MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: The Italian experience with 295 children

Journal of Clinical Oncology

Volumn 15, Issue 1, 1997, Pages 85-93

  Tonini, G P ^a   Boni, L ^a   Pession, A ^a,a   Rogers, D ^a   Iolascon, A ^a   Basso, G ^a   Cordero di Montezemolo, L ^a   Casale, F ^a   Perri, P ^a   Mazzocco, K ^a   Scaruffi, P ^a   Lo Cunsolo, C ^a   Marchese, N ^a   Milanaccio, C ^a   Conte, M ^a   Bruzzi, P ^a   De Bernardi, B ^a  

^a G GASLINI INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; LACTATE DEHYDROGENASE; NEURON SPECIFIC ENOLASE; VANILMANDELIC ACID;

ADOLESCENT; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CATECHOLAMINE RELEASE; CHILD; DISEASE ASSOCIATION; EXPERIENCE; FEMALE; GENE AMPLIFICATION; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; NEUROBLASTOMA; ONCOGENE; ONCOGENE C MYB; PRIORITY JOURNAL; PROGNOSIS;

EID: 0031014625     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.1.85     Document Type: Article

References (40)

1. Hayes FA, Smith El: Neuroblastoma, in Pizzo AP, Poplack GP (eds): Principles and Practice of Pediatric Oncology (ed 2). London, United Kingdom, Lippincott, 1993, pp 607-622
2. De Bernardi B, Conte M, Mancini A, et al: Localized resectable neuroblastoma: Results of the second study of the Italian Cooperative Group for Neuroblastoma. J Clin Oncol 13:884-893, 1995
3. Garaventa A, De Bernardi B, Pianca C, et al: Localized but unresectable neuroblastoma: Treatment and outcome of 145 cases. J Clin Oncol 11:1770-1779, 1993
4. De Bernardi B, Carli M, Casale F, et al: Standard-dose and high-dose peptichemio and cisplatin in children with poor-risk neuroblastoma: Two studies by the Italian Cooperative Group for Neuroblastoma. J Clin Oncol 10:1870-1878, 1992
5. De Bernardi B, Di Tullio MT, Cordero di Montezemolo L, et al: Neuroblastoma under one year of age. Clinical aspects and management. Contrib Oncol 41:118-128, 1990
6. Bertani-Dziedzic L, Dziedzic SW, Gitlow SE: Catecholamine metabolism in neuroblastoma, in Pochedly C (ed): Neuroblastoma: Tumor Biology and Therapy. Boca Raton, FL, CRC, 1990, pp 69-91
7. Shuster JJ, McWilliams NB, Castleberry R, et al: Serum lactate dehydrogenase in childhood neuroblastoma. Am J Clin Oncol 15:295-303, 1992
8. Hahn HWL, Levy HM, Evans AE: Serum ferritin as a guide to therapy in neuroblastoma. Cancer Res 40:1411-1413, 1980
9. Zeltzer PM, Marangos PJ, Evans AE, et al: Serum neuron specific enolase in children with neuroblastoma. Relationship to stage and disease course. Cancer 57:1230-1234, 1986
10. Brodeur GM, Seeger RC, Schwab M, et al: Amplification of N-myc in untreated human neuroblastoma correlates with advanced stage. Science 224:1121-1124, 1984
11. Seeger RC, Brodeur GM, Sather H, et al: Association of multiple copies of N-myc oncogene with rapid progression of neuroblastoma. N Engl J Med 313:1111-1116, 1985
12. Bartram CR, Berthold F: Amplification and expression of N-myc gene in neuroblastoma. Eur J Pediatr 146:162-165, 1987
13. Tsuda T, Obara M, Hirano H, et al: Analysis of N-myc amplification in relation to disease stage and histologic types in human neuroblastomas. Cancer 60:820-826, 1987
14. Taylor SR, Lochker J: A comparative analysis of nuclear DNA content and N-myc amplification in neuroblastoma. Cancer 65:1360-1366, 1990
15. Look AT, Hayes FA, Shuster J, et al: Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A Pediatric Oncology Group study. J Clin Oncol 9:581-591, 1991
16. Bourhis J, De Vathaire F, Eison GD, et al: Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma. Cancer Res 51:33-36, 1991
17. Hiyama E, Hiyama K, Yokoyama T, et al: Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients. J Pediatr Surg 26:838-843, 1991
18. Hedborg F, Lindgren PG, Johansonn I, et al: N-myc gene amplification in neuroblastoma: A clinical approach using ultrasound guided cutting needle biopsies collected at diagnosis. Med Pediatr Oncol 20:292-300, 1992
19. Muraji T, Okamoto E, Fujimoto J, et al: Combined determination of N-myc oncogene amplification and DNA ploidy in neuroblastoma. Cancer 72:2763-2768, 1993
20. Michon J, Delattre O, Zucker JM, et al: Prospective evaluation of N-myc amplification and deletion of the short arm of chromosome 1 in neuroblastoma tumours: A single institution study, in Evans AE, D'Angio G, Nakagawara A, et al (eds): Advances in Neuroblastoma Research, vol 4. New York, NY, Wiley-Liss, 1994, pp 11-17
21. Tonini GP, Verdona G, De Bernardi B, et al: N-myc oncogene amplification in a patient with IV-S neuroblastoma. Am J Pediatr Hematol Oncol 9:8-11, 1987
22. Sansone R, Strigini P, Badiali M, et al: Age-dependent prognostic significance of N-myc amplification in neuroblastoma. Cancer Genet Cytogenet 54:253-257, 1991
23. Brodeur GM, Seeger RC, Barrett A, et al: International criteria for diagnosis, staging and response to treatment in patients with neuroblastoma. J Clin Oncol 6:1874-1881, 1988
24. Southern EJ: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503-517, 1975
25. Tonini GP, Verdona G, Garaventa A, Cornaglia Ferraris P: Antiblastic treatment does not affect N-myc gene amplification in neuroblastoma. Anticancer Res 7:729-732, 1987
26. Freimberg AP, Vogelstein P: A technique for radiolabeling DNA restrinction endonuclerase fragments to high specific activity. Anal Biochem 1 32:6-123, 1984
27. Fleiss JI: Statistical Methods for Rates and Proportions (ed 2). New York, NY, Wiley, 1981
28. Peto R, McPherson K, Peto J, et al: Design and analysis of clinical trials requiring prolonged observation of each patient. Br J Cancer 35:1-39, 1977
29. Marubini E, Valsecchi MG: Analysing Survival Data from Clinical Trials and Observational Studies. Chichester, England, Wiley, 1995
30. Cox DR: Regression models and life-tables (with discussion). J R Stat Soc 34:187-220, 1972
31. Sprandling AC, Mahowald AP: Amplification of genes for chorion proteins during oncogenesis in Drosophila melanogaster. Proc Natl Acad Sci USA 77:1096-2002, 1980
32. Stark GR, Debatin M, Giulotto E, Wahl GM: Recent progress in understanding mechanisms of mammalian DNA amplification. Cell 57:901-908, 1989
33. Alitalo K, Schwab M: Oncogene amplification in tumor cells. Adv Cancer Res 47:235-279, 1986
34. Schwab M, Alitalo K, Klempnauer KH, et al: Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 305:245-248, 1983
35. Schwab M, Varmus HE, Bishop JM, et al: Chromosome localization in normal human cells and neuroblastomas of a gene related to N-myc. Nature 308:288-291, 1984
36. Cohn SL, Look AT, Joshi VV, et al: Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: A Pediatric Oncology Group study. Cancer Res 55:721-726, 1995
37. Wilson PCG, Coppes MJ, Solh H, et al: Neuroblastoma stage IV-S: A heterogeneous disease. Med Pediatr Oncol 19:467-472, 1991
38. Bourhis J, Dominici C, McDowell H, et al: N-myc genomic content and DNA ploidy in stage IVS neuroblastoma. J Clin Oncol 8:1371-1375, 1991
39. Nakagawara A, Sasazuki T, Akiyama H, et al: N-myc oncogene and stage IV-S neuroblastoma. Cancer 65:1960-1967, 1990
40. Thiele CJ, Reynolds CP, Israel MA: Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature 313:404-406, 1985