메뉴 건너뛰기




Volumn 26, Issue 1, 1997, Pages 203-208

Transient inhibition by orotic acid does not abolish the in vivo response of rat hepatocytes to a direct mitogen, lead nitrate

Author keywords

cell proliferation; hepatocyte; inhibition; mitogenic stimulus; orotic acid

Indexed keywords

OROTIC ACID;

EID: 0031023111     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80027-X     Document Type: Article
Times cited : (2)

References (33)
  • 1
    • 0021025217 scopus 로고
    • Dietary orotic acid enhances the incidence of (γ-glutamyl-transferase positive foci in rat liver induced by chemical carcinogens
    • Rao PM, Nagamine K, Ho R-K, Roomi MW, Laurier C, Rajalakshmi S, Sarma DSR. Dietary orotic acid enhances the incidence of (γ-glutamyl-transferase positive foci in rat liver induced by chemical carcinogens. Carcinogenesis. 4:1983;1541-1545.
    • (1983) Carcinogenesis , vol.4 , pp. 1541-1545
    • Rao, P.M.1    Nagamine, K.2    Ho R-K3    Roomi, M.W.4    Laurier, C.5    Rajalakshmi, S.6    Sarma, D.S.R.7
  • 2
    • 0021358218 scopus 로고
    • Promotion by orotic acid of liver carcinogenesis in rats initiated by 1, 2-dimethylhydrazine
    • Laurier C, Tatematsu M, Rao PM, Rajalakshmi S, Sarma DSR. Promotion by orotic acid of liver carcinogenesis in rats initiated by 1, 2-dimethylhydrazine. Cancer Res. 44:1984;2186-2191.
    • (1984) Cancer Res , vol.44 , pp. 2186-2191
    • Laurier, C.1    Tatematsu, M.2    Rao, P.M.3    Rajalakshmi, S.4    Sarma, D.S.R.5
  • 3
    • 0027328219 scopus 로고
    • Increasing the interval between initiation and the onset of exposure to orotic acid decreases its promoting effect on rat liver carcinogenesis
    • Laconi E, Vasudevan S, Rao PM, Rajalakshmi S, Pani P, Sarma DSR. Increasing the interval between initiation and the onset of exposure to orotic acid decreases its promoting effect on rat liver carcinogenesis. Carcinogenesis. 14:1993;1701-1704.
    • (1993) Carcinogenesis , vol.14 , pp. 1701-1704
    • Laconi, E.1    Vasudevan, S.2    Rao, P.M.3    Rajalakshmi, S.4    Pani, P.5    Sarma, D.S.R.6
  • 4
    • 0027495582 scopus 로고
    • The effect of long-term feeding of orotic acid on the incidence of foci of enzyme-altered hepatocytes and hepatic nodules in Fischer 344 rats
    • Laconi E, Vasudevan S, Rao PM, Rajalakshmi S, Pani P, Sarma DSR. The effect of long-term feeding of orotic acid on the incidence of foci of enzyme-altered hepatocytes and hepatic nodules in Fischer 344 rats. Carcinogenesis. 14:1993;1901-1905.
    • (1993) Carcinogenesis , vol.14 , pp. 1901-1905
    • Laconi, E.1    Vasudevan, S.2    Rao, P.M.3    Rajalakshmi, S.4    Pani, P.5    Sarma, D.S.R.6
  • 5
    • 0027732020 scopus 로고
    • The development of hepatocellular carcinoma in initiated rat liver after a brief exposure to orotic acid coupled with partial hepatectomy
    • Laconi E, Vasudevan S, Rao PM, Rajalakshmi S, Pani P, Sarma DSR. The development of hepatocellular carcinoma in initiated rat liver after a brief exposure to orotic acid coupled with partial hepatectomy. Carcinogenesis. 14:1993;2527-2530.
    • (1993) Carcinogenesis , vol.14 , pp. 2527-2530
    • Laconi, E.1    Vasudevan, S.2    Rao, P.M.3    Rajalakshmi, S.4    Pani, P.5    Sarma, D.S.R.6
  • 6
    • 84968989967 scopus 로고
    • Influence of dietary orotic acid on hepatocarcinogenesis in Fischer-344 and Sprague-Dawley rats
    • Elliot TS, Robinson JL, Visek WJ. Influence of dietary orotic acid on hepatocarcinogenesis in Fischer-344 and Sprague-Dawley rats. FASEB J. 46:1987;746A.
    • (1987) FASEB J. , vol.46
    • Elliot, T.S.1    Robinson, J.L.2    Visek, W.J.3
  • 7
    • 0026096574 scopus 로고
    • Enhancement of N-nitroso(2-hydroxypropyl)(2-oxypropyl)amine-induced tumorigenesis in Sprague-Dawley rats by orotic acid
    • Kokkinakis DM, Scarpelli DG, Oyasu R. Enhancement of N-nitroso(2-hydroxypropyl)(2-oxypropyl)amine-induced tumorigenesis in Sprague-Dawley rats by orotic acid. Carcinogenesis. 12:1992;181-186.
    • (1992) Carcinogenesis , vol.12 , pp. 181-186
    • Kokkinakis, D.M.1    Scarpelli, D.G.2    Oyasu, R.3
  • 8
    • 0027988018 scopus 로고
    • Orotic acid enhancement of preneoplastic and neoplastic lesions induced in the pancreas and liver of hamsters by N-nitroso(2-hydroxypropyl)(2-oxypropyl)amine
    • Kokkinakis DM, Albores-Saavedra J. Orotic acid enhancement of preneoplastic and neoplastic lesions induced in the pancreas and liver of hamsters by N-nitroso(2-hydroxypropyl)(2-oxypropyl)amine. Cancer Res. 54:1994;5324-5332.
    • (1994) Cancer Res , vol.54 , pp. 5324-5332
    • Kokkinakis, D.M.1    Albores-Saavedra, J.2
  • 9
    • 0343628097 scopus 로고
    • Orotic acid, a novel tumor promoter: Studies on the mechanism of its action.
    • Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Laconi E, Vasudevan S, Rao PM, Rajalakshmi S, Sarma DSR. Orotic acid, a novel tumor promoter: studies on the mechanism of its action. Bambury Reports. 25:1987;85-90 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1987) Bambury Reports , vol.25 , pp. 85-90
    • Laconi, E.1    Vasudevan, S.2    Rao, P.M.3    Rajalakshmi, S.4    Sarma, D.S.R.5
  • 12
    • 0025299497 scopus 로고
    • Inhibitory effects of orotate on precursor incorporation into nucleic acids
    • Lea M, Luke A, Assad A, Ayyala S. Inhibitory effects of orotate on precursor incorporation into nucleic acids. Chem Biol Interact. 75:1990;49-59.
    • (1990) Chem Biol Interact , vol.75 , pp. 49-59
    • Lea, M.1    Luke, A.2    Assad, A.3    Ayyala, S.4
  • 13
    • 0025024708 scopus 로고
    • Relationship between poly(ADP-rybose) polymerase activity and DNA synthesis in cultured hepatocytes
    • Cesarone CF, Scarabelli L, Giannoni P, Gallo G, Orunesu M. Relationship between poly(ADP-rybose) polymerase activity and DNA synthesis in cultured hepatocytes. Biochem Biophys Res Commun. 171:1990;1037-1043.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 1037-1043
    • Cesarone, C.F.1    Scarabelli, L.2    Giannoni, P.3    Gallo, G.4    Orunesu, M.5
  • 14
    • 0027157230 scopus 로고
    • Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules
    • Sheikh A, Yusuf A, Laconi E, Rao PM, Rajalakshmi S, Sarma DSR. Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules. Carcinogenesis. 14:1993;907-912.
    • (1993) Carcinogenesis , vol.14 , pp. 907-912
    • Sheikh, A.1    Yusuf, A.2    Laconi, E.3    Rao, P.M.4    Rajalakshmi, S.5    Sarma, D.S.R.6
  • 15
    • 0027434475 scopus 로고
    • Influence of orotic acid on multistage hepatocarcinogenesis in the rat: Resistance of hepatocyte from nodules to the mitoinhibitory effect of orotic acid
    • Manjeshwar S, Laconi E, Rao PM, Rajalakshmi S, Sarma DSR. Influence of orotic acid on multistage hepatocarcinogenesis in the rat: resistance of hepatocyte from nodules to the mitoinhibitory effect of orotic acid. Proc Soc Exp Biol Med. 202:1993;25-29.
    • (1993) Proc Soc Exp Biol Med , vol.202 , pp. 25-29
    • Manjeshwar, S.1    Laconi, E.2    Rao, P.M.3    Rajalakshmi, S.4    Sarma, D.S.R.5
  • 18
    • 0020659412 scopus 로고
    • Liver cell proliferation induced by a single dose of lead nitrate
    • Columbano A, Ledda GM, Sirigu P, Perra T, Pani P. Liver cell proliferation induced by a single dose of lead nitrate. Am J Pathol. 110:1983;83-86.
    • (1983) Am J Pathol , vol.110 , pp. 83-86
    • Columbano, A.1    Ledda, G.M.2    Sirigu, P.3    Perra, T.4    Pani, P.5
  • 19
    • 0018400840 scopus 로고
    • Adaptive liver growth induced by xenobiotic compounds: Its nature and mechanisms
    • Schulte-Hermann R. Adaptive liver growth induced by xenobiotic compounds: its nature and mechanisms. Arch Toxicol, Suppl. 2:1979;113-124.
    • (1979) Arch Toxicol, Suppl , vol.2 , pp. 113-124
    • Schulte-Hermann, R.1
  • 20
    • 0023571510 scopus 로고
    • Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens
    • Columbano A, Ledda-Columbano GM, Lee G, Rajalakshmi S, Sarma DSR. Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens. Cancer Res. 47:1987;5557-5559.
    • (1987) Cancer Res , vol.47 , pp. 5557-5559
    • Columbano, A.1    Ledda-Columbano, G.M.2    Lee, G.3    Rajalakshmi, S.4    Sarma, D.S.R.5
  • 21
    • 0027445659 scopus 로고
    • Ribonucleotide reductase: A possible target for orotic acid induced mitoinhibition in normal hepatocytes in primary culture
    • Manjeshwar S, Pichiri-Coni G, Coni P, Rao PM, Rajalakshmi S, Sarma DSR. Ribonucleotide reductase: a possible target for orotic acid induced mitoinhibition in normal hepatocytes in primary culture. Cancer Lett. 73:1993;149-154.
    • (1993) Cancer Lett , vol.73 , pp. 149-154
    • Manjeshwar, S.1    Pichiri-Coni, G.2    Coni, P.3    Rao, P.M.4    Rajalakshmi, S.5    Sarma, D.S.R.6
  • 22
    • 0016108703 scopus 로고
    • Induction of liver growth by xenobiotic compounds and other stimuli
    • Schulte-Hermann R. Induction of liver growth by xenobiotic compounds and other stimuli. Crit Rev Toxicol. 3:1974;97-158.
    • (1974) Crit Rev Toxicol , vol.3 , pp. 97-158
    • Schulte-Hermann, R.1
  • 23
    • 0022507417 scopus 로고
    • Regulation of hepatic growth
    • Alison MR. Regulation of hepatic growth. Physiol Rev. 66:1986;499-541.
    • (1986) Physiol Rev , vol.66 , pp. 499-541
    • Alison, M.R.1
  • 24
    • 0022542049 scopus 로고
    • Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle
    • Kuki P, Vanderlaan NM, Dolbare F, Gray J, Tan EM. Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res. 166:1987;209-219.
    • (1987) Exp Cell Res , vol.166 , pp. 209-219
    • Kuki, P.1    Vanderlaan, N.M.2    Dolbare, F.3    Gray, J.4    Tan, E.M.5
  • 25
    • 0023091627 scopus 로고
    • Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ
    • Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ Nature. 326:1987;515-517.
    • (1987) Nature , vol.326 , pp. 515-517
    • Bravo, R.1    Frank, R.2    Blundell, P.A.3    Macdonald-Bravo, H.4
  • 26
    • 0023091938 scopus 로고
    • Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein
    • Prelich G, Cheng-Keat T, Kostura M, Mathew MB, So AG, Downey KM, Stillman B. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein. Nature. 326:1987;517-520.
    • (1987) Nature , vol.326 , pp. 517-520
    • Prelich, G.1    Cheng-Keat, T.2    Kostura, M.3    Mathew, M.B.4    So, A.G.5    Downey, K.M.6    Stillman, B.7
  • 27
    • 0025122144 scopus 로고
    • Liver regeneration: Molecular mechanisms of growth control
    • Michalopoulos GK. Liver regeneration: molecular mechanisms of growth control. FASEB J. 4:1990;240-249.
    • (1990) FASEB J , vol.4 , pp. 240-249
    • Michalopoulos, G.K.1
  • 28
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • Pardee AB. A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA. 71:1974;1286-1290.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 29
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury C, Nurse P. Animal cell cycles and their control. Ann Rev Biochem. 61:1992;441-470.
    • (1992) Ann Rev Biochem , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 30
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of the cell cycle events
    • Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of the cell cycle events. Science. 246:1989;629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 31
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ. G1 phase progression: cycling on cue. Cell. 79:1994;551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 33
    • 0029069867 scopus 로고
    • Qualifying for the licence to replicate
    • Su TT, Follette PJ, O'Farrell PH. Qualifying for the licence to replicate. Cell. 81:1995;825-828.
    • (1995) Cell , vol.81 , pp. 825-828
    • Su, T.T.1    Follette, P.J.2    O'Farrell, P.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.