Recombinant staphylokinase variants with altered immunoreactivity: III: Species variability of antibody binding patterns

Circulation

Volumn 95, Issue 2, 1997, Pages 455-462

  Collen, Désiré ^a,b   De Cock, Frans ^a   Demarsin, Eddy ^a   Jenné, Stephane ^a   Lasters, Ignace ^a   Laroche, Yves ^a   Warmerdam, Petra ^a   Jespers, Laurent ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

infarction; plasminogen activators; thrombolysis

Indexed keywords

ALANINE; EPITOPE; FREUND ADJUVANT; MONOCLONAL ANTIBODY; RECOMBINANT ENZYME; STAPHYLOKINASE;

ACUTE HEART INFARCTION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BABOON; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ANTIGENICITY; ENZYME ACTIVITY; FIBRINOLYSIS; HAMSTER; HUMAN; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; RABBIT; SPECIES DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031018848     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.2.455     Document Type: Article

References (17)

1. Collen D, Zhao ZA, Holvoet P, Marijnen P. Primary structure and gene structure of staphylokinase. Fibrinolysis. 1992;6:226-231.
2. Collen D, Bernaerts R, Declerck P, De Cock F, Demarsin E, Jenné S, Laroche Y, Lijnen HR, Silence K, Verstreken M. Recombinant staphylokinase variants with altered immunoreactivity, I: construction and characterization. Circulation. 1996;94:197-206.
3. Collen D, Moreau H, Stockx L, Vanderschueren S. Recombinant staphylokinase variants with altered immunoreactivity, II: thrombolytic properties and antibody induction. Circulation. 1996;94:207-216.
4. Vanderschueren S, Stassen JM, Collen D. Comparative antigenicity of recombinant wild-type staphylokinase (SakSTAR) and a selected mutant (SakSTAR.M38) in a baboon thrombolysis model. J Cardiovasc Pharmacol. 1996;27:809-815.
5. Schlott B, Hartmann M, Gührs KH, Birch-Hirschfeld E, Pohl HD, Vanderschueren S, Van de Werf F, Michoel A, Collen D, Behnke D. High yield production and purification of recombinant staphylokinase for thrombolytic therapy. Biotechnology. 1994;12:185-189.
6. Silence K, Hartmann M, Gührs K-H, Gase A, Schlott B, Collen D, Lijnen HR. Structure-function relationships in staphylokinase as revealed by "clustered charge-to-alanine" mutagenesis. J Biol Chem. 1995;270:27192-27198.
7. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
8. Horton RM, Hunt HD, Ho SN, Pullen JK, Pease LR. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene. 1989;77:61-68.
9. Tartof KD, Hobbs CA. Improved media for growing plasmid and cosmid clones. Bethesda Res Lab Focus. 1987;9:12.
10. Jönsson U, Malmqvist M. Real time biospecific interaction analysis: the integration of surface plasmon resonance detection, general bio-specific interface chemistry and microfluidics into one analytical system. Adv Biosensors. 1992;2:291-336.
11. Johnsson B, Löfas S, Lindquist G. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal Biochem. 1991;198:268-277.
12. BIAcore System Manual, 5-2. Uppsala, Sweden: Pharmacia Biosensor AB.
13. Karlsson R, Michaelsson A, Mattsson L. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J Immunol Methods. 1991;145:229-240.
14. Collen D, Silence K, Demarsin E, De Mol M, Lijnen HR. Isolation and characterization of natural and recombinant staphylokinase. Fibrinolysis. 1992;6:203-213.
15. Collen D, Van de Werf F. Coronary thrombolysis with recombinant staphylokinase in patients with evolving myocardial infarction. Circulation. 1993;87:1850-1853.
16. Vanderschueren S, Barrios L, Kerdsinchai P, Van den Heuvel P, Hermans L, Vrolix M, De Man F, Benit E, Muyldermans L, Collen D, Van de Werf F. A randomized trial of recombinant staphylokinase versus alteplase for coronary artery patency in acute myocardial infarction. Circulation. 1995;92:2044-2049.
17. Collen D, Stockx L, Lacroix H, Suy R, Vanderschueren S. Recombinant staphylokinase variants with altered immunoreactivity, IV: identification of variants with reduced antibody induction but intact potency. Circulation. 1997;95:463-472.