Acute dietary tryptophan depletion: Effects on schizophrenic positive and negative symptoms

Neuropsychobiology

Volumn 35, Issue 1, 1997, Pages 5-10

  Sharma, Rajiv P ^a   Shapiro, Lisa E ^a   Kamath, Savitri K ^a   Soll, Elizabeth A ^a   Watanabe, Mark D ^a   Davis, John M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Diet; Schizophrenia; Serotonin; Tryptophan

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DIET; FEMALE; HUMAN; MALE; METHODOLOGY; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOIDISM; SCHIZOPHRENIA; SEROTONIN BRAIN LEVEL; SYMPTOM; TREATMENT FAILURE;

ADULT; BRAIN; CROSS-OVER STUDIES; DELUSIONS; DEPRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEROTONIN; TRYPTOPHAN;

EID: 0031015220     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119323     Document Type: Article

References (21)

1. 2 receptors and their involvement in schizophrenia and neuroleptic drug action. J Neural Transm 1983; 18(suppl):273-277.
2. Altar CA, Wasely AM, Neale RF, Stone GA: Typical and atypical antipsychotic occupancy of D; and Si receptors: An autoradiographic analysis in rat brain. Brain Res Bull 1986; 16: 517-525.
3. Meltzer UY, Stahl SM: The dopamine hypothesis of schizophrenia: A review. Schizophr Bull 1976;2:19-76.
4. Femstrom JD: Acute and chronic effects of protein and carbohydrate ingestion on brain tryptophan levels and serotonin synthesis. Nutr Rev 1986:May suppl:25-36.
5. Moja EA, Cipolla P, Castoldi D, Tofanetti O: Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats. LifeSci 1989;44:971-976.
6. Young SN, Ervin FR, Pihl RO, Finn P: Biochemical aspects of tryptophan depletion in primates. Psychopharmacology 1989:98:508-511.
7. Smith SE, Pihl RO, Young SN, Ervin FR: A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psycho-pharmacologv 1987;91:451-457.
8. Young SN, Smith SE, Pihl RO, Ervin FR: Tryptophan depletion causes a lowering of mood in normal males. Psychopharmacology 1985;87:173-177.
9. Young SN, Pihl RO, Ervin FR: The effect of altered tryptophan levels on mood and behavior in normal human males. Clin Neuropharmacol 1988:1 (suppl 1):S207-S215.
10. Benkellat C, Ellenbogen MA, Dean P, Palmour RM, Young SN: Mood lowering effect of tryptophan depletion. Arch Gen Psychiatry 1994: 51:687-697.
11. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR: Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 1990:47:411-418.
12. Delgado PL, Price LH, Miller ML, Salomon RM, Licinio J, Krystal JH. Hetlinger GR, Chamev DS: Rapid serotonin depletion as a provocative challenge test for patients with major depression: Relevance to antidepressant action and the neurobiology of depression. Psychopharmacol Bull 1991;27:321-330.
13. Salomon RM, Miller HL, Delgado PL, Charney DS: The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatrie disorders. Int Clin Psychopharmacol 1993;8(suppl 2):41-46.
14. Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ: Tryptophan depletion in normal volunteers produces selective impairments in leamingand memory. Neuropharmacology 1994:33:575-588.
15. Rosse RB, Schwartz BL, Zlotolow S, Banay-Schwartz M, Trinidad AC, Peace TD. Deutsch SI: Effect of a low-tryptophan diet as an adjuvant to conventional neuroleptic therapy in schizophrenia. Clin Neuropharmacol 1992:15: 129-141.
16. Meltzer HY, Matsubara S, Lee JC: Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-l. D-2 and serotonin-2 pki values. J Pharmacol Exp Ther 1989: 251:238-246.
17. Fernstrom JD: Aromatic amino acids and monoamine synthesis in the central nervous system: Influence of the diet. J Nutr Biochem 1990:1:508-517.
18. Delgado PL, Lawrence PH, Miller HL, Salomon RM, Aghajanian GK. Hcningcr GR. Chamey DS: Serotonin and the neurobiology of depression. Arch Gen Psychiatry 1994:51: 865-874.
19. Stahl SM, Uhr SB, Berger PA: Pilot study on the effects of fenfluramine on negative symptoms in twelve schizophrenic patients. Biol Psychiatry 1985:20:1098-1102.
20. Goldman MB, Janccek HM: Adjunctive fluoxetine improves global function in chronic schizphrenics. J Neuropsychiatry Clin Neurosci 1990:2:429-431.
21. Goff DC, Brotman AW, Waites M: Trial of fluoxetine added to neuroleptics for neuroleptic-resistant schizophrenic patients. Am J Psychiatry 1990:147:492-494.