Abnormal brain hemodynamic responses during passive orthostatic challenge in panic disorder

American Journal of Psychiatry

Volumn 154, Issue 3, 1997, Pages 378-383

  Faravelli, Carlo ^a,b   Marinoni, Marinella ^a   Spiti, Raffaello ^a   Ginanneschi, Andrea ^a   Serena, Andrea ^a   Fabbri, Cecilia ^a   Matteo, Cinzia Di ^a   Mastio, Monica Del ^a   Inzitari, Domenico ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANXIETY NEUROSIS; ARTICLE; AUTONOMIC DYSFUNCTION; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CLINICAL ARTICLE; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; FEMALE; HEMODYNAMIC MONITORING; HUMAN; MALE; MIDDLE CEREBRAL ARTERY; PANIC; PRIORITY JOURNAL; TILTING;

EID: 0031019226     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.3.378     Document Type: Article

References (52)

1. Reiman EM, Raichle ME, Butler FK, Herscovitch P, Robins E: A focal brain abnormality in panic disorder, a severe form of anxiety. Nature 1984; 310:683-685
2. Reiman EM, Raichle ME, Robins E, Butler FK, Herscovitch P, Fox P, Perlmutter J: The application of positron emission tomography to the study of panic disorder. Am J Psychiatry 1986; 143:469-477
3. Reiman EM, Raichle ME, Robins E, Mintun MA, Fusselman MJ, Fox PT, Price JL, Hackman KA: Neuroanatomical correlates of lactate-induced anxiety attack. Arch Gen Psychiatry 1989; 46:493-500
4. Stewart RS, Devous MD Sr, Rush AJ, Lane L, Bonte FJ: Cerebral blood flow changes during sodium-lactate-induced anic attacks. Am J Psychiatry 1988; 145:442-449
5. Nordhal TE, Semple WE, Gross M, Mellman TA, Stein MB, Coyer P, King AC, Uhde TW, Cohen RM: Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology 1990; 3:261-272
6. De Cristoforo MTR, Sessarego A, Pupi A, Biondi F, Faravelli C: Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study. Biol Psychiatry 1993; 33:505-512
7. Gibbs DM: Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine. Am J Psychiatry 1992; 149:1589-1591
8. Fontaine S, Ontiveros A Fontaine R, Elie R: Panic disorder: vascular evaluation with transcranial Doppler ultrasonography. Can Assoc Radiol J 1991; 42:412-416
9. Mathew RJ, Wilson WH: Anxiety and cerebral blood flow. Am J Psychiatry 1990; 147:838-849
10. Mathew RJ: Sympathetic control of cerebral circulation: relevance to psychiatry. Biol Psychiatry 1995; 37:283-285
11. Bishop CCR, Powell S, Rutt D, Browse NL: Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study. Stroke 1986; 17:913-915
12. Piepgras A, Schmiedek P, Leinsinger G, Haberl RL, Kirsch CM, Einhaeupl KM: A simple test to assess cerebrovascular reserve capacity using transcranial Doppler sonography and acetazolamide. Stroke 1990; 21:1306-1311
13. McLeod JG, Tuck RR: Disorders of the autonomie nervous system, part 2: investigation and treatment. Ann Neurol 1987; 21:519-529
14. Marinoni M, Ginanneschi A, Inzitari D, Mannelli M, Modesti PA, Amaducci L: Impaired cerebral autoregulation in patients with Shy-Drager syndrome. Int J Angiology 1993; 2(1):12-15
15. Daffertshofer M, Diehl RR, Ziems GU, Hennerici M: Orthostatic changes of cerebral blood flow velocity in patients with autonomie dysfunction. J Neurol Sci 1991; 104:32-38
16. Depresseux JC, Rousseau JJ, Franck G: The autoregulation of cerebral blood flow, the cerebrovascular reactivity and their interaction in the Shy-Drager syndrome. Eur Neurol 1979; 18:295-301
17. Briebach T, Laubenberger J, Fisher PA: Transcranial Doppler sonographic studies of cerebral autoregulation in Shy-Drager patients. J Neurol 1989; 236:349-350
18. Caronna JJ, Plum F: Cerebral regulation in preganglionic and postganglionic autonomic insufficiency. Stroke 1973; 4:12-19
19. Thomas DJ, Bannister R: Preservation of autoregulation of cerebral blood flow in autonomic failure. J Neurol Sci 1980; 44:205-212
20. Costello CG: Anxiety and the persisting novelty of input from the autonomic nervous system. Behavior Therapy 1971; 2:321-333
21. Holden AE, Barlow DH: Heart rate and heart rate variability recorded in vivo in agoraphobics and nonphobics. Behavior Therapy 1986; 17:26-42
22. Roth WT, Teleh MJ, Taylor CB, Sachitano JA, Gallen CC, Kopell ML, McClenahan KL, Agras WS, Pfefferbaum A: Autonomic characteristics of agoraphobia with panic attacks. Biol Psychiatry 1986; 21:1133-1154
23. Roth WT, Margraf J, Ehlers A, Taylor CB, Maddock RJ, Davies S, Agras S: Stress test reactivity in panic disorder. Arch Gen Psychiatry 1992; 49:301-310
24. Liebowitz MR, Gorman JM, Fyer AJ, Levitt M, Dillon D, Levy G, Appleby IL, Anderson S, Palij M, Davies SO, Klein DF: Lactate provocation of panic attacks, II: biochemical and physiological findings. Arch Gen Psychiatry 1985; 42:709-719
25. Stein MB, Trancer ME, Uhde TW: Heart rate and plasma norepinephrine responsivity to orthostatic challenge in anxiety disorders: comparison of patients with panic disorder and social phobia and normal control subjects. Arch Gen Psychiatry 1992; 49:311-317
26. Hoehn-Saric R, McLeod DR: The peripheral sympathetic nervous system: its role in pathological anxiety. Psychiatr Clin North Am 1988; 11:375-386
27. Charney DS, Heninger GR: Abnormal regulation of noradrenergic function in panic disorders. Arch Gen Psychiatry 1986; 43:1042-1054
28. Charney DS, Woods SW, Goodman WK, Heninger GR: Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks. Am J Psychiatry 1987; 144:1030-1036
29. Veith RC: Sympathetic nervous system function in depression and panic disorder, in Stress: Neurobiology and Neuroendocrinology. Edited by Brown MR, Koob GF, Rivier C, New York, Marcel Dekker, 1991, pp 395-436
30. George DT, Nutt DJ, Walker WV, Porges SW, Adinoff B, Linnoila M: Lactate and hyperventilation substantially attenuate vagal tone in normal volunteers. Arch Gen Psychiatry 1989; 46:153-156
31. Yeragani VK, Balon R, Pohl R, Ramesh C, Glitz D, Weinberg P, Merlos B: Decreased R-R variance in panic disorder patients. Acta Psychiatr Scand 1990; 81:554-559
32. Sartory G, Olajide D: Vagal innervation techniques in the treatment of panic disorder. Behav Res Ther 1988; 26:431-434
33. Maddock RJ, Carter CS, Magliozzi JR, Gietzen DW: Evidence that decreased function of lymphocyte βadrenoreceptors reflects regulatory and adaptive processes in panic disorder with agoraphobia. Am J Psychiatry 1993; 150:1219-1225
34. Brambilla F, Perna G, Garberi A, Nobile P, Bellodi L: Alpha 2adrenergic receptor sensitivity in panic disorder, I: GH response to GHRH and clonidine stimulation in panic disorder. Psychoneuroendocrinology 1995; 20:1-9
35. Brambilla F, Bellodi L, Arancio C, Nobile P, Perna G: Alpha 2adrenergic receptor sensitivity in panic disorder, II: cortisol response to clonidine stimulation in panic disorder. Psychoneuroendocrinology 1995; 20:11-19
36. Friedman BH, Thayer JF, Borkovec TD, Tyrrell RA, Johnson BH, Columbo R: Autonomic characteristics of nonclinical panic and blood phobia. Biol Psychiatry 1993; 34:298-310
37. Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, Srinivasan K, Weinberg P: Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res 1993; 46:89-103
38. Yeragani VK, Srinivasan K, Pohl R, Berger R, Balon R, Ramesh C: Effects of nortripryline on heart rate variability in panic disorder patients: a preliminary study using power spectral analysis of heart rate. Neuropsychobiology 1994; 29:1-7
39. Yeragani VK, Srinivasan K, Pohl R, Berger R, Balon R, Berchou R: Sodium lactate increases sympathovagal ratios in normal control subjects: spectral analysis of heart rate, blood pressure, and respiration. Psychiatry Res 1994; 54:97-114
40. Middleton HG, Ashby M: Clinical recovery from panic disorder is associated with evidence of changes in cardiovascular regulation. Acta Psychiatr Scand 1995; 91:108-113
41. Middleton HC, Ashby M, Robbins TW: Reduced plasma noradrenaline and abnormal heart rate variability in resting panic disorder patients. Biol Psychiatry 1994; 36:847-849
42. Klein E, Cnaani E, Harel T, Braun S, Ben-Haim SA: Altered heart rate variability in panic disorder patients. Biol Psychiatry 1995; 37:18-24
43. Stein MB, Asmundson GJG: Autonomic function in panic disorder: cardiorespiratory and plasma catecholamine responsivity to multiple challenges of the autonomic nervous system. Biol Psychiatry 1994; 36:548-558
44. Asmundson GJG, Stein MB: Vagal attenuation in panic disorder: an assessment of parasympathetic nervous system function and subjective reactivity to respiratory manipulations. Psychosom Med 1994; 56:187-193
45. Faravelli C, Paterniti S, Scarpato MA: 5-year prospective, naturalistic follow-up study of panic disorder. Compr Psychiatry 1995; 36:271-277
46. Endicott J, Spitzer RL: A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 1978; 35:837-844
47. Marks IM, Mathews AM: Brief standard self-rating scale for phobic patients, Behav Res Ther 1979; 17:263-267
48. Spielberger CD: Manual for the State-Trait Anxiety Inventory, revised ed. Palo Alto, Calif, Consulting Psychologists Press, 1983
49. Faravelli C, Paterniti S: The assessment of agoraphobic attitudes. Eur Psychiatry 1994; 9:223-228
50. Dillon DJ, German JM, Liebowitz MR, Fyer AJ, Klein DF: The measurement of lactate-induced panic and anxiety. Psychiatry Res 1987; 20:97-105
51. Aaslid R: Transcranial Doppier examination techniques, In Transcranial Doppler Sonography. Edited by Aaslid R. New York, Springer-Verlag, 1986, pp 39-50
52. Maeda H, Etani H, Handa N, Tagaya M, Oku N, Kim BH, Naka M, Kinoshita N, Nukada T, Fukunaga R: A validation study on the reproducibility of transcranial Doppler velocimetry. Ultrasound Med Biol 1990; 16:9-14