Renal denervation altered the hemodynamic and renal effects following intracerebroventricular administration of the I1-imidazoline receptor agonist, rilmenidine, in pentobarbital anaesthetized rats

Neurochemistry International

Volumn 30, Issue 1, 1997, Pages 55-62

  Penner, S Brian ^a   Smyth, Donald D ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOBARBITAL; RILMENIDINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; FREE WATER CLEARANCE; HEART RATE; HEMODYNAMICS; KIDNEY BLOOD FLOW; KIDNEY DENERVATION; KIDNEY NERVE; NONHUMAN; OSMOTIC DIURESIS; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; URINE FLOW RATE;

ANESTHESIA; ANIMALS; BLOOD PRESSURE; DENERVATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAVENTRICULAR; KIDNEY; NATRIURESIS; OSMOLAR CONCENTRATION; OXAZOLES; PENTOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG;

EID: 0031018103     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00038-1     Document Type: Article

References (23)

1. Allan, D. R., Penner, S. B. and Smyth, D. D. (1993) Renal imidazoline preferring sites and solute excretion in the rat. Br. J. Pharmacol. 108, 870-875.
2. Blandford, D. E. and Smyth, D. D. (1988) Dose selective dissociation of water and solute excretion after alpha-2 adrenoceptor stimulation. J. Pharmacol. Exp. Ther. 247, 1181-1186.
3. Bousquet, P., Feldman, J. and Schartz, J. (1984) Central cardiovascular effects of the alpha adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230, 232-236.
4. Coupry, I., Atlas, D., Podevin, R.-A., Uzielli, I. and Parini, A. (1989) Imidazoline-guanidinium receptive site in renal proximal tubule: Asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance. J. Pharmacol. Exp. Ther. 252, 293-299.
5. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
6. 1-imidazoline receptors. J. Cardiovasc. Pharmacol. 20(4), S1-S10.
7. Ernsberger, P., Damon, T. H., Graff, L. M., Schäfer, S. G. and Christen, M. O. (1993) Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for Il-imidazoline sites. J. Pharmacol. Exp. Ther. 264, 172-182.
8. Fortin, T. L. and Sundaresan, P. R. (1989) Reserpine but not surgical denervation regulates rat renal α-adrenergic receptors. Am. J. Physiol. 256, F532-F539.
9. Gomez, R. E., Ernsberger, P., Feinland, G. and Reis, D. J. (1991) Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol. 195, 181-191.
10. Greenberg, S. G., Enders, C. and Osborn, J. L. (1993) Renal nerves affect rate of achieving sodium balance in spontaneously hypertensive rats. Hypertension 22, 1-8.
11. 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system. Br. J. Pharmacol. 109, 831-837.
12. Kline, R. L. and Cechetto, D. F. (1993) Renal effects of rilmenidine in anesthetized rats: importance of the renal nerves. J. Pharmacol. Exp. Ther. 266, 1556-1562.
13. Koepke, J. P., Jones, S. and DiBona, G. F. (1987) Alpha-2 adrenoceptors in amygdala control renal sympathetic nerve activity and renal function in conscious spontaneously hypertensive rats. Brain Res. 404, 80-88.
14. Kopp, U.C. and DiBona, G. F. (1992) The neural control of renal function. In The Kidney - Physiology and Pathophysiology (Seldin, D.W. and Giebisch, G., Eds), pp. 1157-1204. Raven Press, New York.
15. Michel, M. C. and Insel, P. A. (1989) Are there multiple imidazoline binding sites?. Trends Pharmacol. Sci. 10, 342-344.
16. Penner, S. B. and Smyth, D. D. (1988) Chronic prazosin attenuates the natriuretic response to a modest saline load in rats. Br. J. Pharmacol. 93, 446-452.
17. Penner, S. B., Smyth, D. D. and Glavin, G. B. (1990) Decreased gastric acid output following neuropeptide Y administration into the lateral cerebral ventricle of conscious rats. Ann. N. Y. Acad. Sci. 597, 43-50.
18. 1 imidazoline receptor agonist, moxonidine. Br. J. Pharmacol. 112, 1089-1094.
19. 1-imidazoline agonist, moxonidine. Br. J. Pharmacol. 116, 2631-2636.
20. Penner, S. B. and Smyth, D. D. (1995b) Rilmenidine alters renal function when administered intracerebroventicular or intrarenal. Ann. N.Y. Acad. Sci. 763, 353-356.
21. Sannajust, F., Barres, C., Koenig-Bérard, E. and Sassard, J. (1992) Sympathoinhibitory effects of rilmenidine may be mediated by sites located below the brainstem. Br. J. Pharmacol. 105, 535-541.
22. Smyth, D. D., Li, P., Blandford, D. E. and Penner, S. B. (1992) Opposite rank order of potency for alpha-2 adrenoceptor agonists on water and solute excretion in the rat: Two sites and/or receptors? J. Pharmacol. Exp. Ther. 261, 1080-1086.
23. Winer, B. J. (1971). Statistical Principles in Experimental Design, 2nd edn. McGraw-Hill, New York.