonist FR 139317 reduces infarct size in a rabbit model when given before, but not after, coronary artery occlusion

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 1, 1997, Pages 87-92

  Burke, Sandra E ^a   Nelson, Richard A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Endothelin; ET(A) receptor antagonism; Infarct size; Myocardial infarction; Reperfusion injury

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; HEART INFARCTION SIZE; HEART PROTECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; AZEPINES; DISEASE MODELS, ANIMAL; ENDOTHELINS; HEART; INDOLES; MALE; MYOCARDIAL INFARCTION; RABBITS; RECEPTORS, ENDOTHELIN; TIME FACTORS;

EID: 0031024474     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199701000-00014     Document Type: Article

References (38)

1. Shigeno T, Mima T, Yanagisawa M, et al. Possible role of endothelin in the pathogenesis of cerebral vasospasm. J Cardiovasc Pharmacol 1991;17(suppl 7):S480-3.
2. Toyo-oka T, Aizawa T, Suzuki N, et al. Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. Circulation 1991;83:476-83.
3. Ohlstein EH, Douglas SA. Endothelin-1 modulates vascular smooth muscle structure and vasomotion: implications in cardiovascular pharmacology. Drug Dev Res 1993;29:108-28.
4. Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC. Increased endothelin in experimental heart failure. Circulation 1990;82:2226-30.
5. Yasuda M, Kohno M, Tahara A, et al. Circulating immunoreactive endothelin in ischemic heart disease. Am Heart J 1990;119:801-6.
6. Miyauchi T, Yanagisawa M, Tomizawa T, et al. Increased plasma concentration of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet 1989;2:53-4.
7. Salminen K, Tikkanen I, Saijonmaa O, Nieminen M, Fyhrquist F, Frick MH.[Letter]. Lancet 1989;2:747.
8. A receptor antagonist reduces myocardial infarction induced by coronary artery occlusion and reperfusion in the rat. Pharmacology 1994;49:319-24.
9. A receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion. Br J Pharmacol 1994;112:75-80.
10. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Circ Res 1991;69:370-7.
11. 125I]ET-1 binding to the atherosclerotic human coronary artery. Br J Pharmacol 1994;112:386-9.
12. B receptors mediate vascular smooth-muscle contraction. J Cardiovasc Pharmacol 1993;22(suppl 8): S144-8.
13. Suzuki T, Hiroyoshi H, Mitsui Y. Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium. FEBS Lett 1990;268:149-51.
14. Takanashi M, Endoh M. Characterization of positive inotropic effect of endothelin on mammalian ventricular myocardium. Am J Physiol 1991;261:H611-9.
15. A receptor antagonist. JPET 1993;264:1040-6.
16. B receptor. Br J Pharmacol 1993;109:530-4.
17. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5.
18. B-like receptors. Biochem Biophys Res Commun 1992;184:100-6.
19. B receptors coexist on rabbit pulmonary artery vascular smooth muscle mediating contraction. Biochem Biophys Res Commun 1993;196:209-15.
20. Eglen RM, Michel AD, Sharif NA, Swank SR, Whiting RL. The pharmacological properties of the peptide endothelin. Br J Pharmacol 1989;97:1297-307.
21. Ohlstein EH, Horohonich S, Hay DWP. Cellular mechanisms of endothelin in rabbit aorta. JPET 1989;250:548-55.
22. Donckier J, Hanet C, Stoleru L, et al. Effects of endothelin-1 at pathophysiologic concentrations on coronary perfusion and mechanical function of normal and postischemic myocardium. J Cardiovasc Pharmacol 1994;23:212-9.
23. Kusumoto K, Awane Y, Fujiwara S, Watanabe T. Role of endogenous endothelin in extension of rabbit myocardial infarction. J Cardiovasc Pharmacol 1993;22(suppl 8):S339-42.
24. Grover GJ, Sleph PG, Fox M, Trippodo NC. Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts. JPET 1992;263:1074-82.
25. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide. Pflugers Arch 1988;413:108-12.
26. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 1988;255:H970-3.
27. Jain P, Goligorsky M, Brown M, Horwitz J, Vlay SC. Do plasma endothelin levels during acute myocardial infarction correlate with infarct size? Clin Res 1992;40:402A.
28. Omland T, Lie RT, Aakvaag A, Aarsland T, Dickstein K. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation 1994;89:1573-9.
29. Maxwell MP, Hearse DJ, Yellon DM. Species variation in the coronary collateral circulation during regional myocardial ischemia: a critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 1987;21:737-46.
30. 125I]endothelin-1 binding to rat cardiac membranes. J Cardiovasc Pharmacol 1990; 15:436-43.
31. 125I]endothelin-1 binding sites in rat cardiac membrane fragments. J Cardiovasc Pharmacol 1989;13(suppl 5):S171-3.
32. Schini VB, Hendrickson H, Heublein DM, Burnett JC Jr, Vanhoutte PM. Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells. Eur J Pharmacol 1989;165:333-4.
33. Casscells W, Speir E, Bazoberry F, et al. Transforming growth factor-beta 1 in normal heart and myocardial infarction. Circulation 1989;80:II-452.
34. Kurihara H, Yoshizumi M, Sugiyama T, et al. Transforming growth factor-β stimulated the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun 1989;159: 1435-40.
35. Liu J, Casley DJ, Nayler WG. Ischaemia causes externalization of endothelin-1 binding sites in rat cardiac membranes. Biochem Biophys Res Commun 1989;164:1220-5.
36. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 1994;89:1203-8.
37. Li X-S, Wang Q-D, Pernow J. Beneficial effects of the endothelin receptor antagonist bosentan on myocardial and endothelial injury following ischaemia/reperfusion in the rat. Eur J Pharmacol 1995;283:161-8.
38. B receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol 1995;114:949-54.