Novel synthesis of a conformationally-constrained analog of DDATHF

Tetrahedron Letters

Volumn 38, Issue 4, 1997, Pages 521-524

  Taylor, Edward C ^a   Zhou, Ping ^a   Jennings, Lee D ^a   Mao, Zhenmin ^a   Hu, Baihua ^a   Jun, Jong Gab ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID ANTAGONIST; LOMETREXOL;

ARTICLE; CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION;

EID: 0031021841     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02397-0     Document Type: Article

References (25)

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6. (f) Salaün, J.; Baird, M. S. Current Medicinal Chemistry 1995, 2, 511.
7. a) For the original synthesis, see Taylor, E. C.; Harrington, P. J.; Fletcher, S. R.; Beardsley, G. P.; Moran, R. G J. Med. Chem. 1985, 28, 914.
8. b) Beardsley, G. P.; Moroson, B. A.; Taylor, E. C.; Moran, R. G. J. Biol. Chem. 1989, 264, 328.
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11. e) For reviews of recent work, see Taylor, E. C. J. Heterocycl. Chem. 1990, 27, 1.
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21. This strategy had been employed for the conversion of methyl 4-nitro-2-methylbenzoate to diethyl 2-(2,3-dihydro-5-nitro-1-oxo-2(1H)-isoindolyl)-L-glutarate: Marsham, P. R.; Jackman, A. L.; Hayter, A. J.; Daw, M. R.; Snowden, J. L.; O'Connor, B. M.; Bishop, J. A. M.; Calvert, A. H.; Hughes, L. R. J. Med. Chem. 1991, 34, 2209.
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