Direct measurement of doxorubicin concentration in the intact, living single cancer cell during hyperthermia

Cancer

Volumn 79, Issue 2, 1997, Pages 214-219

  Kawai, Hideki ^a   Minamiya, Yoshihiro ^a   Kitamura, Michihiko ^a   Matsuzaki, Ikuo ^a   Hashimoto, Masaji ^a   Suzuki, Hiroyuki ^a   Abo, Shichisaburo ^a  

^a AKITA UNIVERSITY   (Japan)

Author keywords

confocal laser scanning microscope; doxorubicin; hyperthermia; imaging; squamous cell carcinoma

Indexed keywords

DOXORUBICIN;

ARTICLE; CANCER CELL CULTURE; CELL LEVEL; CELL NUCLEUS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFECT; DRUG SENSITIVITY; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, SQUAMOUS CELL; DOXORUBICIN; ESOPHAGEAL NEOPLASMS; HUMANS; HYPERTHERMIA, INDUCED; TUMOR CELLS, CULTURED;

EID: 0031023326     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19970115)79:2<214::AID-CNCR3>3.0.CO;2-K     Document Type: Article

References (22)

1. Tsukiyama I, Ogino T, Egawa S. Hyperthermia for bone and soft tissue sarcoma: relationship between computerized tomographic and histological findings. Radiat Med 1994; 12:231-6.
2. Di Filippo F, Carlini S, Garinei R, Perri P, Anza M, Ferranti F, et al. Local hyperthermia and systemic chemotherapy for treatment of recurrent melanoma. World J Surg 1995; 19:359-62.
3. Sugimachi K, Kuwano H, Ide H, Toge T, Saku M, Oshiumi Y. Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial. Int J Hyperthermia 1994;10:485-93.
4. Colombo R, Lev A, Da Pozzo LF, Freschi M, Callus G, Rigatti P. A new approach using local combined microwave hyperthermia and chemotherapy in superficial transitional bladder carcinoma treatment. J Urol 1995;153:959-63.
5. Shchepotin IB, Buras RR, Nauta RJ, Shabahang M, Soldatenkov VA, Evans SR. In vitro effect of 5-fluorouracil, verapamil and hyperthermia on the human pancreatic adenocarcinoma cell line ASPC-I. Chemotherapy 1994;40:348-56.
6. Shidnia H, Hornback N, Ford G, Shen RN. Clinical experience with hyperthermia in conjunction with radiation therapy. Oncology 1993;50:353-61.
7. Matsuda H, Tsutsui S, Morita M, Baba K, Kitamura K, Kuwano H, et al. Hyperthermo-chemo-radiotherapy as a definitive treatment for patients with early esophageal carcinoma. Am J Clin Oncol 1992;15:509-14.
8. Sakaguchi Y, Maehara Y, Inutsuka S, Takahashi I, Yoshida M, Emi Y, et al. Laser flow cytometric studies on the intracellular accumulation of anthracyclines when combined with heat. Cancer Chemother Pharmacol 1994;33:371-7.
9. Siegal A, Hoenig S, Leibovici J. Combined effect in vitro of chemotherapy with agents acting on the cell membrane of Lewis lung carcinoma. Chemotherapy 1990;36:230-9.
10. Leibovici J, Klorin G, Huszar M, Hoenig S, Klein O, Michowitz M, et al. Sensitivity to thermochemotherapy of AKR lymphoma and B16 melanoma variants of malignancy. Clin Exp Metastasis 1990;8:33-46.
11. Los G, van Vugt MJ, Pinedo HM. Response of peritoneal solid tumours after intraperitoneal chemohyperthermia treatment with cisplatin or carboplatin. Br J Cancer 1994;69:235-41.
12. Miyahara T, Ueda K, Akaboshi M, Shimada Y, Imamura M, Utsumi H. Hyperthermic enhancement of cytotoxicity and increased uptake of cis-diamminedichloroplatinum(II) in cultured human esophageal cancer cells. Jpn J Cancer Res 1993;84:336-40.
13. Asaumi J, Kawasaki S, Nishikawa K, Kuroda M, Hiraki Y. Effects of hyperthermia and cepharanthin on Adriamycin accumulation with changes in extracellular pH. Int J Hyperthermia 1995;11:27-35.
14. Sandison DR, Williams RM, Wells KS, Strickler J, Webb WW. Quantitative fluorescence confocal laser scanning microscopy (CLSM). In: Pawley JB. Handbook of biological confocal microscopy. New York: Plenum Press, 1995:39-53.
15. Meschini S, Molinari A, Calcabrini A, Citro G, Arancia G. Intracellular localization of the antitumour drug Adriamycin in living cultured cells: a confocal microscopy study. J Microsc 1994;176:204-10.
16. Molinari A, Cianfriglia M, Meschini S, Calcabrini A, Arancia G. P-glycoprotein expression in the Golgi apparatus of multi-drug-resistant cells. Int J Cancer 1994;59:789-95.
17. Kabuto M, Kubota T, Kobayashi H, Nakagawa T, Arai Y, Kitai R. Subcellular localization and cellular pharmacokinetics of MX2, a new morpholino anthracycline in glioma cells using confocal laser scanning microscopy. Neural Res 1994; 16:257-64.
18. Gabby EJ, Grier D, Fingerle RE, Reimer R, Levy R, Pearce SW. Intercation specificity of anthracyclines with deoxyribonucleic acid. Biochemistry 1976;15:2062-70.
19. Jevtovic TV, Guenthner TM. Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro. Biochem Pharmacol 1992;44:1383-93.
20. Colombo R, Necco A, Vailati G, Milzani A, Dose-dependence of doxorubicin effect on actin assembly in vitro. Exp Mol Pathol 1988;49:297-304.
21. Molinari A, Calcabrini A, Crateri P, Arancia G. Interaction of anthracyclinic antibiotics with cytoskeletal components of cultured cells (CG5). Exp Mol Pathol 1990;53:4645-9.
22. Tritton TR, Yee G. The anticancer agent Adriamycin can be actively cytotoxic without entering the cells. Science 1982;217:248-50.