A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 2, 1997, Pages 219-224

  Beeley, L J ^a   Berge, J M ^a   Chapman, H ^a   Dean, D K ^a   Kelly, J ^a   Lowden, K ^a   Kotecha, N R ^a   Morgan, H K A ^a   Rami, H K ^a   Thompson, M ^a   Vong, A K K ^a   Ward, R W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; NORADRENALIN;

ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RECEPTOR AFFINITY; RODENT; STRUCTURE ACTIVITY RELATION;

EID: 0031024462     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00603-8     Document Type: Article

References (18)

1. Riciquer, D. and Cassard-Doulcier, A., Eur. J. Biochem., 1993, 218, 785.
2. Arch, J. R. S., Ainsworth, A. T., Cawthorne, M. A., Piercy, V., Sennitt, M. V., Thody, V. E., Wilson, C. and Wilson, S., Nature, 1984, 309, 163.
3. Cantello B. C. C. and Smith S. A., Drugs of the Future, 1991, 16, 797.
4. Bloom, J. D. and Claus, T. H., Drugs of the Future, 1994, 19, 23.
5. Liggett, S., Mol. Pharm., 1992, 42, 634.
6. Kaiser, C., Jen, T., Garvey, E. Bowen, W. D., Colella, D. F. and Wardell, J. R., J. Med. Chem., 1977, 20, 687.
7. Yo, E., Nakagawa, K. and Hoshino, Y., Chem. Pharm. Bull., 1981, 29, 2157.
8. Hashimoto, Y., Ishizaki, T., Shudo, K. and Okamoto, T., Chem. Pharm. Bull., 1983, 31, 3891.
9. Klunder, J. M., Onami, T. and Sharpless, B. K., J. Org. Chem., 1989, 54, 1295.
10. Hammadi, A. and Crouzel, C., J. of Labelled Compounds and Radiopharmaceuticals, 1991, 29, 681.
11. Buckle, D. R., Foster, K. A., Taylor, J. F., Tedder, J. M., Thody, V. E., Webster, R. A. B., Bermudez, J., Markwell, R. E. and Smith, S. A., J. Med. Chem., 1987, 30, 2216.
12. Lunts, L. H. C., Medicinal Chemistry, 2nd Ed., edited by Ganellin, C.R. and Roberts, S. M., Academic Press Ltd., 1993, p. 212.
13. Lunts, L. H. C., Medicinal Chemistry, 2nd Ed., edited by Ganellin, C.R. and Roberts, S. M., Academic Press Ltd., 1993, p. 209.
14. Salomon, Y., Londos, C., and Rodbell, M., Analytical Biochem., 1974, 58, 541.
15. Takahashi, H., Nakano, K., Yasuda, T., Komiyama, Y., Murakami, T., Nishimura, M., Nakanishi, T., Sakamoto, M., Nanbu, A., and Yoshimura, M., Clinical and Experimental Pharmacology and Physiology, 1994, 21, 477.
16. Data from other compounds not reported here.
17. Beeley, L. J., Thompson, M., Dean, D. K., Kotecha, N., Berge, J.M. and Ward, R. W., International Patent Appl., Publication No. WO96/04233, 1996.
18. Synthesis to be reported elsewhere but for methodology see references 8, 9 and 16.