Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways

Journal of Medicinal Chemistry

Volumn 40, Issue 1, 1997, Pages 117-124

  Visser, Ton J ^a   Van Waarde, Aren ^a   Jansen, Twan J H ^a   Visser, Gerben M ^a   Van Der Mark, Thom W ^a   Kraan, Jan ^a   Ensing, Kees ^a   Vaalburg, Willem ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ATROPINE; CARBON 11; CHOLINERGIC RECEPTOR BLOCKING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYLPIPERIDIN 4 YL 2 CYCLOHEXYL 2 HYDROXY 2 PHENYLACETATE METHIODIDE; N METHYLQUINUCLIDINYL BENZILATE; QUINUCLIDIN 3 YL 2 CYCLOHEXYL 2 HYDROXYPHENYLACETATE METHIODIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; BINDING AFFINITY; BRONCHUS HYPERREACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIGAND BINDING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; SYNTHESIS; TISSUE DISTRIBUTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; KINETICS; MALE; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RESPIRATORY SYSTEM; STEREOISOMERISM; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031023359     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960374w     Document Type: Article

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