메뉴 건너뛰기




Volumn 43, Issue 1-2, 1997, Pages 8-19

Alzheimer’s disease research: A game of connect the dots

Author keywords

Alzheimer s; Amyloid; ApoE; APP; Endosomal lysosomal; Glia; Tau

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; APOLIPOPROTEIN E; TAU PROTEIN;

EID: 0031021063     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000213832     Document Type: Article
Times cited : (13)

References (56)
  • 1
    • 0002121690 scopus 로고
    • The genetics of Alzheimer's disease and mutations in the amyloid G-protein precursor gene
    • Goate AM, Ashall F (eds), London, Academic Press
    • Busfield F, Goate AM: The genetics of Alzheimer's disease and mutations in the amyloid G-protein precursor gene: in Goate AM, Ashall F (eds): Pathobiology of Alzheimer’s Disease. London, Academic Press. 1995. pp 59-78.
    • (1995) Pathobiology of Alzheimer’s Disease , pp. 59-78
    • Busfield, F.1    Goate, A.M.2
  • 4
    • 0028387219 scopus 로고
    • Abnormality of the a-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
    • Sheu KF, Cooper AJ, Koike K, Koike M, Lindsay G, Blass JP: Abnormality of the a-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol 1994;35:312-318.
    • (1994) Ann Neurol , vol.35 , pp. 312-318
    • Sheu, K.F.1    Cooper, A.J.2    Koike, K.3    Koike, M.4    Lindsay, G.5    Blass, J.P.6
  • 6
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glcnncr GG, Wong CW: Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Com-mun 1984:120:885-890.
    • (1984) Biochem Biophys Res Com-Mun , vol.120 , pp. 885-890
    • Glcnncr, G.G.1    Wong, C.W.2
  • 8
    • 1842375935 scopus 로고
    • Biological Functions of the antyloid-p protein precursor
    • Goate AM, Ashall F (eds), London, Academic Press
    • Wagner SL: Biological Functions of the antyloid-p protein precursor: in Goate AM, Ashall F (eds): Pathobio-logy of Alzheimer’s Disease. London, Academic Press. 1995. pp 167-173.
    • (1995) Pathobio-Logy of Alzheimer’s Disease , pp. 167-173
    • Wagner, S.L.1
  • 9
    • 0023872043 scopus 로고
    • Novel precursor of Alzheimer’s disease shows protease inhibitory activity
    • Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H: Novel precursor of Alzheimer’s disease shows protease inhibitory activity. Nature 1988:331:530-532.
    • (1988) Nature , vol.331 , pp. 530-532
    • Kitaguchi, N.1    Takahashi, Y.2    Tokushima, Y.3    Shiojiri, S.4    Ito, H.5
  • 11
    • 0026735070 scopus 로고
    • Targeting of cell-surface p-amvloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ: Targeting of cell-surface p-amvloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments. Nature 1992;357:500-503.
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 13
    • 0028204224 scopus 로고
    • Calcium ionophore increases amyloid P peptide production by cultured cells
    • Querfurth HW, Selkoe DJ: Calcium ionophore increases amyloid P peptide production by cultured cells. Biochemistry 1994;33:4550-4561.
    • (1994) Biochemistry , vol.33 , pp. 4550-4561
    • Querfurth, H.W.1    Selkoe, D.J.2
  • 14
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA: Alzheimer's disease: The amyloid cascade hypothesis. Science 1992:256:184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 15
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arrigada PV, Growdon JH, Hedley-Whyte ET, Hyman BT: Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992; 42:631-639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arrigada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 16
    • 0025863618 scopus 로고
    • Ncuropathologi-cal stageing of Alzheimer-related changes
    • Braak H, Braak E: Ncuropathologi-cal stageing of Alzheimer-related changes. Acta Neuropathol 1991:82: 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 19
    • 0017649032 scopus 로고
    • Purification of tau. A microtu-bule-associated protein that induces assembly of microtubules from purified tubulin
    • Cleveland DW, Hwo SY, Kirschner MW: Purification of tau. a microtu-bule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 1977:116: 207-225.
    • (1977) J Mol Biol , vol.116 , pp. 207-225
    • Cleveland, D.W.1    Hwo, S.Y.2    Kirschner, M.W.3
  • 20
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and deriva-tized forms of normal tau
    • Lee VM, Balin, BJ, Otvos L, Troja-nowski JQ: A68: A major subunit of paired helical filaments and deriva-tized forms of normal tau. Science 1991;251:675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.1    Balin, B.J.2    Otvos, L.3    Troja-Nowski, J.Q.4
  • 21
    • 0026683725 scopus 로고
    • The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs
    • Gustke N, Steiner B, Mandclkow EM, Bicrnat J, Meyer HE, Goedert M, Mandetkow E: The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBSLett 1992;307:199-205.
    • (1992) Febslett , vol.307 , pp. 199-205
    • Gustke, N.1    Steiner, B.2    Mandclkow, E.M.3    Bicrnat, J.4    Meyer, H.E.5    Goedert, M.6    Mandetkow, E.7
  • 22
    • 0028305902 scopus 로고
    • Paired helical filament tau in Alzheimer’s disease: The kinase connection
    • Trojanowski JQ, Lee VM: Paired helical filament tau in Alzheimer’s disease: The kinase connection. Am J Pathol 1994;144:449-453.
    • (1994) Am J Pathol , vol.144 , pp. 449-453
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 23
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer’s disease paired helical filament tau
    • Matsuo ES, Shin RW, Billingsley ML, deVoorde AV, O’Connor M, Trojanowski JQ, Lee VM: Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer’s disease paired helical filament tau. Neuron 1994: 13:989-1002.
    • (1994) Neuron , vol.13 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.W.2    Billingsley, M.L.3    Devoorde, A.V.4    O’Connor, M.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 25
    • 0023505501 scopus 로고
    • Phosphorylation determines two distinct species of tau in the central nervous system
    • Papasozomenos SC, Binder LI: Phosphorylation determines two distinct species of tau in the central nervous system. Cell Motil Cyto-skeleton 1987;8:210-226.
    • (1987) Cell Motil Cyto-Skeleton , vol.8 , pp. 210-226
    • Papasozomenos, S.C.1    Binder, L.I.2
  • 26
    • 0024299370 scopus 로고
    • Apolipoprotcin E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW: Apolipoprotcin E: Cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-629.
    • (1988) Science , vol.240 , pp. 622-629
    • Mahley, R.W.1
  • 27
    • 0022350033 scopus 로고
    • Apolipo-protein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM: Apolipo-protein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985;76:1501-1513.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 30
    • 0027374047 scopus 로고
    • Apolipoprotcin E in sporadic Alzheimer’s disease: Allelic variation and receptor interactions
    • Rebeck GW, Reiter JS, Strickland DK, Hvmand BT: Apolipoprotcin E in sporadic Alzheimer’s disease: Allelic variation and receptor interactions. Neuron 1993:11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hvmand, B.T.4
  • 32
    • 0028109846 scopus 로고
    • The apolipoprotein E alleles as major susceptibility factors for Crcutzfeld-Jakob disease
    • Amouycl PA, Vidale O, Launay JM, Laplanche JL: The apolipoprotein E alleles as major susceptibility factors for Crcutzfeld-Jakob disease. Lancet 1994;344:1315-1318.
    • (1994) Lancet , vol.344 , pp. 1315-1318
    • Amouycl, P.A.1    Vidale, O.2    Launay, J.M.3    Laplanche, J.L.4
  • 33
    • 0028303072 scopus 로고
    • Apolipoprotein E: Structurc-function relationships
    • Weisgraber KH: Apolipoprotein E: Structurc-function relationships. AdvProtChem 1994;45:249-302.
    • (1994) Advprotchem , vol.45 , pp. 249-302
    • Weisgraber, K.H.1
  • 35
    • 0028173205 scopus 로고
    • Amyloid-associated proteins al-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer's p-protcin into filaments
    • Ma J, Yec A, Brewer HB, Das S, Potter H: Amyloid-associated proteins al-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer's p-protcin into filaments. Nature 1994;372:92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yec, A.2    Brewer, H.B.3    Das, S.4    Potter, H.5
  • 36
    • 0030045552 scopus 로고    scopus 로고
    • Properties of the cndosomal-lysosomal sytcm in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
    • Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA: Properties of the cndosomal-lysosomal sytcm in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Ncurosci 1996:16:186-199.
    • (1996) J Ncurosci , vol.16 , pp. 186-199
    • Cataldo, A.M.1    Hamilton, D.J.2    Barnett, J.L.3    Paskevich, P.A.4    Nixon, R.A.5
  • 38
    • 0023809230 scopus 로고
    • Alzheimer's disease: A double-labeling immunohistochemical study of senile plaques
    • Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH: Alzheimer's disease: A double-labeling immunohistochemical study of senile plaques. Am J Pathol 1988; 132: 86-101.
    • (1988) Am J Pathol , vol.132 , pp. 86-101
    • Dickson, D.W.1    Farlo, J.2    Davies, P.3    Crystal, H.4    Fuld, P.5    Yen, S.H.6
  • 39
    • 0019805463 scopus 로고
    • Fibrous astrocytes in senile dementia of the Alzheimer’s type
    • Schechter R, Yen SH, Terry RD: Fibrous astrocytes in senile dementia of the Alzheimer’s type. J Ncuropathol Exp Neurol 1981:40:95-101.
    • (1981) J Ncuropathol Exp Neurol , vol.40 , pp. 95-101
    • Schechter, R.1    Yen, S.H.2    Terry, R.D.3
  • 40
    • 0022517681 scopus 로고
    • Changing role of forebrain astrocytes during development, regenerative failure, and induced regeneration upon transplantation
    • Smith GM, Miller RH, Silver J: Changing role of forebrain astrocytes during development, regenerative failure, and induced regeneration upon transplantation. J Comp Neurol 1986;251:23-43.
    • (1986) J Comp Neurol , vol.251 , pp. 23-43
    • Smith, G.M.1    Miller, R.H.2    Silver, J.3
  • 42
    • 0028178458 scopus 로고
    • P-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C Iq A chain
    • Jiang H, Burdick D, Glabe CG, Cot-man CW, Tenner AJ: P-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C Iq A chain. J Immunol 1994:152:5050-5059.
    • (1994) J Immunol , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cot-Man, C.W.4    Tenner, A.J.5
  • 43
    • 0001360461 scopus 로고
    • Brain interleukin-1 and S-100 im-munoreactivity are elevated in Down’s syndrome and Alzheimer's disease
    • Griffin ST, Stanley LC, Ling C: Brain interleukin-1 and S-100 im-munoreactivity are elevated in Down’s syndrome and Alzheimer's disease. Proc Natl Acad Sci USA 1989;86:7611-7615.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7611-7615
    • Griffin, S.T.1    Stanley, L.C.2    Ling, C.3
  • 44
    • 0029161781 scopus 로고
    • Glial cytokines in Alzheimer's disease: Review and pathogenic implications
    • Mrak RE, Sheng JG, Griffin WS: Glial cytokines in Alzheimer's disease: Review and pathogenic implications. Human Pathol 1995:26: 816-823.
    • (1995) Human Pathol , vol.26 , pp. 816-823
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.3
  • 45
    • 0027468515 scopus 로고
    • Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells
    • Haga S, Ikcda K, Sato M, Ishii T: Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res 1993:601:88-94.
    • (1993) Brain Res , vol.601 , pp. 88-94
    • Haga, S.1    Ikcda, K.2    Sato, M.3    Ishii, T.4
  • 46
    • 0005775566 scopus 로고
    • Interleukin-1 regulates synthesis of amyloid p-protcin precursor mRNA in human endothelial cells
    • Goldgaber D, Harris HW, Hla T: Interleukin-1 regulates synthesis of amyloid p-protcin precursor mRNA in human endothelial cells. Proc Natl Acad Sci USA 1989:86:7606-7610.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7606-7610
    • Goldgaber, D.1    Harris, H.W.2    Hla, T.3
  • 47
    • 0027978247 scopus 로고
    • New opportunities in AD research: Roles of immunoinflammatory responses and glia
    • Frcdcrickson RCA, Brundcn KR: New opportunities in AD research: Roles of immunoinflammatory responses and glia. Alzheimer’s Dis Assoc Disord 1994:8:159-165.
    • (1994) Alzheimer’s Dis Assoc Disord , vol.8 , pp. 159-165
    • Frcdcrickson, R.1    Brundcn, K.R.2
  • 48
    • 0022803734 scopus 로고
    • Aluminum and Alzheimer's disease
    • Crapper Mclachlan DR: Aluminum and Alzheimer's disease. Neurobiol Aging 1986;7:525-532.
    • (1986) Neurobiol Aging , vol.7 , pp. 525-532
    • Crapper McLachlan, D.R.1
  • 50
  • 52
    • 1842377727 scopus 로고
    • Increased risk of dementia in mothers of Alzheimer’s disease cases: Evidence for maternal inheritance
    • poster 581.1. abstr
    • Edland SD, Silverman J, Peskind ER, Tsuang D, Wijsman E, Morris JC: increased risk of dementia in mothers of Alzheimer’s disease cases: Evidence for maternal inheritance. Soc Neurosci 1995;poster 581.1. abstr.
    • (1995) Soc Neurosci
    • Edland, S.D.1    Silverman, J.2    Peskind, E.R.3    Tsuang, D.4    Wijsman, E.5    Morris, J.C.6
  • 53
    • 0023882480 scopus 로고
    • Systemic manifestations of Alzheimer’s disease
    • Baker AC, Ko LW, Blass JP: Systemic manifestations of Alzheimer’s disease. Age 1988; 11:60-65.
    • (1988) Age , vol.11 , pp. 60-65
    • Baker, A.C.1    Ko, L.W.2    Blass, J.P.3
  • 54
    • 0029018851 scopus 로고
    • Secreted p-APP stimulates MAP kinase and phosphorylation of tau in neurons
    • Greenberg SM, Kosik KS: Secreted p-APP stimulates MAP kinase and phosphorylation of tau in neurons. Neurobiol Aging 1995;16:403-407.
    • (1995) Neurobiol Aging , vol.16 , pp. 403-407
    • Greenberg, S.M.1    Kosik, K.S.2
  • 55
    • 0022637266 scopus 로고
    • Lmmunocytochemical studies of ncurofilament antigens in the neurofibrillary pathology induced by aluminum
    • Troncoso JC, Sternberger NH, Stemberger LA, Hoffman PN, Price DL: lmmunocytochemical studies of ncurofilament antigens in the neurofibrillary pathology induced by aluminum. Brain Res 1986,364: 295-300.
    • (1986) Brain Res , vol.364 , pp. 295-300
    • Troncoso, J.C.1    Sternberger, N.H.2    Stemberger, L.A.3    Hoffman, P.N.4    Price, D.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.