Tolerance and side-effects of paroxetine in elderly depressed patients

Archives of Gerontology and Geriatrics

Volumn 24, Issue 1, 1997, Pages 35-45

  Ghose, Karabi ^a,b  

^a Cardiff Royal Infirmary   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Choice reaction time; Critical flicker fusion; Depression; Elderly; Paroxetine; Salivary volume; Side effects

Indexed keywords

PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL FLICKER FUSION; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MALE; MENTAL DEFICIENCY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RESPONSE TIME; SLEEP DISORDER; SOMATIZATION;

EID: 0031017046     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(96)00725-X     Document Type: Article

References (20)

1. Brett, M.A., Dierdorf, H-D., Zussman, B.D. and Coats, P.E. (1987): Determination of paroxetine in human plasma, using high-performance liquid chromatography with fluorescence detection. J. Chromatogr., 419, 438-444.
2. Buus Lassen, J. (1978): Influence of the new 5-HT uptake inhibitor paroxetine on hypermobility in rats produced by p-chloramphetamine (PCA) and 4, α-dimethyl-m-tyramine (H77/77). Psychopharmacology, 57, 151-153.
3. Coppen, A. and Ghose, K. (1977): Do tricyclic antidepressants Work? Lancet, 1, 913-914.
4. Coppen, A., Ghose, K., Montgomery. S., Rao, V.A.R., Bailey, J., Christensen, J., Milkleson, P. L., Van Prag, H.M., Vande Pael, F., Minsker, E.S., Kozulga, V.C., Kungkunz, G., Matusse, K.N. and Jorgensen, A. (1978): Amitriptyline plasma concentration and clinical effect. (A multinational WHO Collaborative Study). Lancet, 1, 63-66.
5. Dechant, K.L. and Clissold, S.P. (1991): Paroxetine; A review of its pharmacodynamic and pharmacoki-netic properties, and therapeutic potential in depressive illness. Drugs, 41, 225-253.
6. Ghose, K. (1977): Lithium salts: therapeutic and unwanted effects. Br. J. Hosp. Med., 18, 579-583.
7. Ghose, K. (1987): Oxpentifylline in dementia: a controlled study. Arch. Gerontol. Geriatr., 6, 19-26.
8. Ghose, K. (1989a): The pharmacokinetics of paroxetine in elderly depressed patients. Acta Psychiatr. Scand., 80 (Suppl.), 87-88.
9. Ghose, K. (1989b): Side effects and interactions of tricyclic and related antidepressant drugs. In: Antidepressants for the Elderly, pp. 181-198. Editor: K. Ghose, Chapman and Hall, London.
10. Ghose, K. (1994): Prescribing CNS drugs for elderly patients. Drugs Aging, 4, 275-284.
11. Ghose, K. and Sedman, E. (1987): A double blind comparison of the pharmacodynamic effect of single doses of lofepramine, amitriptyline and placebo in elderly subjects. Eur. J. Clin. Pharmacol., 33, 505-509.
12. Ghose, K., Coppen, A. and Turner, P. (1976): Autonomie actions and interactions of mianserin hydrochloride (Org GB94) in patients with depressive illness. Psychopharmacology, 49, 201-204.
13. Hassan, S.M., Wainscoft, G. and Turner, P. (1985): A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test. Br. J. Clin. Pharmacol., 19. 705-706.
14. Hebenstreit, G.F., Fellerer, K., Zochling, R., Zentz, A. and Dunber, G.C. (1989): A pharmacokinetic dose titration study in adult and elderly depressed patients. Acta Psychiatr. Scand., 80 (Suppl. 350): 81-84.
15. Hindmarch, I. and Harrison, C. (1988): The effects of paroxetine and other antidepressants in combination with alcohol in psychomotor activity related to car driving. Hum. Psychopharmacol., 3: 13-20
16. Kaye, C.M., Haddock, R.E., Langley, P.F., Mellows, G., Tasker, T.C.G., Zussman, B.D. and Greb, W.H. (1989): A review of the metabolism and pharmacokinetics of paroxetine in man. Acta Psychiatr. Scand., 80 (Suppl. 350): 60-75.
17. Laursen, L.A., Mikkelsen, P.L., Rasmussen, S. and Honore, P.(1985): Paroxetine in the treatment of depression - a randomized comparison with amitriptyline. Acta Psychiatr. Scand., 71: 249-255
18. Rawlins, M. (1981): Adverse reaction to drugs. Br. Med. J., 282, 974-976
19. Schone, W. and Ludwig, M. (1994): Paroxetine in the treatment of depression in geriatric patients - a double blind comparative study with fluoxetine. Fortschr. Neurol. Psychiatr., 62 (Suppl. 1). 16-18
20. Thomas, D.R., Nelson, D.R. and Johnson, A.M. (1987): Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology, 93, 193-200.