Stimulation of tetrapyrrole synthesis in mammalian epithelial cells in culture by exposure to aminolaevulinic acid

British Journal of Cancer

Volumn 75, Issue 3, 1997, Pages 381-387

  Washbrook, R ^a   Fukuda, H ^b   Battle, A ^b   Riley, P ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Aminolaevulinic acid; Haem; Porphyrin; Tetrapyrrole

Indexed keywords

AMINOLEVULINIC ACID; CYCLOHEXIMIDE; DACTINOMYCIN; HEME ARGINATE; PORPHYRIN; PYRROLE DERIVATIVE;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DENSITY; CELL METABOLISM; CONTROLLED STUDY; EPITHELIUM CELL; NONHUMAN; PORPHYRIN METABOLISM; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SERUM;

EID: 0031016233     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.62     Document Type: Article

References (28)

1. Batlle A and Riley PA (1991) Abnormality of heme synthesis as the initiating lesion in carcinogenesis. Cancer J 4: 326-331
2. Bedwell J, MacRobert AJ, Phillips D and Bown SG (1992) Fluorescence distribution and photodynamic effect of ALA-induced PPIX in the DMH rat colonic tumour model. Br J Cancer 65: 818-824
3. Divaris DXG, Kennedy JC and Pottier RH (1990) Phototoxic damage to sebaceous glands and hair follicle of mice after system administration of Δ-aminolevulinic acid, correlates with localized protoporphyrin IX fluorescence. Am J Path 136: 891-897
4. Fijan S, Honigsmann H and Ortel B (1995) Photodynamic therapy of epithelial skin tumours using Δ-aminolevulinic acid and desferrioxamme. Br J Dermatol 133: 282-288
5. Fukuda H, Paredes S and Batlle AMC (1989) Tumour-localising properties of porphyrins. In vitro studies using the porphyrin precursor Δ-amino-levulinic acid, in free and liposome encapsulated forms. Drug Des Deliv 5: 133-139
6. Fukuda H, Paredes S and Batlle AMC (1992a) Tumour-localising properties of porphyrins. In vivo studies using free and liposome encapsulated forms of Δ-aminolevulinic acid. Comp Biochem Physiol 102B: 433-436
7. Fukuda H, Paredes S, Casas A, Chueke F and Batlle AMC (1992b) Potential of liposome-entrapped Δ-aminolevulinic acid in cancer therapy. Effect of prior injection of empty liposomes and different routes of administration. Cancer J 5: 295-299
8. Fukuda H, Batlle AMC and Riley PA (1993) Kinetics of porphyrin accumulation in cultured epithelial cells exposed to ALA. Int J Biochem 25: 1407-1410
9. Gardener LC, Smith SJ and Cox TM (1991) Biosynthesis of Δ-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man. J Biol Chem 266: 22010-22018
10. Goldberg A and Rimington C (1962) Diseases of Porphyrin Metabolism. pp. 156-70. C Thomas:Springfield, Illinois, USA.
11. Granick S (1966) The induction of the synthesis of Δ-aminolevulinic acid synthase in chemical porphyria: a response to certain drugs, sex hormones and foreign chemicals. J Biol Chem 241: 1359-1375
12. Granick S and Sassa S (1971) Delta-aminolevulinic acid synthase and the control of haem and chlorophyll synthesis. In Metabolic Regulation. Vogel HJ (ed), pp. 77-141. Academic Press: NY, USA
13. Granick S, Sinclair D, Sassa S and Grieninger G (1975) Effects by haem, insulin and serum albumin on haem and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J Biol Chem 250: 9215-9225
14. Hamilton JW, Bement WJ, Sinclair PR, Sinclair JF, Alcedo JA and Wetterhahn KF (1991) Heme regulates hepatic Δ-aminolevulate synthase mRNA expression by decreasing mRNA half-life and not by altering it rate of transcription. Arch Biochem Biophys 289: 387-392
15. Iinuma S, Farshi SS, Ortel B and Hasan T (1994) A mechanistic study of cellular photodestruction with Δ-aminolevulinic acid-induced porphyrin. Br J Cancer 70: 21-28
16. Kreigmair RM, Baumgartner R, Knuchel R, Stepp H, Hofstadter F and Hofstetter A (1996) Detection of early bladder cancer by Δ-aminolevulinic acid induced porphyrin fluorescence. J Urol 155: 105-109
17. Loh CS, Vernon D, MacRobert AJ, Bedwell J, Bown SG and Brown SB (1993) Endogenous porphyrin distribution induced by Δ-aminolevulinic acid in the tissue layers of the gastrointestinal tract. J Photochem Photobiol B Biol 20: 47-54
18. Malik Z and Lugaci H (1987) Destruction of erythro-leukemic cells by photoactivation of endogenous porphyrins. Br J Cancer 156: 589-595
19. May BK, Bhasker CR, Bawden MJ and Cox TC (1990) Molecular regulation of Δ-aminolevulinate synthase. Diseases related to heme biosynthesis. Mol Biol Med 7: 405-421
20. Moretti MB, Garcia SRC, Stella C, Ramos EH and Batlle AMC (1993) Δ-aminolevulinic acid transport in Saccharomyces cerevisiae. Int J Biochem 25: 1917-1924
21. Moretti MB, Garcia SRC, Chianelli MS, Ramos EH, Mattoon JR and Batlle AMC (1995) Evidence that γ-aminobutyric acid and Δ-aminolevulinic acid share a common transport system into Saccharomyces cerevisiae. Int J Biochem Cell Biol 27: 169-173
22. Muller-Eberhard U and Nikkilä H (1989) Transport of tetrapyrroles by proteins. Semin Hematol 26: 86-104
23. Rimington C (1989) Haem biosynthesis and porphyrias: 50 years in retrospect. J Clin Chem Clin Biochem 27: 473-486
24. Roberts DJ and Cairnduff F (1995) Photodynamic therapy of primary skin cancer: a review. Br J Plast Surg 48: 360-370
25. Sassa S and Kappas A (1977) Induction of Δ-aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on the induction process. J Biol Chem 252: 2428-2436
26. Schwartz S, Dahl J, Ellefson M and Ahlquist D (1983) The 'Hemoquant' test: A specific and quantitative determination of heme (hemoglobin) in feces and other materials. Clin Chem 29: 2061-2067
27. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85
28. Steinbach P, Weingandt H, Baumgartner R, Kriegmair M, Hofstadter F and Knuchel R (1995) Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to Δ-aminolevulinic acid. Photochem Photobiol 6: 887-895