Elevated levels of soluble thrombomodulin in plasma from children with Arg 506 to Gln mutation in the factor V gene

European Journal of Haematology

Volumn 58, Issue 1, 1997, Pages 51-55

  Nowak Gottl U ^a,b   Vielhaber, H ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Arg506 Gln mutation; childhood; protein C; thrombomodulin

Indexed keywords

BLOOD CLOTTING FACTOR 5; D DIMER; PROTEIN C; PROTEIN S; THROMBOMODULIN;

ADOLESCENT; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD LEVEL; CHILD; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRIORITY JOURNAL; THROMBOEMBOLISM;

EID: 0031023276     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1997.tb01410.x     Document Type: Article

References (13)

1. ESMON CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FABS 1995: 9: 946-955.
2. TAKANO S, KIMURA S, OHODAMA S, AOKI N. Plasma thrombomodulin in health and disease. Blood 1990: 79: 837-838.
3. WADA H, OHIWA M, KANEKO T, et al. Plasma thrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation. Am J Haematol 1992: 39: 20-24.
4. IWASHIMA Y, SATO T, WATANABE K, et al. Elevation of plasma thrombomodulin level in diabetic patients with early diabetic nephropathy. Diabetes 1990: 39: 983-988.
5. HOSHI K, INOUE T, KAKOI H, et al. Plasma thrombomodulin levels in coronary sinus blood in patients with artery disease. Blood Coag Fibrinol 1995: 6: 129-132.
6. OHDAMA S, YOSHIZAWA Y, KUBOTA T, AOKI N. Plasma thrombomodulin as an indicator of thromboembolic disease in systemic lupus erythematosus. Int J Cardiol 1994 47/2: S1-S6.
7. VAN DEN BERG M, BOERS GHJ, FRANKEN DG, et al. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest 1995: 25: 176-181.
8. NOWAK-GÖTTL U, KOCH HG, ASCHKA I, et al. Resistance to activated protein C (APCR) in children with venous or arterial thromboembolism. Br J Haematol 1996: 92: 992-998.
9. VIELHABER H, KOHLHASE B, KOCH HG, et al. Flush heparin during cardiac catheterisation prevents long-term coagulation activation in children without APC-resistance - preliminary results. Thromb Res 1996: 81: 651-656.
10. LEROY-MATHERON C, LEVELNT M, PIGNON JM, MENDOCA C, GOUAULT-HEILMANN M. The 1691G A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients. Thromb Haemost 1996: 75: 4-10.
11. SIMIONI P, SCARANO L, GAVASSO S, et al. Prothrombin fragment 1+2 and thrombin-antithrombin complex levels in patients with inherited APC resistance due to factor V Leiden mutation. Br J Haematol 1996: 92: 435-441.
12. ZöLLER B, HOLM J, SVENSSON P, DAHLBÄCK B. Elevated levels of prothrombin activation fragment 1+2 in plasma from patients with heterozygous Arg 506 to Gln mutation in the factor V gene. Thromb Haemost 1996: 75: 270-274.
13. GREENGARD JS, EICHINGER S, GRIFFIN JH, BAUER KA. Brief report: variability of thrombosis among homozygous siblings with resistance to activated protein C due to an Arg Gln mutation in the gene for factor V. N Engl J Med 1994: 331: 1559-1562.