Engineering protein mechanics: Inhibition of concerted motions of the cellular retinol binding protein by site-directed mutagenesis

Protein Engineering

Volumn 10, Issue 1, 1997, Pages 31-37

  Van Aalten, D M F ^a   Jones, P C ^a,c   De Sousa, M ^b   Findlay, J B C ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Cellular retinol binding protein; Essential dynamics; Molecular dynamics; Protein engineering; Site directed mutagenesis

Indexed keywords

CELLULAR RETINOL BINDING PROTEIN; GLYCINE; PROTEIN INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; GENETIC ENGINEERING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; VITAMIN METABOLISM;

EID: 0031019423     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.1.31     Document Type: Article

References (31)

1. Amadei, A., Linssen, A.B.M. and Berendsen, H.J.C. (1993) Proteins, 17, 412-425.
2. Berendsen, H.J.C., Postma, J.P.M., van Gunsteren, W.F. and Hermans, J. (1981) In Pullmann, B. (ed.), Intermolecular Forces. Reidel, Dordrecht, p. 331.
3. Cowan, C.W., Newcomer, M.E. and Jones, T.A. (1993) J. Mol. Biol., 230, 442-446.
4. Dayhoff, M.O., Schwarz, R.M. and Orcutt, B.C. (1978) In Dayhoff, M.O. (ed.), Atlas of Protein Sequence and Structure. National Biomedical Research Foundation, Washington, DC, p. 345.
5. Gekko, K., Yamagami, K., Kunori, Y., Ichibara, S., Kodama, M. and Iwakura, M. (1993) J. Biochem., 113, 74-80.
6. Gekko, K., Kunori, Y., Takeuchi, H., Ichibara, S. and Kodama, M. (1994) J. Biochem., 116, 34-41.
7. Gonnet, G.H., Cohen, M.A. and Benner, S.A. (1992) Science, 256, 1443-1445.
8. Heery, D.M., Gannon, F. and Powell, R. (1990) Trends Genet., 6, 173.
9. Herr, F.M. and Ong, D.E. (1992) Biochemistry, 31, 6748-6755.
10. Hopkins, P.C.R., Carell, R.W. and Stone, S.R. (1993) Biochemistry, 32, 7650-7657.
11. Inoue, H., Nojima, H. and Okayama, H. (1990) Gene, 96, 23-28.
12. Jamison, R.S., Newcomer, M.E. and Ong, D.E. (1994) Biochemistry, 33, 2873-2879.
13. Kabsch, W. and Sander, C. (1983) Biopolymers, 22, 2577-2637.
14. Landt, O., Grunert, H.P. and Hahn, U. (1990) Gene, 96, 125-128.
15. Levin, M.S., Locke, B., Yang, N.C., Li, E. and Gordon, J.I. (1988) J. Biol. Chem., 263, 17715-17723.
16. Li, E., Locke, B., Yang, N.C., Ong, D.E. and Gordon, J.I. (1987) Gastroenterology, 92, 1506.
17. N,R.G. and V,S. (1968) Adv. Protein Chem., 23, 283-437.
18. Peters, G.H., van Aalten, D.M.F., Edholm, O., Toxvaerd, S. and Bywater, R. (1996) Biophys. J., 71, 2245-2255.
19. Ryckaer, J.P., Ciccotti, G. and Berendsen, H.J.C. (1977) J. Comp. Phys., 23, 327-341.
20. Schagger, H. and von Jagow, G. (1987) Anal. Biochem., 166, 368-379.
21. Scheek, R.M., van Nuland, N.A.J., de Groot, B.L. and Amadei, A. (1995) J. Biomol. NMR, 6, 106-111.
22. Sivaprasadarao, A. and Findlay, J.B.C. (1993) Biochem. J., 296, 209-215.
23. Sivaprasadarao, A. and Findlay, J.B.C. (1994) Biochem. J., 300, 437-442.
24. Tanaka, T., Yamaguchi, H., Kato, H., Nishioka, T., Katsube, Y. and Oda, J. (1993) Biochemistry, 32, 12389-12404.
25. van Aalten, D.M.F., Amadei, A., Vriend, G., Linssen, A.B.M., Venema, G., Berendsen, H.J.C. and Eijsink, V.G.H. (1995) Proteins, 22, 45-54.
26. van Aalten, D.M.F., Amadei, A., Bywater, R., Findlay, J.B.C., Berendsen, H.J.C., Sander, C. and Stouten, P.F.W. (1996a) Biophys. J., 70, 684-692.
27. van Aalten, D.M.F., Findlay, J.B.C., Amadei, A. and Berendsen, H.J.C. (1996b) Protein Engng, 8, 1129-1135.
28. van Buuren, A.R., Marrink, S.J. and Berendsen, H.J.C. (1993) J. Phys. Chem., 97 (36), 9206-9212.
29. van Gunsteren, W.F. and Berendsen, H.J.C. (1987) GROMOS Manual. BIOMOS, Biomolecular Software, Laboratory of Physical Chemistry, University of Groningen, The Netherlands.
30. Vriend, G. (1990) J. Mol. Graph., 8, 52-56.
31. Zhang, J.H., Liu, Z.P., Jones, T.A., Gierasch, L.M. and Sambrook, J.F. (1992) Proteins, 13, 87-99.