Nramp1 transfection transfers Ity/Ish/Bcg-related pleiotropic effects on macrophage activation: Influence on antigen processing and presentation

Infection and Immunity

Volumn 65, Issue 2, 1997, Pages 380-386

  Lang, Thierry ^a   Prina, Eric ^a   Sibthorpe, Dean ^b   Blackwell, Jenefer M ^b  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLELE; ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; DISEASE PREDISPOSITION; GENETIC TRANSFECTION; LONG TERMINAL REPEAT; MACROPHAGE ACTIVATION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; RAT; T LYMPHOCYTE;

EID: 0031017527     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.2.380-386.1997     Document Type: Article

References (35)

1. Antoine, J.-C., C. Jouanne, T. Lang, E. Prina, C. de Chastellier, and C. Frehel. 1996. Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis. Infect. Immun. 59:764-775.
2. Barton, C. H., S. H. Whitehead, and J. M. Blackwell. 1995. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways. Mol. Med. 1:267-279.
3. Bhattacharya, A., M. E. Dorf, and T. A. Springer. 1981. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127:2488-2495.
4. Blackwell, J. M. 1989. The macrophage resistance gene Lsh/Ity/Bcg. Res. Immunol. 140:767-828.
5. Blackwell, J. M., C. H. Barton, J. K. White, T. I. A. Roach, M.-A. Shaw, S. H. Whitehead. B. A. Mock, S. Searle, H. Williams, and A.-M. Baker. 1994. Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/ Beg gene story continues. Immunol. Lett. 43:99-107.
6. Blackwell, J. M. 1996. Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility. Mol. Med. Today 2:205-211.
7. Cellier, M., A. Belouchi and P. Gros. 1996. Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet. 12:201-204.
8. Denzin, L. K., N. F. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen processing defect in T2 cells. Immunity 1:1-20.
9. Goldstein, P., C. Goridis, C., A.-H. Schmitt-Verholst, B. Hayot, A. Pierres, A. Van Agthoven, Y. Kaufman, and Z. Eshhaz. 1982. Lymphoid cell surface interaction structures detected using cytolysis-inhibited monoclonal antibodies. Immunol. Rev. 68:5-42.
10. Gly169 allele. Infect. Immun. 64: 2923-2929.
11. Kaye, P. M., and J. M. Blackwell. 1989. Lsh, antigen presentation and the development of CMI. Res. Immunol. 140:810-815.
12. Kaye, P. M., N. K. Patel, and J. M. Blackwell. 1988. Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function. Immunology. 65:17-22.
13. Kramnik, I., D. Radzioch, and E. Skamene. 1994. T-helper 1-like subset selection in Mycobacterium bovis bacillus Calmette-Guérin-infected resistant and susceptible mice. Immunology 81:618-625.
14. Lang, T., R. Hellio, P. M. Kaye, and J. Antoine. 1994. Leishmania donovani-infected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation. J. Cell Sci. 107:2137-2150.
15. Mellins, E., L. Smith, B. Arp, T. Cotner, E. Celis, and D. Pious. 1990. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71-74.
16. Monaco, J. J., and D. Nandi. 1995. The genetics of proteasomes and antigen processing. Annu. Rev. Genet. 29:729-754.
17. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563-566.
18. Penninger, J. M., T. Wen, E. Timms, J. Potter, V. A. Wallace, T. Matsuyama, D. Ferrick, B. Sydora, M. Kronenberg, and T. W. Mak. 1995. Spontaneous resistance to actute T-cell leukemias in TCRVg1.1Jg4Cg4 transgenic mice. Nature 375:241-244.
19. Prina, E., C. Jouanne, S. de Souza Leao, A. Szabo, J.-G. Guillet, and J.-C. Antoine. 1993. Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes. J. Immunol. 151:2050-2061.
20. Prina, E., T. Lang, N. Glaichenhaus, and J. Antoine. Presentation of protective parasite antigen LACK of Leishmania-infected macrophages. J. Immunol., in press.
21. Radzioch, D., T. Hudson, M. Boule, L. Barrera, J. W. Urbance, L. Varieso, and E. Skamene. 1991. Genetic resistance/susceptibility to Mycobacterium: phenotypic expression in bone marrow-derived macrophage lines. J. Leukocyte Biol. 50:263-270.
22. Radzioch, D., I. Kramnik, and E. Skamene. 1995. Molecular mechanisms of natural resistance to mycobacterial infections. Circ. Shock 44:115-120.
23. Rouas, N., S. Christophe, F. Housseau, D. Bellet, J.-G. Guillet, and J.-M. Bidart. 1993. Influence of protein-quaternary structure of antigen processing. J. Immunol. 150:782-792.
24. Sanderson, F., M. M. Kleijmeer, A. Kelly, D. Verwoerd, A. Tulp, et al. 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266:1566-1569.
25. Scott, P., P. Caspar, and A. Sher. 1990. Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes. J. Immunol. 144:1075-1079.
26. Searle, S., N. Bright, P. Atkinson, C. H. Barton, and J. M. Blackwell. Unpublished data.
27. Shaw, M., D. Clayton, S. E. Atkinson, H. Williams, N. Miller, D. Sibthorpe, and J. M. Blackwell. 1996. Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J. Med. Genet. 33:672-677.
28. Shimonkevitz, R., J. Kappler, P. Marrack, and H. Grey. 1984. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067-2074.
29. Skamene, E. 1994. The Bcg gene story. Immunobiology 191:451-460.
30. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, et al. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802-806.
31. Supeck, F., L. Supekova, H. Nelson, and N. Nelson. 1996. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. Natl. Acad. Sci. USA 93:5105-5110.
32. Vidal, S., M. L. Tremblay, G. Govoni, S. Gauthier, G. Sebastiani, D. Malo, E. Skamene, M. Olivier, S. Jothy, and P. Gros. 1995. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182:655-666.
33. West, A. H., D. J. Clark, J. Martin, W. Neupert, F. U. Hartl, and A. L. Horwich. 1992. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J. Biol. Chem. 267:24625-24633.
34. Zaller, S. M., and V. Sloan. 1995. The role of DM molecules in antigen presentation. FASEB J. 9:A1026.
35. Zwilling, B. S., L. Vespa, and M. Massie. 1987. Regulation of I-A expression by murine peritoneal macrophages: differences linked to the Bcg gene. J. Immunol. 138:1372-1376.