Identification of naturally processed human ovarian peptides recognized by tumor-associated CD8+ cytotoxic T lymphocytes

Cancer Research

Volumn 57, Issue 1, 1997, Pages 87-93

  Fisk, Bryan ^a   Anderson, Brett W ^a   Gravitt, Karen R ^a   O'Brian, Catherine A ^a   Kudelka, Andrzej P ^a   Murray, James L ^a   Wharton, J Taylor ^a   Ioannides, Constantin G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; HLA A2 ANTIGEN; PEPTIDE; TUMOR PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR RECOGNITION; OVARY TUMOR; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL LINE;

ANTIGENS, NEOPLASM; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; FEMALE; HLA-A2 ANTIGEN; HUMANS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; RECEPTOR, ERBB-2; TUMOR CELLS, CULTURED;

EID: 0031014415     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammense, H-G. Allele specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature (Lond.), 351: 290-296, 1991.
2. Tsomides, T. J., Aldovini, A., Johnson, R. P., Walker, B. D., Young, R. A., and Eisen, H. M. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by HIV type I. J. Exp. Med., 180: 1283-1293, 1994.
3. Wu, M. X., Tsomides, T. J., and Eisen, H. N. Tissue distribution of natural peptides derived from ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions. J. Immunol., 154: 4495-4502, 1995.
4. Udaka, K., Wiesmuller, K-H., Kienle, S., Jung, G., and Walden, P. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J. Exp. Med., 181: 2097-2108, 1995.
5. Huang, A. Y. C., Golumbek, P., Ahmadzadeh, M., Jaffe, E., Pardoll, D., and Levitsky, H. Role of bone-marrow derived cells in presenting MHC class I-restricted tumor antigens. Science (Washington DC), 264: 961-965, 1994.
6. Bevan, M. J. Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med., 182: 639-641, 1995.
7. Kovacsovics-Bankowski, M., and Rock, K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science (Washington DC), 267: 243-246, 1995.
8. Cox, A. L., Skipper, J., Chen, Y., Henderson, R. A., Darrow, T. L., Shabanowitz, J., Engelhard, V. H., Hunt, D. F., and Slingluff, C. L. Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science (Washington DC), 264: 716-719, 1994.
9. + CTL. J. Exp. Med., 181: 363-368, 1995.
10. Storkus, W. J., Zeh, III, H. J., Marurer, M. J., Salter, R. D., and Lotze, M. T. Identification of human melanoma peptides recognized by Class I restricted tumor infiltrating T lymphocytes. J. Immunol., 151: 3719-3727, 1993.
11. Ioannides, C. G., Fisk, B., Pollack, M., Frazier, M. L., Wharton, J. T., and Freedman, R. S. Cytotoxic T cell clones isolated from ovarian tumor infiltrating lymphocytes recognize common determinants on allogeneic tumors: implication for identification of TIL defined Ag on tumors. Scand. J. Immunol., 37: 413-424, 1993.
12. Yoshino, I., Goedegeboure, P. S., Peoples, G. E., Parikh, A. S., DiMain, J. M., Lyerly, H. K., Gazdar, A. F., and Eberlein, T. J. HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. Cancer Res., 54: 3387-3390, 1994.
13. Peoples, G. E., Goedegebuure, P. S., Smith, R., Linehan, D. C., Yoshino, I., and Eberlein, T. J. Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide. Proc. Natl. Acad. Sci. USA, 92: 432-436, 1995.
14. Zitvogel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., and Storkus, W. J. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med., 183: 87-97, 1996.
15. Celluzzi, C. M., Mayordomo, J. I., Storkus, W. J., Lotze, M. T., and Falo, J. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med., 183: 283-287, 1996.
16. Fisk, B., Blevins, T. L., Wharton, J. T., Ioannides, C. G. Identification of an immunodominant peptide of HER-2/neu proto-oncogene recognized by ovarian tumor specific CTL lines. J. Exp. Med., 181: 2709-2717, 1995.
17. Ioannides, C. G., Platsoucas, C. D., Rashed, S., Wharton, J. T., Edwards, C. L., and Freedman, R. S. Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites. Cancer Res., 51: 4257-4265, 1991.
18. Ioannides, C. G., Freedman, R. S., Rashed, S., Platsoucas, C. D., and Kim, Y-P. Cytotoxic T cell clones isolated from ovarian tumor infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells. J. Immunol., 146: 1700- 1707, 1991.
19. Slingluff, C. L., Jr., Cox, A. L., Henderson, R. A., Hunt, D. F., and Engelhard, V. H. Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes. J. Immunol., 150: 2955- 2963, 1993.
20. + T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA, 88: 11276-11280, 1991.
21. Sykulev, Y., Brunsmark, A., Tsomides, T. J., Kageyama, S., Jackson, M., Peterson, P. A., and Eisen, H. N. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogenic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA, 91: 11487-11491, 1994.
22. Fisk, B., Savary, C., Hudson, J. M. O'Brian, C. A., Murray, J. L., Wharton, J. T., and Ioannides, C. G. Changes in a HER-2 peptide up-regulating HLA-A2 expression affect both conformational epitopes and CTL recognition: implications for optimization of antigen presentation and tumor specific CTL induction. J. Immunother., 18: 197-209, 1996.
23. Ioannides, C. G., Fisk, B., Fan, D., Biddison, W. A., Wharton, J. T., and O'Brian, C. A. Cytotoxic T cells isolated from ovarian malignant ascites recognize a peptide derived from the HER-2/neu proto-oncogene. Cell. Immunol., 151: 225-234, 1993.
24. Yoshino, I., Peoples, G. E., Goedegebuure, P. S., Maziarz, R., and Eberlein, T. J. Association of HER-2/neu expression with sensitivity to tumor-specific CTL in human ovarian cancer. J. Immunol., 152: 2393-2400, 1994.
25. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell, 69: 989-998, 1992.
26. Griem, P., Wallny, H-J., Falk, K., Rotzschke, O., Arnold, B., Schonrich, G., Hammerling, G., and Rammensee, H-G. Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression. Cell, 65: 633-640, 1991.
27. Rivoltini, L., Barracchini, K. C., Viggiano, V., Kawakami, Y., Smith, A., Mixon, A., Restifo, N. P., Topalian, S. L., Simonis, T. B., Rosenberg, S. A., and Marincola, F. M. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res., 55: 3149-3157, 1995.
28. Peoples, G. E., Smith, R. C., Linnehan, D. C., Yoshino, I., Goedegebuure, P. S., and Eberlein, T. J. Shared T cell epitopes in epithelial tumors. Cell. Immunol., 164: 279-286, 1995.
29. Rotem-Yehudar, R., Groettrup, M., Soza, A., Kloetzel, P. M., and Ehrlich, R. LMP-associated proteolytic activities and TAP-dependent peptide transport for class I MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12. J. Exp. Med., 183: 499-514, 1996.
30. Boon, T., and van der Bruggen, P. Human tumor antigens recognized by T lymphocytes. J. Exp. Med., 183: 725-729, 1996.
31. Jerome, K. R., Domenech, N., and Finn, O. J. Tumor-specific CTL clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin cDNA. J. Immunol., 151: 1653-1662, 1993.
32. Ioannides, C. G., Ioannides, M. G., and O'Brian, C. A. T-cell recognition of oncogene products: a new strategy for immunotherapy. Mol. Carcinog., 6: 77-81, 1992.
33. Ioannides, C. G., Fisk, B., Melichar, B., Anderson, B., Stifani, S., Papayannopoulos, I., Murray, J. L., Kudelka, A., and Wharton, J. T. Ovarian and breast CTL can recognize peptides from the AES protein of the Notch complex. FASEB J., 10: A1437, 1996.