VB20B7, a novel 5-HT-ergic agent with gastrokinetic activity. II. Evaluation of the gastroprokinetic activity in rats and dogs

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 1, 1997, Pages 66-73

  Garcia Garayoa E ^a   Monge, A ^a   Roca, J ^b   Del Rio J ^a   Lasheras, B ^a,c  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Meteorological Service of Catalonia   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRIMONIDINE; PROKINETIC AGENT; SEROTONIN AGONIST; UNCLASSIFIED DRUG; VB 20 B7;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GASTROINTESTINAL MOTILITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SPECIES DIFFERENCE; STOMACH EMPTYING; STOMACH PARESIS;

EID: 0031016057     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06754.x     Document Type: Article

References (47)

1. Bermúdez, J., Dunbar, A., Sanger, G. J., Tamer, D. H. (1990) Stimulation of canine gastric motility by BRL 24924, a new gastric prokinetic agent. J. Gastrointest. Motil. 2: 281-286
2. Bertrand, J., Metmann, E. H, Danquechin Dorval E., Rouleau, P., D'Hueppe, A., Itti, R., Philippe, L. (1980) Etude du temps d'evacuation gastrique de repas normaux au moyen de granules radioopaques. Applications cliniques et validation. Gastroenterol. Clin. Biol. 4: 770-776
3. Buchheit, K. H., Costall, B., Engel, G., Gunning, S. J., Naylor, R. J., Richardson, B. P. (1985) 5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in vivo. J. Pharm. Pharmacol. 37: 664-667
4. 3 receptors increase gastric emptying of solids and liquids in the rat. Gastroenterology 96: A63
5. 2-agonist for the characterisation of α-adrenoceptor subtypes. Eur. J. Pharmacol. 72: 413-415
6. Camilleri, M., Brown, M. L., Zinsmeister, A. R. Malagelada, J-R. (1985) Cisapride corrects the impaired small bowel transit of chyme in chronic intestinal pseudoobstruction (abs). Gastroenterology 88: 1340
7. 3 receptor antagonist without gastroprokinetic activity. J. Pharmacol. Exp. Ther. 254: 350-355
8. 3 receptor antagonist on gastric emptying in the guinea-pig. Br. J. Pharmacol. 91: 263-264
9. 4 receptor. J. Pharmacol. Exp. Ther. 252: 1378-1386
10. 1,2,3,4 receptors. J. Pharmacol. Exp. Ther. 264: 79-88
11. Edwards, C. A., Holden, S., Brown, C., Read, N. W. (1987) Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 28: 13-16
12. 3 receptor antagonist, in vitro and in vivo. J. Pharmacol Exp. Ther. 266: 535-543
13. Feldman, M., Smith, H. J. (1987) Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo. Gastroenterology 92: 171-174
14. Feldman, M., Smith, H. J., Simon, T. R. (1984) Gastric emptying of solid radiopaque markers: studies in healthy subjects and diabetic patients. Gastroenterology 87: 895-902
15. 4 receptor. Med. Res. Rev. 13: 633-662
16. 3 receptor antagonist activity to gastric emptying and motor-stimulating actions of prokinetic drugs in dogs. J. Pharmacol. Exp. Ther. 258: 103-109
17. Gullikson, G. W., Viriña, M. A., Loeffler, R. F., Erwin, W. D. (1991b) Alpha-2-adrenergic model of gastroparesis: validation with renzapride, a stimulator of motility. Am. J. Physiol. 261: G426-G432
18. 4 receptor mechanism. J. Pharmacol. Exp. Ther. 264: 240-248
19. Harrington, R. A., Hamilton, C. W., Brogden, R. N., Linkewich, J. A., Romankiewicz, J. A., Heel, R. C. (1983) Metoclopramide: an updated review of its pharmacological properties and clinical use. Drugs 25: 451-494
20. Hinder, R. A., Kelly, K. A. (1977) Canine gastric emptying of solids and liquids. Am. J. Physiol. 233: E335-E340
21. Jacoby, H. I., Brodie, D. A. (1967) Gastrointestinal actions of metoclopramide. Gastroenterology 52: 676-684
22. Jian, R., Ducrot, F., Piedeloup, C., Mary, J. Y., Najean, Y., Bernier, J. J. (1985) Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride). Gut 26: 352-358
23. Kawagishi, T., Nishizawa, Y., Okuno, Y., Sekiya, K., Morii, H. (1993) Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy. Am. J. Gastroenterol. 88: 933-938
24. Kilbinger, H., Kruel, R., Pfeuffer-Friederich, I., Wessler, I. (1982) The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 319: 231-238
25. 3 receptors. Med. Res. Rev. 10: 441-475
26. King, F. D., Sanger, G. J. (1988) Gastrointestinal motility enhancing agents. Ann. Rep. Med. Chem. 23: 201-203
27. 3H]-acetylcholine release from guinea-pig stomach. J. Pharmacol. Exp. Ther. 234: 713-719
28. Lederer, P. D., Ellermann, A., Schmidt, H., Ernst, V., Lux, G. (1985) Effect of cisapride on sigmoid motility in healthy subjects and in diabetic enteropathy with constipation. Gastroenterology 88: 1468
29. McCallum, R. W., Prakash, C., Campoli-Richards, D. M., Goa, K. L. (1988) Cisapride: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 36: 652-681
30. Megens, A. A. H. P., Awouters, F. H. L., Niemegeers, C. J. E. (1991) General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine and cisapride. Arzneim. Forsch. 41: 631-634
31. Minami, H., McCallum, R. W. (1984) The physiology and pathophysiology of gastric emptying in humans. Gastroenterology 86: 1592-1610
32. Mizuta, H., Kawazoe, Y., Ogawa, K. (1990) Gastrointestinal absorption of chlorothiazide: evaluation of a method using salicylazosulfapyridine and acetaminophen as the marker compounds for determination of the gastrointestinal transit time in the dog. Chem. Pharm. Bull. 38: 2810-2813
33. 4 agonist properties. J. Med. Chem. 37: 1320-1325
34. Muller-Lissner, S. A., Fraas, C., Hard, A. (1986) Cisapride offset dopamine-induced slowing of fasting gastric emptying. Dig. Dis. Sci. 31: 807-810
35. 3 receptor antagonists on gastric emptying. Digestion 46: 89-96
36. Pinder, R. M., Brogden, R. N., Sawyer, P. R., Speight, T. M., Avery, G. S. (1976) Metoclopramide: a review of its pharmacological properties and clinical use. Drugs 12: 81-90
37. 4 receptors in guinea-pig ileum. Br. J. Pharmacol. 111: 419-424
38. 4 receptors. J. Pharm. Pharmacol. 49: 58-65
39. Rizzi, A., Sagrada, A., Schiavone, A., Schiantarelli, P., Cesana, R., Schiavi, G. B., Ladinsky, H., Donetti, A. (1994) Gastroprokinetic properties of the benzimidazolone derivative BIMU1, an agonist at 5-hydroxytryptamine4 and antagonist at 5-hydroxytryptamine3 receptors. Naunyn Schmiedebergs Arch. Pharmacol. 349: 338-345
40. 3 receptor antagonist properties. Neurogastroenterol. Motil. 6: 149
41. Sanger, G. J. (1987) Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL-24924: Potential clinical importance of BRL-24924. Br. J. Pharmacol. 91: 77-87
42. 3 receptor blockade. Eur. J. Pharmacol. 187: 323-329
43. Schuurkes, J. A. J. (1990) Effects of cisapride on gastric motility. Z. Gastroenterol. 28 (Suppl. 1): 27-30
44. Schuurkes, J. A. J., Van Nueten, J. M., Van Daele, P. G. H., Reytjens, A. J., Janssen, P. A. J. (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea-pig. J. Pharmacol. Exp. Ther. 234: 775-783
45. Wulschke, S., Ehrlein, H. J., Tsiamitas, C. (1986) The control mechanisms of gastric emptying are not overriden by motor stimulants. Am. J. Physiol. 251: G744-G751
46. Yoshida, N., Ito, T., Karasawa, T., Itoh, Z. (1991) AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J. Pharmacol. Exp. Ther. 257: 781-787
47. 2 receptor antagonist properties. Arch. Int. Pharmacodyn. Ther. 300: 51-67