Structure and function in IgA

Chemical Immunology

Volumn 65, Issue , 1997, Pages 73-87

  Hexham, J Mark ^a   Carayannopoulos, Leonidas ^a   Capra, J Donald ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN FC FRAGMENT; SECRETORY IMMUNOGLOBULIN;

ARTICLE; HUMAN; IMMUNOGLOBULIN STRUCTURE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; IMMUNOGLOBULIN A;

EID: 0031014493     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (113)

1. Burton DR, Woof JM: Human antibody effector functions. Adv Immunol 1992;51:1-84.
2. Childers NK, Bruce MG, McGhee JR: Molecular mechanisms of immunoglobulin A defense. Annu Rev Microbiol 1989;43:503-536.
3. Koshland ME: The coming of age of the immunoglobulin J chain. Annu Rev Immunol 1985;3: 425-453.
4. Mostov KE, Blobel G: A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins. J Biol Chem 1982;257:11816-11821.
5. Mostov KE: Transepithelial transport of immunoglobulins. Ann Rev Immunol 1994;12:63-84.
6. Underdown BJ, Schiff JM: Immunoglobulin A: Strategic defense initiative at the mucosal surface. Ann Rev Immunol 1986;4:389-417.
7. Kilian M, Mestecky J, Russell MW: Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases. Microbiol Rev 1988;52:296-303.
8. Mestecky J, McGhee JR: Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 1987;40:153-245.
9. Jonard PP, Rambaud JC, Dive C, Vaerman JP, Galian A, Delacroix D: Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A. J Clin Invest 1984;74:525-535.
10. Shen L, Lasser R, Fanger MW: My 43, a monoclonal antibody that reacts with human myeloid cells inhibits monocyte IgA binding and triggers function. J Immunol 1989;143:4117-422.
11. Monteiro RC, Kubagawa H, Cooper MD: Cellular distribution, regulation and biochemical nature of an Fca receptor in humans. J Exp Med 1990;148:597-613.
12. Maliezewski CR, March CJ, Schoenborn MA, Gimpel S, Shen L: Expression cloning of a human Fc receptor for IgA. J Exp Med 1990;172:1665-1672.
13. Monteiro RC, Hostoffer RW, Cooper MD, Bonner JR, Gartland GL, Kubagawa H: Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals. J Clin Invest 1993;92:1681-1685.
14. Kurita T, Kiyono H, Komiyama K, Grossi CE, Mestecky J, McGhee JR: Isotype-specific immunoregulation; characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor. J Immunol 1986;136:3953-3960.
15. Weisbart RH, Kacena A, Schuh A, Golde DW: GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism. Nature 1988;332:647-648.
16. Lamkhioued B, Gounni AS, Gruart V, Pierce A, Capron A, Capron M: Human eosinophils express a receptor for secretory component. Role in secretory IgA-dependent activation. Eur J Immunol 1995;25:117-125.
17. Lucisano-Valim YM, Lachmann PJ: The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: A systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin Exp Immunol 1991;84:1-8.
18. Carayannopoulos LN, Max EE, Capra JD: Recombinant human IgA expressed in insect cells. Proc Natl Acad Sci USA 1994;91:8348-8352.
19. Mazanec MB, Kaetzel CS, Lamm ME, Fletcher D, Nedrud JG: Intracellular neutralization of virus by IgA antibodies. Proc Natl Acad Sci USA 1992;89:7252-7256.
20. Grzych JM, Grezel D, Xu C, Neyrinck JL, Capron M, Ouma JH, Butterworth AE, Capron A: IgA antibodies to a protective antigen in human Schistosoma mansoni. J Immunol 1993;150:527-535.
21. Clarkson AR, Woodroffe AJ, Bannister KM, Lomax-Smith JD, Aarons I: The syndrome of IgA nephropathy. Clin Ncphrol 1984;21:7-14.
22. Kitani S, Ito K, Miyamoto T: IgG, IgA, and IgM antibodies to mite in sera and sputa from asthmatic patients. Ann Allergy 1985;55:612 620.
23. Popper H, Pongratz M, Lanzer G: IgA2-alveolitis and eosinophilic pneumonia - a possibly virus-triggered allergy Allergol Immunopathol (Madr) 1982;10:177-184.
24. Mostov KE, Freidlander M, Blobel G: The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 1984;308:3743.
25. Flanagan JG, Rabbitts TH: Arrangement of human immunoglobulin heavy chain gene segments implies evolutionary duplication of a segment containing γ, ε and α genes. Nature 1982;300:709-711.
26. Torano A, Putnam FW: Complete amino acid sequence of the α2 heavy chain of a human IgA2 immunoglobulin of the A2 in (2) allotype. Proc Natl Acad Sci USA 1978;75:966-969.
27. Putnam FW, Liu YSV, Low TLK: Primary structure of a human IgA1 immunoglobulin. J Biol Chem 1979;254:2865-2874.
28. Tsuzukida Y, Wang CC, Putnam FW: Structure of the A2m(1) allotype of human IgA-A recombinant molecule. Proc Natl Acad Sci USA 1979;76:1104-1108.
29. Garcia-Pardo A, Lamm ME, Plaut AG, Frangione B: J chain is covalently bound to both monomer subunits in human secretory IgA. J Biol Chem 1981;256:11734-11738.
30. Davis AC, Roux KH, Schulman MJ: On the structure of polymeric IgM. Eur J Immunol 1988;18: 1001-1008.
31. Torano A, Tsuzukida Y, Liu YSV, Putnam FW: Location and significance of oligosaccharides in human IgA1 and IgA2 immunoglobulins. Proc Natl Acad Sci USA 1977;74:2301-2305.
32. Chintalaruvu KR, Raines M, Morrison SL: Divergence of human α-chain constant region gene sequences: A novel recombinant α2 gene. J Immunol 1994;152:5299-5304.
33. Grey HM, Abel CA, Yount WJ, Kunkel HG: A subclass of human αA globulins (αA2) which lacks the disulfide bonds linking heavy chains and light chains. J Exp Med 1968;128:1223-1236.
34. Carayannopoulos LN, Capra JD: Immunoglobulins: Structure and Function: in Paul WE (ed): Fundamental Immunology. New York, Raven Press, 1993, pp 283-314.
35. Tomana M, Neidermeyeier W, Mestecky J, Skvaril F: The differences in carbohydrate composition between the subclasses of IgA immunoglobulins. Immunochemistry 1976;13:324-328.
36. Baenziger J, Kornfield S: Structure of the carbohydrate units of human IgA1 immunoglobulin. I. Composition, glycopeptide isolation and structure of the asparagine-linked oligosaccharide units. J Biol Chem 1974;249:7260-7269.
37. Baenziger J, Kornfield S: Structure of the carbohydrate units of human IgA1 immunoglobulin. II. Structure of the O-linked oligosaccharide units. J Biol Chem 1974;249:7270-7281.
38. Roque-Barriera MC, Campos-Neto A: Jacalin: An IgA-binding lectin. J Immunol 1985;134:1740-1743.
39. Zikan J, Mestecky J, Kulhavy R, Bennet JC: The stochiometry of J chain in human dimeric IgA. Mol Immunol 1986;23:541-544.
40. Bastian A, Kratzin H, Eckart K, Hilschmann N: Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A. Biol Chem Hoppe-Seyler 1992;373:1255-1263.
41. Despont JPJ, Abel CA, Grey HM, Penn GM: Structural studies on a human IgA1 myeloma protein with a carboxy-terminal deletion. J Immunol 1974;112:1517-1525.
42. Cattaneo A, Neuberger MS: Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. EMBO J 1987;6:2753-2758.
43. Davis AC, Roux KH, Pursey J, Shulman MJ: Intermolecular disulfide bonding in IgM: Effects of replacing cysteine residues in the μ 4eavy chain. EMBO J 1989;8:2519-2526.
44. Davis AC, Schulman MJ: IgM molecular requirements for its assembly and function. Immunol Today 1989;10:118-126.
45. Hendrickson BA, Conner DA, Ladd DJ, Kendall D, Casanova JE, Corthesy B, Max EE, Neutra MR, Seidman CE, Seidman JG: Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med 1995;182:1905-1911.
46. Brandtzaeg P: Complex formation between secretory component and human immunoglobulins related to their content of J chain. Scand J Immunol 1976;5:411-419.
47. Brandtzaeg P, Prydz H: Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 1984;311:71-73.
48. Tomasi TB, Czerwinski DS: Naturally occurring polymers of IgA lacking J chain. Scand J Immunol 1976;5:647-653.
49. Ma JKC, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleward C, Mostov KE, Lehner T: Generation and assembly of secretory antibodies in plants. Science 1995;268:716-719.
50. Smith RIF, Coloma MJ, Morrison SL: Addition of a μ-tailpiece to IgG results in polymeric antibodies with enhanced effector fuctions including complement-mediated cytolysis by IgG4. J Immunol 1994; 154:2226-2236.
51. Sorensen V, Rasmussen IB, Norderhaug L, Natvig I, Michaelsen TE, Sandlie I: Effect of the IgM and IgA secretory tailpieces on polymerization and secretion of IgM and IgG. J Immunol 1996; 156:2858-2865.
52. Schiff JM, Fisher MM, Underdown BJ: Secretory component as the mucosal transport receptor: Separation of physicochemically analogous human IgA fractions with different receptor-binding capacities. Mol Immunol 1986;23:45-56.
53. Underdown BJ, De Rose J, Plaut A: Disulfide bonding of secretory component to a single monomer subunit in human secretory IgA. J Immunol 1977;118:1816-1821.
54. Eiffert H, Quentin E, Decker J, Hillemeir S, Hufschmidt M, Klingmuller D, Weber MH, Hilschmann N: Die Primastruktur der menschlichen freien Sekretkomponente und die Anordnung der Disulfidbrücken. Hoppe-Seylers Z Physiol Chem 1984;365:1489-1495.
55. Krajci P, Kvale D, Tasken K, Brandzaeg P: Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor). Eur J Immunol 1992;22:2309-2315.
56. Banting G, Brake B, Braghetta P, Luzio JP, Stanley KK: Intracellular targetting signals of polymeric immunoglobulin receptors are highly conserved between species. FEBS Lett 1989;254:177-183.
57. Piskurich JF, Blanchard MH, Youngman KR, France JA, Kaetzel CS: Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J Immunol 1995;154:1735-1747.
58. Verbeet MP, Vermeer H, Warmerdam GCM, de Boer HA, Lee SH: Cloning and characterization of the bovine polymeric immunoglobulin receptor encoding cDNA. Gene 1995;164:329-333.
59. Deitcher DL, Mostov KE: Alternate splicing of rabbit polymeric immunoglobulin receptor. Mol Cell Biol 1986;6:2712-2715.
60. Frutiger S, Hughes J, Fonck C, Jaton JC: High and low molecular weight rabbit secretory components. J Biol Chem 1987;262:1712-1715.
61. Kulseth MA, Krajci P, Myklebost O, Rogne S: Cloning and characterization of two forms of the bovine polymeric immunoglobulin receptor cDNA. DNA Cell Biol 1995;3:251-256.
62. Kuhn L, Kocher HP, Hanly WC, Cook L, Jaton JC: Structural and genetic heterogeneity of the receptor mediating translocation of immunoglobulin A dimer antibodies across epithelia in the rabbit. J Biol Chem 1983;258:6653-6659.
63. Frutiger S, Hughes GJ, Hanly WC, Kingzette M, Jaton JC: The amino terminal domain of rabbit secretory component is responsible for noncovalent binding to immunoglobulin A dimers. J Biol Chem 1986;261:16673-16681.
64. Kuhn LC, Kraehenbuhl JP: Interaction of rabbit secretory component with rabbit IgA dimer. J Biol Chem 1979;254:11066-11071.
65. Bakos M, Kurowsky A, Goldblum RM: Characterization of a critical binding site for human polymeric Ig on secretory component. J Immunol 1991;147:3419-3426.
66. Bakos M, Kurowsky A, Woodward CS, Denney RM, Goldblum RM: Probing the topography of free and polymeric Ig-bound human secretory component with monoclonal antibodies. J Immunol 1991;146:162-168.
67. Coyne RS Siebrecht M, Pietsch MC, Casanove JE: Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. J Biol Chem 1994;269:31620-31625.
68. Lindh E, Bjork I: Binding of secretory component to dimers of immunoglobuhn A m vitro. Eur J Biochem 1974;45:261-268.
69. Cunningham-Rundles C, Lamm ME: Reactive half cystine peptides of the secretory component of human exocrine immunoglobulin A. J Biol Chem 1975;250:1987-1991.
70. Fallgreen-Gebauer E, Gebauer W, Bastian A, Kratzin HD, Eiffert H, Zimmermann B, Karas M, Hilschman N: The covalent linkage of secretory component to IgA. Biol Chem Hoppe-Seyler 1993; 374:1023-1028.
71. Chintalacharuvu KR, Tavill AS, Loui EN, Vaerman JP, Lamm ME, Kaetzel CS: Disulphide bond formation between dimeric IgA and the polymeric immunoglobulin receptor during hepatic transcytosis. Hepatology 1994;19:162-173.
72. Burnet RC, Hanly WC, Zhai SK, Knight KE: The IgA heavy chain gene family in rabbit: Cloning and sequence analysis of 13 Cα genes. EMBO J 1989;8:4041-4047.
73. Liew TN Russell SM, Appleyard G, Brand CM, Beale J: Cross-protection in mice infected with influenza virus is correlated with local IgA activity rather than serum antibody or cytoloxic T cell reactivity Eur J Immunol 1984;14:350.
74. Tarkowski A, Lue C, Moldoveneau Z, Kiyono H, McGhee JR, Mestecky J: Immunization of humans with polysaccharide vaccines induces systemic predominantly IgA2-subclass antibody responses. J Immunol 1990;144:3770-3778.
75. Hajishengallis G, Nikolova E, Russell MW: Inhibition of Streptococcus mutans adherence to saliva coated hydroxy-apatite by human secretory antibodies to cell surface protein antigen I/IE: Reversal by IgA protease cleavage. Infect Immunol 1992;60:5057-5064.
76. Grzych JM, Grezel D, Xu C, Neyrinck JL, Capron M, Ouma JH, Butterworth AE, Capron A: IgA antibodies to a protective antigen in human Schistosoma mansoni. J Immunol 1993;150:527-535.
77. Carayannopoulos L, Hexham JM, Capra JD: Localization of the binding site for the monocyte IgA-Fc receptor (CD89) to the domain boundary between Cα2 and Cα3 in human IgA1. J Exp Med 1996;183:1579-1586.
78. Woof JM, Partridge EJ, Jefferis R, Burton DR: Eocalisation of the monocyte binding region on human IgG. Mol Immunol 1986;23:319-330.
79. Nissim A, Eshhar Z: The human mast cell receptor binds to the third constant domain of immunoglobulin E. Mol Immunol 1992;29:1065-1072.
80. Deisenhofer J: Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9 and 2.8 ångstroms resolution. Biochemistry 1981;20:2361-2370.
81. Kim JK, Tsen MF, Ghetie V, Ward ES: Localization of the site of the murine IgG1 mo ecule that is involved in binding to the murine intestinal Fc receptor. Eur J Immunol 1994;24:2429-2434.
82. Kim JK, Tsen MF, Chetie V, Ward ES: Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site directed mutagenesis. Eur J Immunol 1994;24:542-548.
83. Schneiderman RD, Lint, TF, Knight KE: Activation of the alternative pathway of comp emen by twelve different mouse-rabbit chimeric transfectoma IgA isotypes. J Immunol 1990;145:233-237.
84. Rits M, Hiemstra PS, Bazin H, van Es EA, Vaerman JP, Daha MR: Activation of rat complement by soluble and insoluble rat IgA immune complexes. Eur J Immunol 1988;18:1873-1880.
85. Mazanec MB, Nedrud JG, Kaetzel CS, Lamm ME: A three-tiered view of the role of IgA in mucosal defense. Immunol Today 1993;14:430-435.
86. Kaetzel CS, Robinson JK, Chintalacharuvu KR, Vaerman JP, Lamm ME: The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: A local defense function for IgA. Proc Natl Acad Sci USA 1991;88:8796-8800.
87. Kaetzel CS Robinson JK, Lamm ME: Epithelial transcytosis of monomeric IgA and IgG cross linked through antigen to polymeric IgA. J Immunol 1994;152:72-78.
88. Vaerman JP, Heremans JF, van Kerckhoven G: The identification of IgA in several mammalian species. J Immunol 1969;103:1421-1423.
89. Bell RB, Stephens CJ, Turner KJ: Marsupial immunoglobuhns: An immunoglobulin resembling eutherian IgA in serum and secretions. J Immunol 1974;113:371-378.
90. Lebacq-Verheyden AM, Vaerman JP, Heremans JF: A possible homologue of mammalian IgA in chicken serum and secretions. Immunology 1972;22:165-175.
91. Mansikka A: Chicken IgA H chains: Implications concerning the evolution of H chain genes. J Immunol 1992;149:855-861.
92. Portis JL, Coe JE: IgM the secretory immunoglobulin of reptiles and amphibians. Nature 1975; 258:547-548.
93. Lobb CJ, Clem LW: Phytogeny of immunoglobulin structure and function XI: Secretory immunoglobulins in the cutaneous mucus of sheepshead, Achosargus probatocephalus. Dev Comp Immunol 1981;5:587-596.
94. Burnet RC, Hanly WC, Zhai SK, Knight KL: The IgA heavy chain gene family in rabbit: Cloning and sequence analysis of 13 Ca genes. EMBO J 1989;8:4041-4047.
95. Schneiderman RD, Hanly WC, Knight KL: Expression of 12 rabbit IgA Ca genes as chimeric rabbit-mouse IgA antibodies. Proc Natl Acad Sci USA 1989;86:7561-7565.
96. Spieker-Polet H, Yam P-C, Knight KL: Differential expression of 13 IgA heavy chain genes in rabbit lymphoid tissues. J Immunol 1993;150:5457-5465.
97. Plaut AG: The IgA1 proteases of pathogenic bacteria. Annu Rev Microbiol 1983;37:603-622.
98. Max EE, Korsmeyer SJ: Immunoglobulin J chain gene. Structure and expression in B lymphoid cells. J Exp Med 1985;161:832-849.
99. Matsuuchi L, Cann GM, Koshland ME: Immunoglobulin J chain gene from the mouse. Proc Natl Acad Sci USA 1986;83:456-460.
100. Kulseth MA, Rogne S: Cloning and characterization of the bovine immunoglobulin J chain cDNA and its promoter region. DNA Cell Biol 1994; 13:37-42.
101. Hughes GJ, Frutiger S, Paquet N, Jaton JC: The amino acid sequence of rabbit J chain in secretory immunoglobulin A. Biochem J 1990;271:641-647.
102. Mikoryak CA, Margolies MN, Steiner LA: J chain in Rana catesbeiana high molecular weight Ig. J Immunol 1988;140:4279-4285.
103. Takahashi T, Iwase T, Takenuchi N, Saito M, Kobayashi K, Moldoveanu Z, Mestecky J, Moro I: The joining (J) chain is present in invertebrates that do not express immunoglobulins. Proc Natl Acad Sci USA 1996;93:1886-1891.
104. Morton HC, Atkin JD, Owens RJ, Woof JM: Purification and characterisation of chimeric human IgAl and IgA2 expressed in COS and Chinese hamster ovary cells. J Immunol 1993;151:4743-4752.
105. Rindisbacher L, Cottet S, Witteek R, Kraehenbuhl J-P: Production of human secretory component with dimeric IgA binding capacity using viral expression systems. J Biol Chem 1995;270:14220-14228.
106. Ma JKC, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleward C, Mostov KE, Lehner T: Generation and assembly of secretory antibodies in plants. Science 1995;268:716-719.
107. Lo D, Pursel V, Linton PJ, Sandgren E, Behringer R, Rexroad C, Palmiter RD, Brinster RL: Expression of mouse IgA by transgenic mice pigs and sheep. Eur J Immunol 1991;21:1001-1006.
108. Mestecky J, McGhee JR: Prospects for human mucosal vaccines. Adv Exp Med Biol 1992;327:13-23.
109. Czerkinsky C, Quiding M, Eriksson K, Nordstrom I, Lakew M, Weneras CAK, Bjorck S, Svennerholm AM, Butcher E: Induction of specific immunity at mucosal surfaces: Prospects for vaccine development. Adv Exp Med Biol 1995;371B:1409-1416.
110. Chen SY, Bagley J, Marasco WA: Human Gene Therapy 1994;5:595-601.
111. Ferkol T, Kaetzel CS, Davis PB: Recombinant human respiratory sycytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. J Clin Inv 1993;92:2394-2400.
112. Burton DR: Monoclonal antibodies from combinatorial libraries. Accounts Chem Res 1993;26: 405-411.
113. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR: Making antibodies by phage display technology. Annu Rev Immunol 1994;12:433-455.