In-vitro stability of porcine factor VIII (Hyate:C®)

Haemophilia

Volumn 3, Issue 1, 1997, Pages 21-23

  Woloschuk, D M M ^a   Rubinger, M ^b   Israels, S J ^b   Houston, D S ^b   Schwetz, N ^b   Johnston, J B ^b  

^a HEALTH SCIENCES CENTRE   (Canada)

^b NONE

Author keywords

Continuous infusion; Factor VIII replacement; Incompatibility; Stability

Indexed keywords

BLOOD CLOTTING FACTOR 8 CONCENTRATE; SODIUM CHLORIDE;

ARTICLE; BODY TEMPERATURE; DRUG ACTIVITY; DRUG STABILITY; DRUG STORAGE; ENVIRONMENTAL TEMPERATURE; HEMOPHILIA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIGHT; PRIORITY JOURNAL; SAMPLE; SWINE; SYRINGE; TIME;

EID: 0031017434     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.1997.00084.x     Document Type: Article

References (9)

1. Martinowitz U, Schulman S, Gitel S, Horoszowski H, Heim M, Varon D. Adjusted dose continuous infusion of Factor VIII in patients with haemophilia A. Br J Haemat 1992; 82: 729-34.
2. Bona RD, Riberio M, Klatsky AU, Panek S, Magnifico M, Rickles FR. Continuous infusion of porcine factor VIII for the treatment of patients with Factor VIII inhibitors. Sem Hematol 1993; 30 (Suppl 1): 32-5.
3. Martinowitz U, Schulman S. Continuous infusion of coagulation products, Int J Ped Hemat Oncol 1994; 1: 471-8.
4. Gordon EM, Al-Batniji F, Goldsmith JC. Continuous infusion of monoclonal antibody-purified factor VIII: rational approach to serious hemorrhage in patients with allo-/ autoantibodies to factor VIII. Amer J Hemat 1994; 45: 142-5.
5. Schulman S, Gitel S, Martinowitz U. Stability of factor VIII concentrates after reconstitution. Amer J Hemat 1994; 45: 217-23.
6. Porton Speywood Limited. Hyate:C Porcine Factor VIII:C® product insert, May 1990.
7. Stella VJ. Chemical and physical bases determining the instability and incompatibility of formulated injectable drugs. J Parenter Sci Technol 1986; 40: 142-63.
8. Kernoff PBA. Rationale and evolution of therapy with porcine factor VIII.C. Amer J Med 1991; 91 (Suppl 5A): 20S-22S.
9. Moore JW, Pearson RG. Kinetics and Mechanisms: a Study of Homogeneous Chemical Reactions, 3rd edn. New York, NY: John Wiley & Sons, 1981; 31-36, 83-191.