Modulation of procainamide's effect on conduction by cellular uncoupling in perfused rabbit hearts

Journal of Cardiovascular Electrophysiology

Volumn 8, Issue 2, 1997, Pages 199-214

  Spear, Joseph F ^a   Hook, Bruce G ^b   Josephson, Mark E ^b   Moore, E Neil ^b  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^b NONE

Author keywords

activation sequence maps; anisotropic conduction; gap junctions; intracellular potentials; myocardial anisotropy

Indexed keywords

PROCAINAMIDE;

ANIMAL TISSUE; ANISOTROPY; ARTICLE; CELL JUNCTION; DRUG EFFECT; FEMALE; HEART ARRHYTHMIA; HEART INNERVATION; HEART PERFUSION; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0031017196     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1997.tb00781.x     Document Type: Article

References (40)

1. Working Group Arrhythmia European Society Cardiology: The Sicilian Gambit: A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Circulation 1991;84:1831-1851.
2. Herzberg EL, Johnson RG: Gap junctions. In Satir B, ed: Modern Cell Biology, Volume 7. Alan R. Liss, New York, 1988.
3. Saffitz JE, Davis LM, Darrow BJ, et al: The molecular basis of anisotropy: Role of gap junctions. J Cardiovasc Electrophysiol 1995;6:498-510.
4. Lesh MD, Spear JF, Moore EN: The importance of cell coupling and anisotropy to conduction in cardiac tissue. In: Current Topics in Cardiology: 1991, Elsevier Science Publishing Co., New York, 1991, pp. 25-34.
5. Lesh MD, Spear JF, Moore EN: Myocardial anisotropy: Basic electrophysiology and role in cardiac arrhythmias. In Zipes DP, Jalife J, eds: Cardiac Electrophysiology:- From Cell to Bedside. WB Saunders Co., Philadelphia, 1990, pp. 364-376.
6. Spach MS, Dolber PC, Heidlage JF: Properties of discontinuous anisotropic propagation at a microscopic level. Ann NY Acad Sci 1990;591:62-74.
7. Spach MS, Dolber PC: Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle: Evidence for electrical uncoupling of side to side fiber connections with increasing age. Circ Res 1986;58:356-371.
8. Joyner RW, Overholt ED: Effects of octanol on canine subendocardial Purkinje-to-ventricular transmission. Am J Physiol 1985;249:C447-C455.
9. Wit AL, Dillon SM, Coromilas J, et al: Anisotropic reentry in the epicardial border zone of myocardial infarcts. Ann NY Acad Sci 1990;591:86-108.
10. Kieval RS, Spear JF, Moore EN: Mechanisms of arrhythmias and basis of antiarrhythmic drug action: The role of cell coupling. In Horowitz LN, ed: Current Management of Arrhythmias. BC Decker, Inc., Philadelphia, 1990, pp. 1-10.
11. Burt JM, Spray DC: Inotropic agents modulate gap junctional conductance between cardiac myocytes. Am J Physiol 1988;254:H1206-H1210.
12. Burt JM, Massey KD, Minnich BN: Uncoupling of cardiac cells by fatty acids: Structure-activity relationships. Am J Physiol 1991;260(Cell Physiol):C439-C448.
13. Burt JM, Spray DC: Volatile anesthetics block intercellular communication between neonatal rat myocardial cells. Circ Res 1989;65:829-837.
14. Kieval RS, Spear JF, Moore EN: Gap junctional conductance in ventricular myocyte pairs isolated from postischemic rabbit myocardium. Circ Res 1992;71: 127-136.
15. Rudisuli A, Weingart R: Electrical properties of gap junction channels in guinea-pig ventricular cell pairs revealed be exposure to heptanol. Pfl̈gers Arch 1989;415:12-21.
16. ++. J Gen Physiol 1990;95:1061-1075.
17. Balke CW, Lesh MD, Spear JF, et al: Effects of cellular uncoupling on conduction in anisotropic canine ventricular myocardium. Circ Res 1988;63:879-892.
18. Brugada J, Mont L, Boersma L, et al: Differential effects of heptanol, potassium, and tetrodotoxin on reentrant ventricular tachycardia around a fixed obstacle in anisotropic myocardium. Circulation 1991;84:1307-1318.
19. + concentration and stimulation frequency. Jpn Circ J 1985;49:487-498.
20. Anderson KP, Walker R, Lux RL, et al: Conduction velocity depression and drug induced ventricular tachyarrhythmias effects of lidocaine in the intact canine heart. Circulation 1990;81:1024-1038.
21. Turgeon J, Wisialowski TA, Wong W, et al: Suppression of longitudinal versus transverse conduction by sodium channel block effects of sodium bolus. Circulation 1992;85:2221-2226.
22. Spach MS, Dolber PC, Heidlage JF: Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ Res 1988;62:811-832.
23. Kadish AH, Spear JF, Levine JH, et al: The effects of procainamide on conduction in anisotropic canine ventricular myocardium. Circulation 1986;74:616-625.
24. Delmar M, Michaels DC, Johnson T, et al: Effects of increasing intracellular resistance on transverse and longitudinal propagation in sheep epicardial muscle. Circ Res 1987;60:780-785.
25. Nelson WL, Makielski JC: Block of sodium current by heptanol in voltage-clamped canine cardiac Purkinje cells. Circ Res 1991;68:977-983.
26. Oxford GS, Swenson RP: n-Alkanols potentiate sodium channel inactivation in squid giant axons. Biophys J 1979;26:585-590.
27. Grant AO, Starmer CF, Strauss HC: Antiarrhythmic drug action: Blockade of the inward sodium current. Circ Res 1984;55:427-439.
28. Nassif G, Dillon SM, Rayhill S, et al: Reentrant circuits and the effects of heptanol in a rabbit model of infarction with a uniform anisotropic epicardial border zone. J Cardiovase Electrophysiol 1993;4:112-133.
29. Spach MS, Kootsey JM, Sloan JD: Active modulation of electrical coupling between cardiac cells of the dog. A mechanism for transient and steady state variations in conduction velocity. Circ Res 1982;51:347-362.
30. Callans DJ, Kieval RS, Hook BG, et al: The effect of coronary perfusion of heptanol or potassium on conduction and ventricular arrhythmias. Am J Physiol 1992;263:H1382-H1389.
31. Rosen MR, Merker C, Gelband H, et al: Effects of procaine amide on the electrophysiological properties of the canine ventricular conducting system. J Pharmacol Exp Ther 1973;185:438-446.
32. Sugiura H, Joyner RW: Action potential conduction between guinea pig ventricular cells can be modulated by calcium current. Am J Physiol 1992;263:H1591-H1604.
33. Spach MS: The discontinuous nature of electrical propagation in cardiac muscle: Consideration of a quantitative model incorporating the membrane ionic properties and structural complexities. Ann Biomed Eng 1983;2:209-261.
34. Spach MS, Kootsey JM: Relating the sodium current and conductance to the shape of transmembrane and extracellular potentials by simulation: Effects of propagation boundaries. IEEE Trans Biomed Eng 1985;32: 743-755.
35. de Langen CDJ, Hanich RF, Michelson EL, et al: Differential effects of procainamide, lidocaine and acetylstrophanthidin on body surface potentials and epicardial conduction in dogs with chronic myocardial infarction. J Am Coll Cardiol 1988;11:403-413.
36. Freedman RA, Steinberg JS: Selective prolongation of QRS late potentials by sodium channel blocking antiarrhythmic drugs: Relation to slowing of ventricular tachycardia. J Am Coll Cardiol 1991;17:1017-1025.
37. Schmidtt CG, Kadish AH, Marchlinski FE, et al: Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm. Circulation 1988;77:1030-1037.
38. de Bakker JMT, van Capelle FJL, Janse MJ, et al: Slow conduction in the infarcted human heart: "Zigzag" course of activation. Circulation 1993;88: 915-926.
39. Gardner PI, Ursell PC, Fenoglio JJ, et al: Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation 1985;72:596-611.
40. Jalife J, Sicouri S, Delmar M, et al: Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers. Am J Physiol 1989;257:H179-H189.