Time course of hypoxic pulmonary vasoconstriction: A rabbit model of regional hypoxia

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 1, 1997, Pages 216-221

  Vejlstrup, Niels G ^a   O'Neill, Mark ^a   Nagyova, Beatrix ^a   Dorrington, Keith L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; HEART OUTPUT; HYPOXIA; LUNG ARTERIOVENOUS SHUNT; LUNG COLLAPSE; LUNG INFLATION; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; TIME;

EID: 0031018410     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.1.9001315     Document Type: Article

References (25)

1. Von Euler, U. S., and G. Liljestrand. 1946. Observations on the pulmonary arterial pressure in the cat. Acta Physiol. Scand. 12:301-320.
2. Domino, K. B., L. Chen, C. M. Alexander, J. J. Williams, C. Marshall, and B. E. Marshall. 1984. Time course and responses of sustained hypoxic pulmonary vasoconstriction in the dog. Anesthesiology 60:562-566.
3. Carlsson, A. J., L. Bindslev, J. Santesson, I. Gottlieb, and G. Hedenstierna. 1985. Hypoxic pulmonary vasoconstriction in the human lung: the effect of prolonged unilateral hypoxic challenge during anaesthesia. Acta Anaesthesiol. Scand. 29:346-351.
4. Cutaia, M., and S. Rounds. 1990. Hypoxic pulmonary vasoconstriction: physiologic significance, mechanism, and clinical relevance. Chest 97:706-718.
5. Glasser, S. A., K. B. Domino, L. Lindgren, P. Parcella, C. Marshall, and B. E. Marshall. 1983. Pulmonary blood pressure and flow during atelectasis in the dog. Anesthesiology 58:225-231.
6. Wahrenbrock, E. A., C. J. Carrico, D. A. Amundson, M. J. Trummer, and J. W. Severinghaus. 1970. Increased atelectatic pulmonary shunt during hemorrhagic shock in dogs. J. Appl. Physiol. 29:615-621.
7. Kersten, T. E., J. E. Mayer, R. L. Varco, and E. W. Humpfrey. 1977. The nature of failure of pulmonary adaptation to atelectasis. Surgery 82:90-98.
8. Fiser, W. P., C. D. Friday, and R. C. Read. 1979. Pulmonary circulatory adaptation to acute atelectasis in man. Tex. Rep. Biol. Med. 39: 235-245.
9. Leach, R. M., T. P. Robertson, C. H. C. Twort, and J. P. T. Ward. 1994. Hypoxic constriction in rat pulmonary and mesenteric arteries. Am. J. Physiol. 266:L223-L231.
10. Welling, K. K., R. Sanchez, J. B. Ravn, B. Larsen, and O. Amtorp. 1993. Effect of prolonged alveolar hypoxia and pulmonary arterial pressure and segmental vascular resistance. J. Appl. Physiol. 75:1194-1200.
11. Weissmann, N., F. Grimminger, D. Walmrath, and W. Seeger. 1995. Features of hypoxic pulmonary vasoconstriction in buffer-perfused rabbit lungs. Respir. Physiol. 100:159-169.
12. Raffestin, B., and I. F. McMurtry. 1987. Effects of intracellular pH on hypoxic vasoconstriction in rat lungs. J. Appl. Physiol. 63:2524-2531.
13. von Neergaard, K. 1929. Neue Auffassungen über einen Grundbegriff der Atemmechanik. Z. Ges. Exp. Med. 66:373-394.
14. Nunn, J. F. 1993. Nunn's Applied Respiratory Physiology, 4th ed. Butterworth-Heinemann, Oxford, England. 178-179, 195-197.
15. 2-Hb affinity of rabbit and cat blood. Pflüger's Arch. 408:451-457.
16. Quebbeman, E. J., and C. A. Dawson. 1976. Influence of inflation and atelectasis on the hypoxic pressor response in isolated dog lung lobes. Cardiovasc. Res. 10:672-677.
17. Enjeti, S., P. B. Terry, H. A. Menkes, and R. J. Traystman. 1987. Mechanical factors and the regulation of perfusion through atelectatic lung in pigs. J. Appl. Physiol. 52:647-654.
18. Vejlstrup, N. G., C. A. R. Boyd, and K. L. Dorrington. 1994. Effect of lung inflation on active and passive liquid clearance from in vivo rabbit lung. Am. J. Physiol. 267:L482-L487.
19. Dorrington, K. L., and C. A. R. Boyd. 1995. Active transport in the alveolar epithelium of the adult lung: vestigial or vital? Respir. Physiol. 100:177-183.
20. Dorrington, K. L. 1980. The theory of viscoelasticity in biomaterials. In J. F. V. Vincent and J. D. Curry, editors. The Mechancial Properties of Biological Materials: Society for Experimental Biology Symposium XXIV. Cambridge University Press, Cambridge, UK. 289-314.
21. Fredén, F., I. Cigarini, F. Mannting, A. Hagberg, F. Lemaire, and G. Hedenstierna. 1993. Dependence of shunt on cardiac output in unilobar oleic acid edema. Distribution of ventilation and perfusion, Intens. Care Med. 19:185-190.
22. Marshall, C., L. Lindgren, and B. E. Marshall. 1984. Effects of halothane, enflurane, and isoflurane on hypoxic pulmonary vasoconstriction in rat lungs in vitro. Anesthesiology 60:304-308.
23. Vejlstrup, N. G., and K. L. Dorrington. 1993. Intense slow hypoxic pulmonary vasoconstriction in gas-filled and liquid-filled lungs: in in vivo study in the rabbit. Acta Physiol. Scand. 148:305-313.
24. Dirken, M. N. J., and H. Heemstra. 1948. Alveolar oxygen tension and lung circulation. Q. J. Exp. Physiol. 34:193-211.
25. Howard, L. S. G. E., and P. A. Robbins. 1995. Ventilatory response to 8 h of isocapnic and poikilocapnic hypoxia in humans. J. Appl. Physiol. 78:1092-1097.