Effect of squalene, tocotrienols and α-tocopherol supplementations in the diet on serum and liver lipids in the hamster

Nutrition Research

Volumn 17, Issue 3, 1997, Pages 475-483

  Khor, H T ^a   Chieng, D Y ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Cholesterol; Hamsters; Liver Lipids; Serum Lipids; Squalene; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; CHOLESTEROL; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SQUALENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD INTAKE; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER;

EID: 0031024149     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(97)00006-7     Document Type: Article

References (25)

1. Liu GCK, Ahren Jr EH, Schreibman PH, Crouse JR. Measurement of squalene in human tissues and plasma: validation and application. J Lipid Res, 1976; 17:38-45;
2. Hassan AH. Palm oil and health. The Planters, 1988; 6: 505-17.
3. Keys A, Menotti A, Karnoven MJ, Aravain C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MH, Kromhout D, Nedeljkovic S, Punsar S, Seccareccia F, Toshima H. The diet and 15-year death rate in the seven countries study. Am J Epidemiol, 1986; 124: 903-15.
4. Strandberg TE, Silvis RS and Miettinen TA. Effect of cholestyramine and squalene feeding on hepatic and serum plant sterols in the rat. Lipids, 1989; 24: 705-8.
5. Miettinen TA and Kesaniemi YA. Cholesterol balance and lipoprotein metabolism in man. In: Grundy SM, ed. Bile acids and atherosclerosis. New York: Raven Press. 1986; p. 113-5.
6. Strandberg TE, Silvis RS and Miettinen TA. Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. J Lipid Res, 1990; 31:1637-43.
7. Miettinen TA, Vanhanen H. Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. Am J Clin Nutr, 1994; 59: 356-63.
8. Khor HT, Tan DTS. Serum lipid responses to simultaneous alterations in dietary palmitic and oleic acids in the absence and presence of dietary cholesterol in the hamster. Nutr Res, 1994; 14: 1191-99.
9. Khor HT, Chieng DY. Tocotrienols inhibit liver HMG CoA reductase activity in the guinea pig. Nutr Res, 1995; 15: 537-544.
10. Kostner GM. Enzymatic determination of cholesterol in HDL fraction prepared by polyanion precipitation. Clin. Chem., 1976; 22: 695.
11. Lopes-Virella MF, Stone P, Ellis S, Colwell JA. Cholesterol determination in HDL separated by 3 different methods. Clin Chem, 1977; 23:882-4.
12. Carroll, K.K. Column chromatography of neutral glycerides and fatty acids. In: Lipid chromatographic analysis. (G. V. Marinetti, ed.) 1976; vol. 2, p. 173-213.
13. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature, 1990; 343: 426-430.
14. Tilvis RS, Miettinen TA. Dietary squalene increases tissue sterols and fecal bile acids in the rat. Lipids, 1983; 18: 32-36.
15. Huang YS, Redden P and Lin X, smith R, Mackinnon S. Horrobin DF. Effect of dietary olive oil non-glyceride fraction on plasma cholesterol level and liver phospholipid fatty acid composition. Nutr Res, 1991; 11: 439-448.
16. Qureshi AA, Qureshi N, Hasler-RApacz JO, Weber FE, Chaudhary V, Crenshw TD, Gapor A, Ong ASH, Chong YH, Peterson D, Rapacz J. Dietary tocotrienols reduce concentrations of plasma cholesterol, apoprotein B, thromboxane B2 and platelet factor 4 in pigs with inherited hyperlipidemias. Am J Clin Nutr, 1991; 53:1242s-46s.
17. Watkins T, Len P, Gapor A, Struck M, Tomeo A, Bierenbaum M. γ-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. Lipids, 1993; 28: 1113-8.
18. Khor HT, Chieng DY. Effect of dietary supplementation of tocotrienols and tocopherols on serum lipids in the hamster. Nutr Res, 1996; 16: 1393-1401.
19. Tan DTS, Khor HT, Low WHS, Ahmad Ali, Gapor A. Effect of a palm oil vitamin E concentrate on the serum and lipoprotein lipids in humans. Am J Clin Nutr, 1991; 53: 1027s-30s.
20. Channon HJ. Biological significance of the unsaponifiable matters of oils. 1. Experiments with the unsaturated hydrocarbon, squalene (Spinacene). Biochem J, 1926; 20: 400-8.
21. Channon HJ, Tristram GR. The effect of the administration of squalene and other hydrocarbons on cholesterol metabolism in the rat. Biochem J, 1937; 31: 738-47.
22. Kritchevsky D, Moyer AW, Tesar WC, Logan JB, Brown RA, Richmond G. Squalene feeding in experimental atherosclerosis. Circ Res, 1954; 2: 340-43.
23. Beynen AC. Dietary monounsaturated fatty acids and liver cholesterol. Artery 1988; 15: 170-175.
24. Spady DK, Dietschy JM. Interaction of dietary cholesterol and triacylglycerols in the regulation of hepatic low density lipoprotein transport in the hamster. J. Clin. Invest, 1988; 81: 300-9.
25. Kritchevsky D, Tepper SA, Klurfeld DM, Vesselinovitch D, Wissler RW. Experimental atherosclerosis in rabbits fed cholesterol-free diets. Part 12. Comparison of peanut and olive oil. Atherosclerosis, 1984; 50:253-9.