Pharmacokinetics of DA-125, a new anthracycline, after intravenous administration to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats

Drug Metabolism and Disposition

Volumn 25, Issue 1, 1997, Pages 66-74

  Yoon, Eun J ^b   Shim, Hyun J ^b   Lee, Jong J ^b   Lee, Sang D ^b   Kim, Won B ^b   Yang, Junnick ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; GALARUBICIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EXCRETION; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; URINARY EXCRETION;

AGE FACTORS; ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BILE; DESOXYCORTICOSTERONE; DOXORUBICIN; HYPERTENSION; LIVER; MALE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE;

EID: 0031013483     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. H. J. Shim, E. D. Lee, E. J. Yoon, S. D. Lee, W. B. Kim, J. Yang, and M. G. Lee: Simultaneous determination of a new anthracycline, DA-125, and its metabolites M1, M2, M3 and M4 in plasma and urine by high-performance liquid chromatography. J. Chromatogr. 656, 407-414 (1994).
2. H. J. Shim, E. D. Lee, E. J. Yoon, S. D. Lee, W. B. Kim, J. Yang, and M. G. Lee: Pharmacokinetics of FT-ADM after intravenous administration of DA-125, a prodrug of FT-ADM or FT-ADM to rats. A new adriamycin analog containing fluorine. Int. J. Pharm. 103, 147-154 (1994).
3. E. J. Yoon, E. D. Lee, W. H. Yoon, H. J. Shim, S. D. Lee, W. B. Kim, J. Yang, and M. G. Lee: Pharmacokinetics, tissue distribution and biliary excretion of FT-ADM after intravenous administration of DA-125, a prodrug of FT-ADM to dogs. A new adriamycin analog containing fluorine. Int. J. Pharm. 109, 181-187 (1994).
4. E. J. Yoon, W. I. Lee, H. J. Shim, S. D. Lee, W. B. Kim, J. Yang, and M. G. Lee: Comparison of pharmacokinetics of M1, M2, M3, and M4 after intravenous administration of DA-125 or ME2303 to mice and rats. New adriamycin analogs containing fluorine. Biopharm. Drug Dispos. 17, 373-420 (1996).
5. N. G. Baik, B. O. Ann, S. B. Lee, W. B. Kim, J. Yang, M. S. Kim, J. H. Kim, J. W. Park, H. H. Jung, and J. K. Roh: Less cardiotoxicity of DA-125, a novel anthracycline derivative, compared to doxorubicin (DXR). Proc. Am. Assoc. Cancer Res. 35, 410 (1994).
6. K. Okamoto and K. Aoki: Development of a strain of spontaneously hypertensive rats. Jpn. Circ. J. 27, 282-293 (1963).
7. H. A. T. Struyker-Boudier, J. F. M. Smits, J. C. S. Kleinjans, and H. Vanessen: Hemodynamic action of diuretic agents. Clin. Exp. Hypertens. A5, 209-223 (1983).
8. P. J. S. Chiu, S. Vemulapalli, and A. Barnett: Acute blood pressure and urinary responses to single dose combinations of captopril and diuretics in conscious spontaneously hypertensive rats. J. Pharm. Pharmacol. 37, 105-109 (1985).
9. R. J. Barrret, T. J. Buchenheimer, B. A. McGuirk, and S. T. Kau: Comparative cardiovascular effects of loop-acting, thiazide-type and potassium-sparing diuretics in spontaneously hypertensive rats. Methods Find. Exp. Clin. Pharmacol, 9, 67-78 (1987).
10. K. S. Han, S. H. Lee, M. G. Lee, and N. D. Kim: Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats. Biopharm. Drug Dispos. 14, 533-548 (1993).
11. S. H. Jang, M. G. Lee, and N. D. Kim: Pharmacokinetics and pharmacodynamics of furosemide after intravenous and oral administration to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats. Biopharm. Drug Dispos. 15, 185-206 (1994).
12. S. H. Jang, M. H. Lee, and M. G. Lee: Pharmacokinetics of acetaminophen after intravenous and oral administration to spontaneously hypertensive rats and normotensive Wistar rats. J. Pharm. Sci. 83, 810-814 (1994).
13. L. T. Beilin, D. N. Wade, A. J. Honour, and T. J. Cote: Vascular hyperreactivity with sodium loading and with deoxycorticosterone induced hypertension in the rat. Clin. Sci. 39, 793-810 (1970).
14. T. Sugai, Y. Nakagawa, K. Takeda, and S. Imai: Arterial pressure-urinary output relationship in DOCA-saline hypertensive rats. Am. J. Physiol. 245, R633-R636 (1983).
15. C. D. Sladek and M. L. Blair: Cholinergic stimulation of vasopressin release in spontaneously hypertensive rats. Hypertension 6, 855-860 (1984).
16. H. Loveless, E. Arena, R. L. Felsted, and N. R. Bachur: Comparative mammalian metabolism of adriamycin and daunorubicin. Cancer Res. 38, 593-598 (1978).
17. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall: Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
18. S. H. Kim, Y. M. Choi, and M. G. Lee: Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J. Pharmacokinet. Biopharm. 21, 1-17 (1993).
19. W. L. Chiou: Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J. Pharmacokinet. Biopharm. 6, 539-546 (1978).
20. W. L. Chiou: New calculation method for mean apparent drug volume of distribution and application to rationale dosage regimens. J. Pharm. Sci. 68, 1067-1069 (1979).
21. J. Caldwell, T. S. Emudianughe, and R. L. Smith: Species variation in the taurine conjugation of clofibric acid. Br. J. Pharmacol. 66, 421-422 (1979).