Preclinical antitumor activity of water-soluble paclitaxel derivatives

Cancer Chemotherapy and Pharmacology

Volumn 39, Issue 6, 1997, Pages 486-492

  Rose, William C ^a   Clark, John L ^a   Lee, Francis Y F ^a   Casazza, Anna Maria ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anticancer; Taxanes; Taxol

Indexed keywords

BMS 185660; PACLITAXEL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LUNG CARCINOMA; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR MODEL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; PACLITAXEL; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 0031016893     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050603     Document Type: Article

References (19)

1. Adams JD, Flora KP, Goldspiel BR, Wilson JW, Arbuck SG, Finley R (1993) Taxol: a history of pharmaceutical development and current pharmaceutical concerns. Monogr Natl Canc Inst 15: 141
2. Burris H, Irvin R, Kuhn J, Kalter S, Smith L, Shaffter D, Fields S, Weiss G, Eckardt J, Rodriguez G, Rinaldi D, Wall J, Cook G, Smith S, Vreeland F, Bayssas M, LeBail N, Von Hoff D (1993) Phase I clinical trial of taxotere administered as either a 2-hour or 6-hour intravenous infusion. J Clin Oncol 11: 950
3. Chabner BA (1991) Taxol. Cancer: Principles and Practice of Oncology Updates. 5: 1
4. Deutsch HM, Glinski JA, Hernandez M, Haugwitz RD, Narayanan VL, Suffness M, Zalkow LH (1989) Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity. J Med Chem 32: 788
5. Einzig AI, Wienik PH, Schwartz EL (1992) Taxol: a new agent active in melanoma and ovarian cancer. In: Muggia FM (ed) New drugs, concepts and results in cancer chemotherapy. Kluwer Academic Publishers, Boston, p 89
6. Gehan EA (1985) A generalized Wilcoxon test for comparing arbitrarily singlycensored samples. Biometrika 52: 203
7. Golik J, Wong HSL, Chen SH, Doyle TW, Wright JJK, Knipe J, Rose WC, Casazza AM, Vyas DM (1996) Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs. Bioorg Med Chem Lett 6: 1837
8. Guéritte-Voegelein F, Guènard D, Lavelle F, Le Goff M-T, Mangatal L, Potier p (1991) Relationships between the structure of taxol analogues and their antimitotic activity J Med Chem 34: 992
9. Magri NF, Kingston DGI (1988) Modified taxols: 4. Synthesis and biological activity of taxols modified in the side chain. J Nat Prod 51: 298
10. Peereboom DM, Donehower RC, Eisenhauer EA, McGuire WP, Onetto N, Hubbard JL, Piccart M, Giani L, Rowinsky EK (1993) Successful re-treatment with taxol after major hypersensitivity reactions. J Clin Oncol 11: 885
11. Rose WC (1981) Evaluation of Madison 109 lung carcinoma as a model for screening antitumor drugs. Cancer Treat Rep 65: 299
12. Rose WC (1995) Preclinical antitumor activity of taxanes. In: Suffness M (ed) Taxol: science and applications. CRC Press, Boca Raton, p 209
13. Rose WC, Basler GA (1990) In vivo model development of cisplatin-resistant and sensitive A2780 human ovarain carcinomas. In Vivo 4: 391
14. Rowinsky EK, Cazenave LA, Donehower RC (1990) Taxol: a novel investigational antimicrotubule agent. J Natl Cancer Inst 82: 1247
15. Swindell CS, Krauss NE, Horwitz SB, Ringel I (1991) Bio logically active taxol analogues with deleted A-ring side chain substituents and variable C-2′ configurations. J Med Chem 34: 1176
16. Ueda Y, Mikkilineni AB Knipe JO, Rose WC, Casazza AM, Vyas DM (1993) Novel water soluble phosphate prodrugs of taxol possessing in vivo antitumor activity. Bioorg Med Chem Lett 3: 1761
17. Vyas DM, Wong H, Crosswell AR, Casazza AM, Knipe JO, Mamber SW, Doyle TW (1993) Synthesis and antitumor evaluation of water soluble taxol phosphates. Bioorg Med Chem Lett 3: 1357
18. Weiss RB, Donehower RC, Wiernik DH, Ohnuma T, Gralla RJ, Trump DL, Baker JR Jr, Van Echo DA, Von Hoff DD, Leyland-Jones B (1990) Hypersensitivity reactions from taxol. J Clin Oncol 8: 1263
19. Zhao Z, Kingston DGI, Crosswell AR (1991) Modified taxols 6. Preparation of water-soluble prodrugs of taxol. J Nat Prod 54: 1607