Analysis of the candidate gene NRAMP1 in the first 61 ARC national repository families for rheumatoid arthritis

Journal of Rheumatology

Volumn 24, Issue 1, 1997, Pages 212-214

  Shaw, Marie Anne ^a,c   Clayton, David ^b   Blackwell, Jenefer M ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d Department of Molecular Parasitology ^*  (United Kingdom)

Author keywords

genetics; NRAMP1; rheumatoid arthritis; susceptibility gene

Indexed keywords

CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ALLELES; ARTHRITIS, RHEUMATOID; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENES; HAPLOTYPES; HLA ANTIGENS; HUMANS; MALE; MEMBRANE PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0031019261     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (22)

1. Blackwell JM, Roach TIA, Atkinson SE, et al: Genetic regulation of macrophage priming/activation: The Lsh gene story. Immunol Lett 1991;30:241-8.
2. Blackwell JM, Barton CH, White JK, et al: Genetic regulation of leishmanial and mycobacterial infections: The Lsh/Ity/Bcg gene story continues. Immunol Lett 1994;43:99-107.
3. Vidal SM, Malo D, Vogan K, Skamene E, Gros P: Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg. Cell 1993;73:469-85.
4. 2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain. J Exp Med 1994;179:1683-7.
5. Barton CH, Whitehead SH, Blackwell JM: Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: Influence on oxidative burst and nitric oxide pathways. Mol Med 1995;1:267-79.
6. Vidal S, Tremblay ML, Govoni G, et al: The Ity/Lsh/Bcg locus: Natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med 1995;182:655-66.
7. Blackwell JM, Barton CH, White JK, et al: Genomic organization and sequence of the human NRAMP gene: Identification and mapping of a promoter region polymorphism. Mol Med 1995;1:194-205.
8. White JK, Shaw M-A, Barton CH, et al: Genetic and physical mapping of 2q35 in the region of NRAMP and IL8R genes: Identification of a polymorphic repeat in exon 2 of NRAMP. Genomics 1994;24:295-302.
9. Shaw M-A, Clayton D, Atkinson SE, et al: Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J Med Genet 1996;33:672-7.
10. Worthington J, Ollier WER, Leach MK, et al: The Arthritis and Rheumatism Council's National Repository of family material: Pedigrees from the first 100 rheumatoid arthritis families containing affected sibling pairs. Br J Rheumatol 1994;33:970-6.
11. Haw EM, Ollier WER, Silman AJ: The Arthritis and Rheumatism Council's national family material repository. Br J Rheumatol 1993;32:443-4.
12. Risch N: Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990;46:229-41.
13. Risch N: Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 1990;46:242-53.
14. Holmans P: Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 1993;52:362-14.
15. Holmans P, Clayton D: Efficiency of typing unaffected relatives in an affected sib-pair linkage study with single locus and multiple tightly-linked markers. Am J Hum Genet 1993;51:1221-32.
16. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus. Am J Hum Genet 1993;52:506-16.
17. Schaid DJ, Sommer SS: Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 1994;55:402-9.
18. Deighton CM, Walker DJ, Griffiths ID, Roberts DF: The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36:178-82.
19. Rigby AS: HLA haplotype sharing in rheumatoid arthritis sibships: Risk estimates in siblings. Scand J Rheumatol 1992;21:68-73.
20. Risch N: Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987;40:1-14.
21. Copeman JB, Cucca C, Hearne CM, et al: Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 1995;9:80-5.
22. Risch N: Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-8.