Metabolic changes in elderly cancer patients after glucose ingestion: The role of tumor necrosis factor-α

Cancer

Volumn 79, Issue 1, 1997, Pages 177-184

  Gambardella, Antonio ^a   Tortoriello, Rosa ^a   Tagliamonte, Maria Rosaria ^a   Paolisso, Giuseppe ^a,b   Varricchio, Michele ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Servizio di Astanteria Medica   (Italy)

Author keywords

cancer; glucose induced thermogenesis; substrate oxidation; tumor necrosis factor

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LACTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BASAL METABOLIC RATE; CALORIMETRY; CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LIPID OXIDATION; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; THERMOGENESIS;

AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; BODY TEMPERATURE REGULATION; ENERGY METABOLISM; FATS; FEMALE; GLUCOSE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OXIDATION-REDUCTION; PROTEINS;

EID: 0031014505     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19970101)79:1<177::AID-CNCR25>3.0.CO;2-0     Document Type: Article

References (23)

1. Tataranni PA, Larson DE, Snitker S, Ravussin E. Thermic effect of food in humans: methods and results from use of a respiratory chamber. Am J Clin Nutr 1995;61:1013-9.
2. Hytlander A, Drott C, Korner U, Sandstrom R, Lundholm K. Elevated energy expenditure in cancer patients with solid tumors. Eur J Cancer 1991;27:9-15.
3. Hytlander A, Korner U, Lundholm K. Evaluation of the mechanisms behind elevated energy expenditure in cancer patients with solid tumors. Eur J Clin Invest 1993;23:46-52.
4. Bianchi A, Bruce J, Cooper AL, Childs C, Kohli M, Morris ID. Increased brown adipose tissue activity in children with malignant diseases. Horm Metab Res 1989;21:640-1.
5. Drott C, Svaninger G, Lundholm K. Increased unrinary excretion of cortisol and catecholamines in malnourished cancer patients. Ann Surg 1988;208:645-50.
6. Balkwill F, Osborne R, Burke F, Naylor S, Talbot D, Durbin H. Evidence for tumor necrosis factor/cachectin production in cancer. Lancet 1987;2:1229-32.
7. Gambardella A, Paolisso G, D'Amore A, Granato M, Verza M, Varricchio M. Different contribution of substrates oxidation to insulin resistance in malnourished elderly patients with cancer. Cancer 1993;72:3106-13.
8. Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factors impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992;130:43-52.
9. Spiegelman B, Hotamisligil GS. Through thick and thin: wasting, obesity and TNF-α. Cell 1993;73:625-7.
10. Hotamisligil GS, Spiegelman B. Tumor necrosis factor-α: a key component of obesity-diabetes link Diabetes 1994; 43:1271-8.
11. Ferrannini E. The theoretical basis of indirect calorimetry: a review. Metabolism 1988;37:287-301.
12. Dole VP, Meinertz H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem 1960; 235:2595-9.
13. Bistrian BR, Blackburn GL, Flatt JP. Nitrogen metabolism and insulin requirements in obese diabetic adults on a protein-sparing modified fast. Diabetes 1976;25:494-504.
14. Feingold KR, Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes 1992;41(Suppl 2):97-101.
15. Grunfeld C, Feingold KR. The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy 1991;3:143-58.
16. Douglas RG, Gluckman PD, Breir BH, McCall JL, Parry B, Shaw JH. Effects of recombinant IGF-I on protein and glucose metabolism in rTNF-infused lambs. Am J Physiol 1991;261:E606-12.
17. Norman RA, Bogardus C, Ravussin E. Linkage between obesity and a marker near the tumor necrosis factor-α locus in Pima Indians. J Clin Invest 1995;96:158-62.
18. Hoffman C, Lorenz K, Braithwaite SS, Colca JR, Palazuk J, Gokhans S. Altered gene expression for tumor necrosis-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994;134:264-70.
19. Bennegard K, Eden E, Ekman L, Schersten T, Lundholm K. Metabolic response of whole body and peripheral tissues to enterai nutrition in weight-losing cancer and noncancer patients. Gastroenterology 1983;85:92-9.
20. Sakurai Y, Zhang XJ, Wolfe RR. Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs. J Clin Invest 1993;91:2437-45.
21. Fain JW, Garcia-Sainz JA. Adrenergic regulation of adipocyte metabolism. J Lipid Res 1983;24:945-66.
22. Randle PJ, Hales CN, Garland PB, Newaholme EA. The glucose fatty-acid cycle. Its role in insulin insensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; I:785-9.
23. Kelley DE, Mokan M, Simoneau JA, Mandarino L. Interaction between glucose and free fatty metabolism in human skeletal muscle. J Clin Invest 1993;92:91-8.