The glycine site of the NMDA receptor contributes to neurokinin1 receptor agonist facilitation of NMDA receptor agonist-evoked activity in rat dorsal horn neurons

Brain Research

Volumn 744, Issue 2, 1997, Pages 235-245

  Heppenstall, P A ^a   Fleetwood Walker, S M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

dorsal horn; glycine; N methyl D aspartate receptor; neurokinin1 receptor; protein kinase C; substance P

Indexed keywords

1 AMINO 1,3 CYCLOBUTANEDICARBOXYLIC ACID; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3 (2 CARBOXY 4,6 DICHLORO 3 INDOLYL)PROPIONIC ACID; 5,7 DINITROQUINAXOLINE 2,3 DIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 7 CHLOROTHIOKYNURENIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CHELERYTHRINE; GLYCINE RECEPTOR; L 701252; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PROTEIN KINASE INHIBITOR; SUBSTANCE P DERIVATIVE; TACHYKININ RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IONTOPHORESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; GANGLIA, SPINAL; GLYCINE; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROKININ-1;

EID: 0031023397     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01065-7     Document Type: Article

References (72)

1. Allan, R.D., Hanrahan, J.R., Hambley, T.W., Johnston, G.A., Mewett, K.N. and Mitrovic, A.D., Synthesis and activity of a potent NMDA agonist, trans-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids, J. Med. Chem., 33 (1990) 2905-2915.
2. Battaglia, G. and Rustioni, A., Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey, J. Comp. Neurol., 277 (1988) 302-312.
3. Beyer, C., Banas, C., Gonzalez-Flores, O. and Komisurak, B.R., Blockage of substance P-induced scratching behaviour in rats by intrathecal administration of inhibitory amino acid agonists, Pharmacol. Biochem. Behav., 34 (1989) 491-495.
4. 1 receptor antagonists in nociceptive tests, Neuropeptides, 24 (1993) 219.
5. 1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that Substance P does not have a functional role on substantia gelatinosa (lamina II) neurons, J. Neurosci., 14 (1994) 7655-7664.
6. 3H]strychnine binding sites in rat brain, Eur. J. Pharmacol., 126 (1986) 303-307.
7. Budai, D., Wilcox, G.L. and Larson, A.A., Enhancement of NMDA-evoked neuronal activity by glycine in the rat spinal cord in vivo, Neurosci. Lett., 135 (1992) 265-268.
8. 1 antagonist on nociceptive transmission in the rat spinal cord, Neurosci. Lett., 157 (1993) 149-152.
9. Cumberbatch, M.J., Chizh, B.A. and Headley, P.M., Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord, Br. J. Pharmacol., 115 (1995) 1005-1012.
10. D'Angelo, E., Rossi, P. and Garthwaite, J., Dual component NMDA receptor currents at a single central synapse, Nature, 346 (1990) 467-470.
11. Davies, S.N. and Lodge, D., Evidence for involvement of N-methyl-aspartate receptors in 'wind-up' of class 2 neurons in the dorsal horn of the rat, Brain Res., 424 (1987) 402-406.
12. DeBiasi, S. and Rustioni, A., Glutamate and substance P coexist in primary afferent terminals in superficial laminae of spinal cord, Proc. Natl. Acad. Sci. USA, 85 (1983) 820-824.
13. DeKonick, Y., Ribeiro-da-Silva, A., Henry, J.L. and Cuello, A.C., Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts, Proc. Natl. Acad. Sci. USA, 89 (1992) 5073-5077.
14. Dickenson, A.H. and Aydar, E., Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat, Neurosci. Lett., 121 (1991) 263-266.
15. Dougherty, P.M. and Willis, W.D., Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of NMDA and substance P, Pain, 47 (1991) 85-93.
16. Dougherty, P.M. and Willis, W.D., Long-lasting enhancement of excitability of spinothalamic neurons following combined applica tion of excitatory amino acid and substance P in anaesthetized macaques, J. Physiol., 425 (1990) 38P.
17. Fletcher, E.J. and Lodge, D., Glycine reverses antagonism of NMDA by 1-hydroxy-3-aminopyrrolidine-2-one (HA-966), but not by D-2-Amino-5-phophonovalerate (D-AP5) on rat cortical slices, Eur. J. Pharmacol., 151 (1988) 161-162.
18. Haley, J.E., Sullivan, A.F. and Dickenson, A.H., Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat, Brain Res., 518 (1990) 216-226.
19. Herbert, J.N., Augereau, J.M., Gleye, J. and Maffrand, J.P., Chelerythrine is a potent and specific inhibitor of protein kinase C, Biochem. Biophys. Res. Commun., 192 (1990) 993-999.
20. Johnson, J.W, and Ascher, P., Glycine potentiates the NMDA response in cultured mouse brain neurons, Nature, 325 (1987) 529-531.
21. Kleckner, N.W. and Dingledine, R., Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocyctes, Science, 241 (1988) 835-837.
22. Kolhekar, R., Meller, S.T. and Gebhart, G.F., Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat, Neuroscience, 57 (1993) 385-395.
23. Kolhekar, R., Meller, S.T. and Gebhart, G.F., N-Methyl-D-aspartate receptor-mediated changes in thermal nociception: Allosteric modulation at glycine and polyamine recognition sites, Neuroscience, 63 (1994) 925-936.
24. Krogsgaard-Larsen, P., Honore, T., Hansen, J.J., Curtis, D.R. and Lodge, D., New class of glutamate agonist structurally related to ibotenic acid, Nature, 284 (1980) 64.
25. 1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the cat, Br. J. Pharmacol., 109 (1993) 713-718.
26. Larson, A.A. and Beitz, A.J., Glycine potentiates strychnine-induced convulsions: role of NMDA receptors, J. Neurosci., 8 (1988) 3822-3826.
27. Leeson, P.D. and Iversen, L.L., The glycine site on the NMDA receptor: Structure-activity relationships and therapeutic potential, J. Med. Chem., 37 (1994) 4053-4067.
28. 1 receptors, Neuroscience, 66 (1995) 597-608.
29. Liu, H., Brown, J.L., Jasmin, L., Maggio, J.E., Vigna, S.R., Mantyh, P.W. and Basbaum, A.I., Synaptic relations between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors, Proc. Natl. Acad. Sci. USA, 91 (1994) 1009-1013.
30. Luque, J.M., Bleuel, Z., Malherbe, P. and Richards, J.G., Alternatively spliced isoforms of the N-methyl-D-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord, Neuroscience, 63 (1994) 629-635.
31. Maehara, T., Suzuki, H., Yoshioka, K. and Otsuka, M., Substance P-evoked release of amino acid transmitters from the newborn rat spinal cord, Regul. Peptides, 46 (1993) 354-356.
32. 1 receptors on lumbar spinothalamic neurons in the rat, Neuroscience, 72 (1996) 255-263.
33. Millan, M.J. and Seguin, L., Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice, Neurosci. Lett., 178 (1994) 139-143.
34. Mjellem-Joly, N., Lund, A., Berge, O.-G. and Hole, K., Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test, Pain, 51 (1992) 195-198.
35. Moroni, F., Alesiani, M., Galli, A., Mori, F., Pecorari, R., Carla, V., Cherici, G. and Pellicciari, R., Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor, Eur. J. Pharmacol., 199 (1991) 227-232.
36. Munro, F.E., Fleetwood-Walker, S.M., Parker, R.M.C. and Mitchell, R., The effects of neurokinin receptor antagonists on mustard oil-evoked activation of rat dorsal horn neurons, Neuropeptides, 25 (1993) 299-305.
37. Murase, K., Ryu, P.D. and Randic, M., Excitatory and inhibitory amino acids and peptide induced responses in acutely isolated rat spinal dorsal horn neurones, Neurosci. Lett., 89 (1989) 305-312.
38. Nadler, V., Kloog, Y. and Sokolovsky, M., 1-Aminocyclopropane-1-carboxylic acid (ACPC) mimics the effects of glycine on the NMDA receptor ion channel, Eur. J. Pharmacol., 157 (1988) 115-116.
39. Nakanishi, S., Molecular diversity of glutamate receptors and implications for brain function, Science, 258 (1992) 507-603.
40. Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S. and Mizuno, N., Immunohistochemical localisation of substance P receptor in the central nervous system of the adult rat, J. Comp. Neurol., 347 (1994) 249-274.
41. Neugebauer, V., Lücke, T. and Schaible, H.-G., N-Methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyper-excitability of dorsal horn neurons during development of acute arthritis in rat's knee joint, J. Neurophysiol., 70 (1993) 1365-1377.
42. Nowak, L., Bregestovski, P., Ascher, P., Herbert, A. and Prochiantz, A., Magnesium gates glutamate-activated channels in mouse central neurones, Nature, 307 (1984) 462-465.
43. O'Shea, R.D., Mallanack, D.T., Conway, E.L., Mercer, L.D. and Beart, P.M., Evidence for heterogeneous glycine domains but conserved multiple states of the excitatory amino acid recognition site of the NMDA receptor, Exp. Brain Res., 86 (1991) 652-662.
44. Priestley, T. and Kemp, J.A., Agonist response kinetics of NMDA receptors in neurons cultured from rat cerebral cortex and cerebellum - evidence for receptor heterogeneity, Mol. Pharmacol., 44 (1993) 1252-1257.
45. Randic, M., Hecimovic, H. and Ryu, P.D., Substance P modulates glutamate-induced currents in acutely isolated rat dorsal horn neurons, Neurosci Lett., 117 (1990) 74-80.
46. Regoli, D., D'Orleans-Juste, P., Dion, S., Rhaleb, N.-E., Rouissi, N. and Drapeau, G., Neurokinin selective agonists. Discovery and pharmacologic applications, Regul. Peptides, 22 (1988) 153.
47. Reynolds, I.J., Arcaine is a competitive antagonist of the polyamine site of the NMDA receptor, Eur. J. Pharmacol., 177 (1990) 215-216.
48. Rowley, M., Leeson, P.D., Stevenson, G.I., Moseley, A.M., Stansfield, I., Sanderson, I., Robinson, L., Baker, R., Kemp, J.A., Marshall, G.R., et al., 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex, J. Med. Chem., 36 (1993) 3386-3396.
49. Rusin, K.I., Jiang, M.C., Cerne, R. and Randic, M., Interactions between excitatory amino acids and tachykinins in the rat spinal dorsal horn, Brain Res. Bull., 30 (1993) 329-338.
50. Rusin, K.I., Ryu, P.D. and Randic, M., Modulation of excitatory amino acid responses in rat dorsal horn neurons by tachykinins, J. Neurophysiol., 68 (1992) 265-286.
51. Salituro, F.G., Harrison, B.L., Baron, B.M., Nyce, P.L., Stewart, K.T., Kehne, J.H., White, H.S. and McDonald, I.A., 3-(2-carboxyindol-3-yl) propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site, J. Med. Chem., 35 (1992) 1791-1799.
52. Salt, T.E., Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo, Brain Res., 481 (1989) 403-406.
53. 2 receptor antagonists: a comparison to other classes of antinociceptive agent, Pain, 61 (1995) 325-343.
54. Seguin, L. and Millan, M.J., The glycine B receptor partial agonist, (+)-HA966, enhances induction of antinociception by RP 67580 and CP-99,994, Eur. J. Pharmacol., 253 (1994) R1-R3.
55. Sheardown, M.J., Dreyer, J., Jensen, L.H., Stidsen, C.E. and Honore, T., A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties, Eur. J. Pharmacol., 174 (1989) 197-204.
56. Sheardown, M.J., Nielsen, E.O., Hansen, A.J., Jacobsen, P. and Honore, T., 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline: a neuroprotectant for cerebral ischemia, Science, 247 (1990) 571.
57. A and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord, J. Neurophysiol., 72 (1994) 169-179.
58. Skilling, S.R., Smullin, D.H., Beitz, A.J. and Larson, A.A., Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation, J. Neurochem., 51 (1988) 127-132.
59. Smullin, D.H., Skilling, S.R. and Larson, A.A., Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord, Pain, 42 (1990) 93-101.
60. Sosnowski, M. and Yaksh, T.L., Spinal administration of receptor-selective drugs as analgesics: new horizons, J. Pain Symptom. Managem., 5 (1990) 204-213.
61. Thompson, A.M., Walker, V.E. and Flynn, D.M., Glycine enhances NMDA receptor-mediated synaptic potential in neocortical slices, Nature, 338 (1989) 422-424.
62. 1 neurokinin receptor activation and enhanced A-and C-fiber mediated responses in the rat spinal cord in vitro, J. Neurosc., 14 (1994) 3672-3687.
63. 2 receptor activation to high threshold afferent fibre evoked ventral root responses in the rat spinal cord, Brain Res., 625 (1993) 100-108.
64. Tokutomi, N., Kaneda, M. and Akaike, N., What confers specificity on glycine for its receptor site? Br. J. Pharmacol., 97 (1989) 353-360.
65. Tolle, T.R., Berthele, A., Zieglgansberger, W., Seeburg, P.H. and Wisden, W., The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray, J. Neurosci., 13 (1993) 5009-5028.
66. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle, F., Duhamel, L., Charon, G. and Kirilovsky, J., The bisindoylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C, J. Biol. Chem., 266 (2990) 15771-15781.
67. Urban, L., Thompson, S.W.N. and Dray, A., Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters, Trends Neurosci., 17 (1994) 432-438.
68. Watanabe, M., Mishina, M. and Inoue, Y., Distinct spatiotemporal distribution of the N-methyl-D-aspartate receptor channel subunit mRNAs in mouse cervical spinal cord, J. Comp. Neurol., 345 (1994) 314-319.
69. Wong, E.H., Kemp, J.A., Priestley, T., Knight, A.R., Woodruff, G.N. and Iversen, L.L., The anticonvulsant MK 801 is a potent NMDA antagonist, Proc. Natl. Acad. Sci. USA, 83 (1986) 7104-7108.
70. Xu, X.-J., Dalsgaard, C.-J. and Wiesenfeld-Hallin, Z., Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation, Eur. J. Pharmacol., 216 (1992) 337-344.
71. Xu, X.-J., Dalsgaard, C.-J. and Wiesenfeld-Hallin, Z., Spinal substance P and N-methyl-D-aspartate receptors are coactivated in the induction of central sensitization of the nociceptive flexor reflex, Neuroscience, 51 (1992) 641-648.
72. Yashpal, K., Radhakrishnan, V. and Henry, J.L., NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulation, Neurosci. Lett., 128 (1991) 269-272.