Characterization of a SV40-transformed rheumatoid synovial fibroblast cell line which retains genotypic expression patterns: A model for evaluation of anti-arthritic agents

In Vitro Cellular and Developmental Biology - Animal

Volumn 33, Issue 1, 1997, Pages 37-41

  Zhang, Huanc G E ^a,b   Blackburn Jr , Warren D ^a,b   Minghetti, Phillip P ^a,b  

^a and Clinical Center   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

cytokines; dexamethasone; disease model; metalloproteinases; PMA

Indexed keywords

ANTIBODY SPECIFICITY; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL TRANSFORMATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENE THERAPY; HUMAN; HUMAN TISSUE; RHEUMATOID ARTHRITIS; SIMIAN VIRUS 40; SYNOVIUM; TRANSCRIPTION REGULATION;

EID: 0031017159     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-997-0020-7     Document Type: Article

References (27)

1. Angel, P.; Baumann, I.; Stein, B., et al. 12-O-Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer located in the 5′-flanking region. Mol. Cell Biol. 7:2256-2266; 1987a.
2. Angel, P.; Imagawa, M.; Chiu, R., et al. Phorbol ester inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739; 1987b.
3. Angel, P.; Allegretto, E. A.; Okino, S. T., et al. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332:166-171; 1988a.
4. Angel, P.; Hattori, K.; Smeal, T., et al. The jun proto-oncogene is positively autoregulated by its product, jun/AP1. Cell 55:875-885; 1988b.
5. Angel, P.; Karin, M. Specific members of the jun protein family regulate collagenase expression in response to various extracellular stimuli. Matrix 1:156-164; 1992.
6. Arend, W. P. Growth factors and cytokines in the rheumatoid diseases. In Schumacher, H. R.; Klippel, J. H.; Koopman, W. J., ed. Primer on the rheumatic diseases. 10th ed. Arthritis Foundation, Atlanta, GA; 1993:46-49.
7. Ausubel, F. M.; Brent, R.; Kingston, R. E., et al. Analysis of RNA by Northern and slot blot hybridization. In: Current protocols in molecular biology. Vol. 1. New York: John Wiley & Sons, Inc.; 1994:4.9.1-4.9.12.
8. Brinckerhoff, C. E.; Plucinska, I. M.; Sheldon, R. A., et al. Half life of synovial cell collagenase mRNA is modulated by phorbol myrislate acate but not by all-trans-retinoic acid or dexamethasone. Biochemistry 25:6378-6384; 1986.
9. Bohmann, D.; Bos, T. J.; Admon, A., et al. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238:1386-1392; 1987.
10. Croston, G. E.; Cao, Z.; Goeddel, D. V. NF-kβ activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J. Biological Chemistry 270:16514-16517; 1995.
11. Daver, J. M.; Krane, S. M.; Russell, R. G. G., et al. Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc. Natl. Acad. Sci. USA 73:945-949; 1976.
12. Doren, K. V.; Gluzman, Y. Efficient transformation of human fibroblasts by adenovirus-simian virus 40 recombinants. Mol. Cell. Biol. 14:1653-1656; 1984.
13. Goldring, M. B.; Birkhead, J. R.; Suen, L.-F., et al. Interleukin-1β-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest. 94:2307-2316; 1994.
14. Goto, M.; Sasano, M.; Yamanaka, H., et al. Spontaneous production of an interleukin-1-like factor by cloned rheumatoid synovial cells in long-term culture. J. Clin. Invest. 80:786-796; 1987.
15. Halazonetis, T. D.; Georgopoulos, K.; Greenberg, M. E., et al. C-jun dimerizes with itself and with c-fos, forming complexes of different DNA binding affinities. Cell 55:917-924; 1988.
16. Heck, S.; Kullmann, M.; Gast, A., et al. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13:4087-4095; 1994.
17. Imai, S.-I.; Takano, T. Loss of collagenase gene expression in immortalized clones of SV40 T-antigen-transformed human diploid fibroblasts. Biochem. Biophys. Res. Comm. 189:148-153; 1992.
18. Koopman, W. J.; Schrohenloher, R. E. Rheumatoid factor, rheumatoid arthritis, etiology, diagnosis and therapy. In: Utsinger, P. D.; Zvaifler, N. J.; Ehrlich, G. E., ed. Philadelphia: J. B. Lippincott Co.; 1985:214-241.
19. Lafyatis, R.; Kim, S. J.; Angel, P., et al. Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5′ activator protein-1 binding site. Mol. Endocrinol. 4:973-980; 1990.
20. Lemarire, R.; Flipo, R.-M.; Monte, D., et al. Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits RA transient tumor formation in immunodeficient mice. J. Rheum. 21:1409-1419; 1994.
21. Okada, Y.; Takeuchi, N.; Gonoji, Y., et al. Simultaneous production of collagenase, matrix metalloproteinase 3 (stromelysin) and tissue inhibitor of metalloproteinases by rheumatoid synovial lining cells. Matrix 1:398-399; 1992.
22. Schindler, R.; Gelfand, J. A.; Dinarello, C. A. Recombinant C5a stimulates transcription rather than translation of IL-1 and TNF: priming of mononuclear cells with recombinant C5a enhances cytokine synthesis induced by LPS, IL-1 or PMA. Blood 76:1631; 1990.
23. Singer, K. H.; Scearce, R. M.; Tuck, D. T., et al. Removal of fibroblasts from human epithelial cell cultures with use of a complement fixing monoclonal antibody reactive with human fibroblasts and monocytes/macrophages. J. Invest. Dermatol. 92:166-170; 1989.
24. Takashiba, S.; Shapira, L.; Amar, S., et al. Cloning and characterization of human TNF-α promoter region. Gene 131:307-308; 1993.
25. Thenet, S.; Benya, P. D.; Demignot, S., et al. SV40 immortalization of rabbit articular chondrocytes: alteration of differentiated functions. J. Cell. Physiol. 150:158-167; 1992.
26. Werb, Z.; Huttenlocher, A. Proteinases and their inhibitors. In: Schumacher, H. R.; Klippel, J. H.; Koopman, W. J., ed. Primer on the rheumatic diseases. 10th ed. Arthritis Foundation, Atlanta, GA; 1993:52-56.
27. Wilder, R. L. Rheumatoid arthritis, epidemiology, pathology, and pathogenesis. In: Schumacher, H. R.; Klippel, J. H.; Koopman, W. J., ed. Primer on the rheumatic diseases. 10th ed. Arthritis Foundation, Atlanta, GA; 1993:86-89.