A novel antibody-dependent cellular cytotoxicity epitope in gp120 is identified by two monoclonal antibodies isolated from a long-term survivor of human immunodeficiency virus type 1 infection

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 925-933

  Alsmadi, Osama ^a,b   Herz, Ruth ^a,c   Murphy, Ellen ^a,d   Pinter, Abraham ^a   Tilley, Shermaine A ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d Applied Microbiology Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 120;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY SPECIFICITY; ANTIVIRAL ACTIVITY; ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031022818     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.925-933.1997     Document Type: Article

References (45)

1. Alsmadi, O., et al. Unpublished data.
2. Belo, M., M. Yagello, M. Girard, R. Greenlee, A. Deslandres, F. Barre-Sinoussi, and J. C. Gluckman. 1991. Antibody-dependent cellular cytotoxicity against HIV-1 in sera of immunized chimpanzees. AIDS 5:169-176.
3. Burton, D. R., J. Pyati, R. Koduri, S. J. Sharp, G. B. Thornton, P. W. H. I. Parren, L. S. W. Sawyer, R. M. Hendry, N. Dunlop, P. L. Nara, M. Lamacchia, E. Garratty, E. R. Stiehm, Y. J. Bryson, Y. Cao, J. P. Moore, D. D. Ho, and C. F. Barbas III. 1994. Efficient neutralization of primary isolates of HIV-I by a recombinant human monoclonal antibody. Science 266:1024-1027.
4. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D. D. Ho. 1995. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N. Engl. J. Med. 332:201-208.
5. Clerici, M., and G. M. Shearer. 1994. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol. Today 15:575-581.
6. Connor, R. I., N. B. Dinces, A. L. Howell, J. L. Romet-Lemonne, J. L. Pasquali, and M. W. Fanger. 1991. Fc receptors for IgG (FcγRs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-I): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the FcγR. Proc. Natl. Acad. Sci. USA 88:9593-9597.
7. Earl, P. L., A. W. Hugin, and B. Moss. 1990. Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus. J. Virol. 64:2448-2451.
8. Ferrari, G., J. Ottinger, C. Place, S. M. Nigida, Jr., L. O. Arthur, and K. J. Weinhold. 1993. The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees. AIDS Res. Hum. Retroviruses 9:647-656.
9. Folks, T., S. Benn, A. Rabson, T. Theodore, M. D. Hoggan, M. Martin, M. Lightfoote, and K. Sell. 1985. Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus, Proc. Natl. Acad. Sci. USA 82:4539-4543.
10. Gorny, M. K., J.-Y. Xu, S. Karwowska, A. Buchbinder, and S. Zolla-Pazner. 1993. Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-I gp120. J. Immunol. 150:635-643.
11. Homsy, J., M. Meyer, M. Tateno, S. Clarkson, and J. A. Levy. 1989. The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244:1357-1360.
12. Howell, A. L., P. M. Guyre, K. You, and M. W. Fanger. 1994. Targeting HIV-I to FcγR on human phagocytes via bispecific antibodies reduces infectivity of HIV-1 to T cells. J. Leukocyte Biol. 55:385-391.
13. Howell, D. N., P. E. Andreotti, J. R. Dawson, and P. Cresswell. 1985. Natural killing target antigens as inducers of Interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line. J. Immunol. 134:971-976.
14. Karwowska, S., M. K. Gorny, A. Buchbinder, V. Gianakakos, C. Williams, T. Fuerst, and S. Zolla-Pazner. 1992. Production of human monoclonal antibodies specific for conformational and linear non-V3 epitopes of gp120. AIDS Res. Hum. Retroviruses 8:1099-1106.
15. Kostrikis, L. G., Y. Cao, H. Ngai, J. P. Moore, and D. D. Ho. 1996. Quantitative analysis of serum neutralization of human immunodeficiency virus type 1 from subtypes A, B, C, D, E, F, and I: lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent infectivity enhancement. J. Virol. 70:445-458.
16. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
17. Laal, S., S. Burda, M. K. Gorny, S. Karwowska, A. Buchbinder, and S. Zolla-Pazner. 1994. Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies. J. Virol. 68:4001-4008.
18. Lee, C-N., J. Robinson, Y.-L. Cheng, M. Essex, and T.-H. Lee. 1994. Influence of deletions in N or C terminus of HIV-I glycoprotein 120 on binding of infectivity enhancing antibody. AIDS Res. Hum. Retroviruses 10:1065-1069.
19. Ljunggren, K., V. Moschese, P. A. Broliden, C. Giaquinto, I. Quinti, E. M. Fenyo, B. Wahren, P. Rossi, and M. Jondal. 1990. Antibodies mediating cellular cytotoxicity and neutralization correlate with a better clinical stage in children born to human immunodeficiency virus-infected mothers. J. Infect. Dis. 161:198-202.
20. Lyerly, H. K., T. J. Matthews, A. J. Langlois. D. P. Bolognesi, and K. J. Weinhold. 1987. Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack. Proc. Natl. Acad. Sci. USA 84:4601-4605.
21. Mabondzo, A., P. Aussage, J. Bartholeyns, R. Le Naour, H. Raoul, J. L. Romet-Lemonne, and D. Dormont. 1992. Bispecific antibody targeting of human immunodeficiency virus type 1 (HIV-I) glycoprotein 41 to human macrophages through the Fc IgG receptor I mediates neutralizing effects in HIV-I infection. J. Infect. Dis. 166:93-99.
22. Mabondzo, A., F. Boussin, H. Raoul, R. Le Naour, G. Gras, B. Vaslin, J. Bartholeyns, J. L. Romet-Lemonne, and D. Dormont. 1994. Antibody-dependent cellular cytotoxicity and neutralization of human immunodeficiency virus type 1 by high affinity cross-linking of gp41 to human macrophage Fc IgG receptor using bispecific antibody. J. Gen. Virol. 75:1451-1456.
23. Vlascola, J. R., B. J. Mathieson, P. M. Zack, M. C. Walker, S. B. Halstead, and D. S. Burke. 1993. Summary report: workshop on the potential risks of antibody-dependent enhancement in human HIV vaccine trials. AIDS Res. Hum. Retroviruses 9:1175-1184.
24. Matsushita, S., M. Robert-Guroff, J. Rusche, A. Koito, T. Hattori, H. Hoshino, K. Javaherian, K. Takatsuki, and S. Putney. 1988. Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralization epitope. J. Virol. 62:2107-2114.
25. McCutchan, F. E., P. A. Hegerich, T. P. Brennan, P. Phanuphak, P. Singharaj, A. Jugsudee, P. W. Berman, A. M. Gray, A. K. Fowler, and D. S. Burke. 1992. Genetic variants of HIV-1 in Thailand. AIDS Res. Hum. Retroviruses 8:1887-1895.
26. Montefiori, D. C., G. Pantaleo, L. M. Fink. J. T. Zhou, J. Y. Zhou, M. Bilska, G. D. Miralles, and A. S. Fauci. 1996. Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors. J. Infect. Dis. 173:60-67.
27. Ojo-Amaize, E. A., P. Nishanian, D. E. Keith, R. L. Houghton, D. F. Heitjan, J. L. Fahey, and J. V. Giorgi. 1987. Antibodies to human immunodeficiency virus in human sera induce cell-mediated lysis of human immunodeficiency virus-infected cells. J. Immunol. 139:2458-2463.
28. Palker, T. J., T. J. Matthews, M. E. Clark, G. J. Cianciolo, R. R. Randall, A. J. Langlois, G. C. White, B. Safai, R. Snyderman, D. P. Bolognesi, and B. F. Haynes. 1987. A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. Proc. Natl. Acad. Sci. USA 84:2479-2483.
29. Pinter, A., W. J. Honnen, M. E. Racho, and S. A. Tilley. 1993. A potent, neutralizing human monoclonal antibody against a unique epitope overlapping the CD4-binding site of HIV-I gp120 that is broadly conserved across North American and African virus isolates. AIDS Res. Hum. Retroviruses 9:985-996.
30. Pinter, A., W. J. Honnen, and S. A. Tilley. 1993. Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites. J. Virol. 67:5692-5697.
31. Posner, M. R., H. S. Elboint, T. Cannon, L. Cavacini, and T. Hideshima. 1992. Functional activity of an HIV-I neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis. AIDS Res. Hum. Retroviruses 8:553-558.
32. Robinson, J. E., D. Holton, S. Pacheco-Morell, J. Liu, and H. McMurdo. 1990. Identification of conserved and variant epitopes of human immunodeficiency virus type 1 (HIV-I) gp120 by human monoclonal antibodies produced by EBV-transformed cell lines. AIDS Res. Hum. Retroviruses 6:567-579.
33. Robinson, W. E., T. Kawamura, M. K. Gorny, D. C. Monteflori, W. M. Mitchell, D. Lake, J. Xu, Y. Malsumoto, T. Sugano, Y. Masuho, E. Hersh, and S. Zolla-Pazner. 1990. Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-I) transmemhranc glycoprotein gp41 enhance HIV-I infection in vitro. Proc. Natl. Acad. Sci. USA 87:3185-3189.
34. Sawyer, L. A., D. A. Katzenstein, R. M. Hendry, E. J. Boone, L. K. Vujcic, C. C. Williams, S. L. Zeger, A. J. Saah, C. R. Rinaldo, Jr., J. P. Phair, J. V. Giorgi, and G. V. Quinnan, Jr. 1990. Possible beneficial effects of neutralizing antibodies and antibody-dependent, cell-mediated cytotoxicity in human immunodeficiency virus infection. AIDS Res. Hum. Retroviruses 6:341-365.
35. Shang, F., H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. 1991. Characterization of monoclonal antibodies against the HIV matrix protein, p17 gag: identification of an epitope exposed on the surface of infected cells. J. Virol. 65:4798-1804.
36. Sullivan, N., Y. Sun, J. Li, W. Hofmann, and J. Sodroski. 1995. Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J. Virol. 69:4413-4422.
37. Takeda, A.. J. E. Robinson, D. D. Ho, C. Debouck, N. L. Haigwood, and F. A. Ennis. 1992. Distinction of HIV-1 neutralization and infection-enhancement by human monoclonal antibodies to gp120. J. Clin. Invest. 89:1952-1957.
38. Takeda, A., R. W. Sweet, and F. A. Ennis. 1990. Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma. R. J. Virol. 64:5605-5610.
39. Tilley, S. A., et al. Unpublished data.
40. Tilley, S. A., W. J. Honnen, M. Racho, M. Hilgartner, and A. Pinter. 1991. A human monoclonal antibody against the CD4 binding site of HIV-1 gp120 exhibits potent, broadly neutralizing activity. Res. Virol. 142:247-259.
41. Tilley, S. A., W. J. Honnen, M. E. Racho, T. C. Chou, and A. Pinter. 1992. Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4 binding site of gp120. AIDS Res. Hum. Retroviruses 8:461-467.
42. Tilley, S. A., and A. Pinter. 1993. Human and chimpanzee monoclonal antibodies with antiviral activity against HIV-1, p. 255-287. In W. C. Koff. F. Wong-Staal. and R. C. Kennedy (ed.). AIDS research reviews, vol. 3. Marcel Dekker, Inc., New York. N.Y.
43. Warrier, S. V., A. Pinter, W. J. Honnen, M. Girard, E. Muchmore, and S. A. Tilley. 1994. A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody. J. Virol. 68:4636-4642.
44. Weinhold, K. J. 1990. Nonrestrieted forms of anti-HIV-1 cytotoxicity. p. 187-199. In A. Aldovini and B. D. Walker (ed.). Techniques in HIV research. Stockton Press. New York. N.Y.
45. Weinhold, K. J., T. J. Matthews, P. M. Ahearne, A. J. Langlois, H. K. Lyerly, D. S. Tyler, K. C. Stine, D. T. Durack, and D. P. Bolognesi. 1988. Cellular anti-gp120 cytolytic reactivities in HIV-1 seropositive individuals. Lancet i:902-905.